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Composition for PIORIDE

Pioglitazone(15 mg),Glimepiride(2 mg)

food interaction for PIORIDE

alcohol interaction for PIORIDE

pregnancy interaction for PIORIDE

lactation interaction for PIORIDE

There is no data available. Please consult doctor before consuming the drug.
Taking pioglitazone with alcohol may affect blood glucose levels in patients with diabetes.
Taking glimepiride with alcohol may affect blood glucose levels in patients with diabetes.
Pioride 15 mg/2 mg tablet may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Pioglitazone(15 mg)


It is used in combination with diet and exercise to lower blood glucose in adults with type 2 diabetes mellitus.

How it works

Pioglitazone belongs to class of thiazolidinedione. Pioglitazone decreases insulin resistance in the periphery and in the liver that helps the body make better use of insulin it produces and also decreases the glucose output from the liver.

Common side effects

Numbness, Abnormal liver function tests, Bladder cancer, Bone fracture, Insomnia, Nasal infection, Visual impairment, Weight gain
Glimepiride(2 mg)


Glimepiride is used to lower the blood sugar levels in type 2 diabetes mellitus when diet, physical exercise and weight reduction alone are not adequate.

How it works

Glimepiride belongs to a blood sugar lowering group of medicines called sulfonylurea. Glimepiride increases the amount of insulin released by the pancreas, and thereby decreases the blood sugar level.

Common side effects

Nausea, Diarrhoea, Bruise, Bleeding, Blood in stool, Dark colored urine, Dizziness, Sore throat, Stomach pain / epigastric pain, Yellow discoloration of skin, Yellow discoloration of eye, Weakness, Fever


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Expert advice for PIORIDE

Consult your doctor if you have any mental confusion, persistant abdominal pain, dark uine, yellowing of skin/eyes or easy bruising, Check your blood sugar regularly.
Consult your doctor: 
  • If you are allergic to pioglitazone or any of the other ingredients of this medicine. 
  • If you have heart failure or have had heart failure in the past.
  • If you have liver disease.
  • If you have had a complication of diabetes causing rapid weight loss, nausea or vomiting (diabetic ketoacidosis) or a special type of diabetic eye disease with swelling of the back of the eye(macular edema).
  • If you have ever had bladder cancer and blood in urine.
  • If you have cysts on your ovaries (polycystic ovary syndrome).

Frequently asked questions for PIORIDE


Q. Does pioglitazone cause hair loss?
No, pioglitazone does not cause hair loss. However, if you experience such side effects, consult your doctor.

Q. Does pioglitazone cause bladder cancer or any other cancer?
In clinical studies, more people who took pioglitazone for more than one year developed bladder cancer as compared to those who did not take pioglitazone. It is recommended to consult your doctor about the risk of taking this medication if you have had bladder cancer in the past or have a history of passing blood in urine. No other cancer type has been linked with use of pioglitazone.

Q. Does pioglitazone cause heart failure?
Pioglitazone can cause fluid retention, which may worsen or precipitate heart failure.

Q. Is pioglitazone safe?
Pioglitazone is safe if used at prescribed doses for the prescribed duration as advised by your doctor.


 Q. Is glimepiride a generic drug?
Yes, glimepiride is a generic drug sold under several pharmaceutical brand names (Amaryl, Zoryl, etc.).
Q. Can I take glimepiride with metformin or insulin?
Glimepiride may be given in combination with metformin and/or insulin depending on your medical condition and as prescribed by the doctor.
Q. Does glimepiride cause fluctuations in weight,diarrhea, hair loss, erectile dysfunction, swelling, constipation?
Glimepiride is reported to cause low blood sugar level,weight gain, and swelling, but is not reported to cause diarrhea, constipation, hair loss, or erectile dysfunction.
Q. Is glimepiride a fast acting sulfa drug?
Glimepiride is a medium- to long-acting sulfonylurea drug against type 2 diabetes mellitus (action lasts for 24 hours). Its maximum effect is seen after 2-3 hours of drug intake.
Q. Is glimepiride same as glipizide, glyburide, metformin, or insulin?
They are not same. Glimepiride, glipizide and glyburide belong to the same class of drugs called sulfonylureas. Metformin belong to class called biguanides.Glimepiride causes release of insulin but it is not insulin.It should only be used if no other alternative drug is available. Please follow your doctor's advice regarding its use.


Content on this page was last updated on 24 January, 2015, by Dr. Varun Gupta (MD Pharmacology)