Ostig 0.5mg Injection

Prescription Required
Store at room temperature (10-30°C)


Ostig 0.5mg Injection is a prescription medicine used in the treatment of myasthenia gravis (a disease causing muscle weakness and tiredness), paralytic ileus (paralysis of intestinal muscles), post-operative urinary retention and reversal of effect of skeletal muscle relaxants after surgery.

Ostig 0.5mg Injection works by reducing and improving muscle weakness. It is given as an injection under the supervision of a healthcare professional. Do not skip any doses and finish the full course of treatment and never stop this suddenly without talking to your doctor. However, before taking this medicine it is better to inform your doctor if you are suffering from any kidney disease, Parkinson's disease, asthma, or stomach disorders.

The most common side effects of this medicine are slow heart rate, nausea, and
vomiting. If you any other symptoms which you think are caused by the medicine, you should let your doctor know. They may be able to suggest ways to reduce or prevent the side effects.  Pregnant and breastfeeding women should consult the doctor before taking this medicine.

Uses of Ostig Injection

  • Treatment of Myasthenia gravis
  • Treatment of Paralytic ileus
  • Treatment of Post-operative urinary retention
  • Treatment of Reversal of effect of skeletal muscle relaxant after surgery

Side effects of Ostig Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Ostig

  • Nausea
  • Vomiting
  • Slow heart rate

How to use Ostig Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Ostig Injection works

Ostig 0.5mg Injection is a reversible cholinesterase inhibitor. It increases the level of acetylcholine, a chemical messenger in the brain, by suppressing acetylcholinesterase (enzyme). This acetylcholine further triggers muscle contracting receptors which helps in muscle contraction.

Safety Advice

Ostig 0.5mg Injection may cause excessive drowsiness with alcohol.
Ostig 0.5mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Ostig 0.5mg Injection is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
It is not known whether Ostig 0.5mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Ostig 0.5mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Ostig 0.5mg Injection may be needed. Please consult your doctor.
Regular monitoring of kidney function test and some blood tests may advised while you are taking this medicine.
Ostig 0.5mg Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Ostig 0.5mg Injection may not be needed in these patients. Please consult your doctor.

What if you forget to take Ostig Injection?

If you miss a dose of Ostig 0.5mg Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Ostig 0.5mg Injection
Tilstigmin 0.5mg Injection
Tablets India Limited
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Neotroy 0.5mg Injection
Troikaa Pharmaceuticals Ltd
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Myostigmin 0.5mg Injection 1ml
Neon Laboratories Ltd
28% costlier

Quick Tips

  • It is given into veins, muscles or under the skin by a healthcare professional.
  • Do not drink alcohol while taking this medicine as it may worsen the side effects.
  • Inform your doctor if you have an existing kidney problem, parkinson's disease, asthma, or stomach disorders.

Fact Box

Chemical Class
Phenoxy Compounds
Habit Forming
Therapeutic Class

Patient Concerns

Drooping of eyelids. What is the cause of it? What is the remedy?
Dr. Vishal Maniar
At ur age u need detailed eye checkup and neurologist referenceTo rule out myasthenia gravis, ocular palsy Bells palsy,diabetes,trauma
Right medicine for myasthenia gravis
Dr. Vikas Sharma
many ; cant advise online as they are strong medicine
Do you have any questions related to Ostig 0.5mg Injection ?


Q. Does Ostig 0.5mg Injection treat myasthenia gravis? How long do I need to take it?

Ostig 0.5mg Injection relieves the symptoms of myasthenia gravis but does not cure it. It does so by reducing and improving muscle weakness. The length of time for which you need to take Ostig 0.5mg Injection will depend on your condition. Do not stop taking Ostig 0.5mg Injection until and unless advised by your doctor, even if you start feeling better.

Q. How long does Ostig 0.5mg Injection take to start working?

Ostig 0.5mg Injection takes about 5 to 15 minutes to start working and remains effective for 2-4 hours.

Q. Is Ostig 0.5mg Injection a steroid?

No, Ostig 0.5mg Injection is not a steroid. It belongs to cholinesterase inhibitor group of medicines. Ostig 0.5mg Injection work by preventing the breakdown of a chemical called acetylcholine.

Q. Does it cause weight gain?

No, Ostig 0.5mg Injection does not cause weight gain. Your weight gain may be due to inactivity related to muscle weakness in myasthenia gravis.

Q. Is Ostig 0.5mg Injection safe to use?

Yes, Ostig 0.5mg Injection is safe if used in the dose and duration prescribed by the doctor.

Q. I felt better when I started taking Ostig 0.5mg Injection but I have noticed recently that I get tired easily and quickly. Will increasing the dose help me?

If your symptoms have started reappearing, then it could be due to increased severity of myasthenia gravis or excess dose of Ostig 0.5mg Injection. Both the conditions have similar effects, so it becomes very difficult to differentiate between the two. Do not increase the dose on your own and consult your doctor immediately.

Q. Can I take Ostig 0.5mg Injection for constipation?

No, Ostig 0.5mg Injection should not be taken for any type of constipation. However, its use is limited to cases of constipation caused by paralysis of intestine and strictly on prescription by the doctor.

Q. What should I do if I accidentally take more than the dose required?

You should seek immediate medical help in case of overdose of Ostig 0.5mg Injection.Excess of Ostig 0.5mg Injection may cause stomach pain, nausea, vomiting, diarrhea, blurred vision, difficulty in breathing, and excessive sweating, salivation, and weakness. It can even lead to paralysis.

Q. Does Ostig 0.5mg Injection have any abuse potential?

No, there is no evidence of Ostig 0.5mg Injection having any abuse potential.

Q. Who should not take Ostig 0.5mg Injection?

Ostig 0.5mg Injection should not be taken by patients who are allergic to it. Patients who are constipated or cannot urinate should avoid its use, unless advised by the doctor. This is because Ostig 0.5mg Injection is only used for certain types of urination problems and constipation (e.g. caused by paralysis of intestine).

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.


  1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 969.
  2. Drugs.com. Neostigmine Pregnancy and Breastfeeding Warnings. [Accessed 25 Mar. 2019] (online) Available from:External Link
  3. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Neostigmine. [Updated 2018 Oct 31]. [Accessed 20 Feb. 2020] (online) Available from:External Link
  4. Neostigmine. Gloucester Business Park, Gloucester: Hameln Pharmaceuticals Ltd.; 2001 [revised 12 Jan. 2018]. [Accessed 25 Mar. 2019] (online) Available from:External Link
  5. Neostigmine Methylsulfate Injection [FDA Label]. Chesterfield, MO: Éclat Pharmaceuticals; 2013. [Accessed 24 Sept. 2020]. (online) Available from:External Link
Country of Origin: India

Expires on or after: April, 2021

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