Overview
Uses and benefits
Side effects
How drug works
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
Patient concerns
FAQs

Author Details

Written By

Dr. Syeda Aafia

MBA, BDS

Reviewed By

Dr. Rajeev Sharma

MBA, MBBS

Last updated

01 Dec 2025 | 12:33 AM (IST)

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Not-Now Tablet Combipack

Prescription Required

Marketer

Signa Medisolutions Pvt Ltd

SALT COMPOSITION

Mifepristone (200mg) + Misoprostol (200mg)

Storage

Store below 25°C

Introduction of Not-Now Tablet Combipack

Not-Now Tablet Combipack is a combination of two medicines, which is used for medical abortion (terminating a pregnancy). This medicine blocks the action of progesterone, a female hormone required to maintain pregnancy and induce contractions in the uterus, which further helps in abortion.

Not-Now Tablet Combipack should be taken with food or as per your doctor's advice. You must start with a dose of Mifepristone. It should be taken orally, by swallowing the tablets whole with a glass of water. If you experience vomiting within 30 minutes of tablet intake, inform your doctor or take another tablet. The medicine may take 24- 48 hours to show its action and you might experience spotting or bleeding. After a period of 36-48 hours, you have to take Misoprostol tablet, either orally or vaginally. You are suggested to have proper rest after this dose intake as it may cause severe stomach pain or vaginal bleeding thus leading to abortion.

The most common side effects of this medicine include nausea, vomiting, diarrhea and stomach cramps. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Some side effects may mean you should inform your doctor immediately include heavy vaginal bleeding or abdominal pain.

Before taking this medicine, tell your doctor if you have ever had an ectopic pregnancy, or you are breastfeeding or using an intrauterine device. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. You must avoid strenuous activity like heavy exercise, running and driving while abortion as it can affect the bleeding. Your doctor may perform an ultrasound or pelvic examination to check for abortion completion.

Uses of Not-Now Tablet Combipack

Medical abortion

Benefits of Not-Now Tablet Combipack

In Medical abortion

Not-Now Tablet Combipack is used to cause an abortion during the early part of a pregnancy. It is used up to week 10 of pregnancy (up to 70 days after the first day of your last menstrual period). This medicine effectively blocks the natural female hormone, called progesterone, that is needed for your pregnancy to continue. Please use it only as advised by the doctor.

Side effects of Not-Now Tablet Combipack

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Not-Now

Nausea
Vomiting
Diarrhea
Stomach cramp
Uterine contractions
Menorrhagia (heavy menstrual bleeding)

How Not-Now Tablet Combipack works

Not-Now Tablet Combipack is a combination of two medicines: Mifepristone and Misoprostol, which causes abortion. Mifepristone blocks the effects of progesterone, a natural female hormone that is needed for the pregnancy to sustain. Without this hormone, the lining of the uterus (womb) breaks down as it does during a menstrual period and stops the growth of the pregnancy. Misoprostol increases contractions of the uterus to cause abortion.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Not-Now Tablet Combipack

Pregnancy

UNSAFE

Not-Now Tablet Combipack is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

UNSAFE

Not-Now Tablet Combipack is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Not-Now Tablet Combipack may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Not-Now Tablet Combipack in patients with kidney disease. Please consult your doctor.

Liver

SAFE IF PRESCRIBED

Not-Now Tablet Combipack is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

What if you forget to take Not-Now Tablet Combipack?

If you miss a dose of Not-Now Tablet Combipack, please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

No substitutes found for this medicine

Quick tips

Not-Now Tablet Combipack

Not-Now Tablet Combipack helps terminate a pregnancy.
Use caution while driving or doing anything that requires concentration as it can cause dizziness and sleepiness.
It does not affect fertility. Use contraception to avoid pregnancy.
For pregnancy termination:
- Take it no later than 63 days after the first day of your last menstrual period.
- Take Misoprostol 36 – 48 hours after taking Mifepristone.
- Rest for at least 3 hours after taking the Misoprostol.
- Take it only as prescribed by the doctor. Miscarriages, if incomplete, may result in serious medical complications leading to hospitalization, surgery and possible infertility.
- Vaginal bleeding lasting for approximately 12 days may occur after taking this medicine. Inform your doctor immediately if excessive bleeding occurs or if you suffer from severe abdominal pain.

Fact Box

Habit Forming

Therapeutic Class

GYNAECOLOGICAL

Patient concerns

hii , my period was late for about 10 days & I'm pregnant now ( checked) please consult me for protecting this I don't want to be pregnant , what i have to do

Dr. Asmita Kaundal

Obstetrics and Gynaecology

You are already pregnant now the only option is termination ( ABORTION ) . Kindly get an early pregnancy ultrasound done to localise the pregnancy . so that the medical abortion can be given

Sir, i m 56 days of pregnancy. I m married and i do not want baby now. Is medical abortion is legal in india. And can i do that at home by taking tablet. Is there heavy blooding after taking it.

Dr. Suman Rao

Obstetrics and Gynaecology

Yes it's legal. Consult a Gynae nearby. Don't take tab of your own

Dear doctor am 36 days pregnant and I want to terminate it.my suggest eugest200 capsule to take morning and night for 5 days.now already 3 days gone.still no result.does the tablet terminate preganancy?how many days did I take that?or which tablet is most powerful than this?

Dr. Asmita Kaundal

Obstetrics and Gynaecology

mam u ve already taken abortion pills now wait for a week else u need sugical abortion

my father is suffering from cancer in throat and in lever. Dr's are saying that he is in advance 4th stage. i want to know whether its curable or not Chemotherapy is going on with six cycles. 4 cycles completed. Chemo is going as. Earlier radiotherapy was done alst year after that pet ct was done and dr's said that the cancer cells are totally gone. but they again occur after a period of 6 months and that two in two locations mentioned above . so plz suggest accordingly considering all the facts.

Dr. Vijay Sharnangat

Medical Oncology and Hematology

Now not curable, continue palliative chemotherapy

sir, patient is my mother 13 years before she is taken successful surgical treatment for left breast cancer. till she lived healthy. but from last 1 year she suffered from too much of back ache when we show to Narayana health hospital bangalore they done PET CT scan , and Result they said is metastasis carcinoma, their is a sessions spread over ribs bones and L1 and other back bones they gave two time, half body per time Radiation therapy. now she relieved from pain. My question is is their full curable treatment for this disease please inform me

Dr. Vijay Sharnangat

Medical Oncology and Hematology

No , now not curable, only palliative therapy

FAQs

Not-Now Tablet Combipack

What is Not-Now Tablet Combipack and what is it used for?

Not-Now Tablet Combipack contains two medicines, Mifepristone, and Misoprostol. Not-Now Tablet Combipack is used for medical termination of pregnancy. It is only used to terminate a pregnancy which should not be more than 63 days old, counting from the first day of the last menstrual period.

How and in what dose should I take Not-Now Tablet Combipack?

Not-Now Tablet Combipack should only be taken as per the advice of the doctor. The course is started with Mifepristone. Misoprostol is advised after 36-48 hours of taking Mifepristone. However, Misoprostol should only be taken under the supervision of a gynecologist, at a clinic or hospital setting.

What should I expect after completing my course of Not-Now Tablet Combipack?

After taking Mifepristone, you may or may not experience vaginal bleeding. However, you may experience abdominal cramping, diarrhea, stomach pain, and nausea immediately after taking Misoprostol. You may also have vaginal bleeding within 4 hours of taking Misoprostol. You may also be asked to stay at the clinic or healthcare center for at least 3 hours after taking this medicine. After 14 days of taking Mifepristone (pill you took before Misoprostol), your gynecologist may run some blood tests or perform ultrasonography to confirm whether pregnancy has been terminated or not.

Can Not-Now Tablet Combipack affect my future chances of getting pregnant?

No, studies have shown that this medicine does not impair the fertility of the women. Your future chances of getting pregnant are as equal as those who have not taken this medicine.

What are the common side effects of taking Not-Now Tablet Combipack?

The common side effects of using Not-Now Tablet Combipack are abdominal pain, abdominal cramping, nausea, diarrhea, dizziness, uterine contractions, pelvic pain, and shivering. If you experience a very heavy vaginal bleeding or if any of these side effects bother you please consult with your gynecologist.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Shaw KA, Topp NJ, Shaw JG, et al. Mifepristone-misoprostol dosing interval and effect on induction abortion times: a systematic review. Obstet Gynecol. 2013 ;121(6):1335-1347. [Accessed 29 Nov. 2025]. Available from:
Esposito L, Kornfield MS, Rubin E, et al. Mifepristone-misoprostol combination treatment for early pregnancy loss after embryo transfer: a case series. F S Rep. 2023;4(1):93-97. [Accessed 29 Nov. 2025]. Available from: