Overview
Uses and benefits
Side effects
How to use
How drug works
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
Patient concerns
FAQs

Author Details

Written By

Dr. Anuj Saini

MMST, MBBS

Reviewed By

Dr. Rajeev Sharma

MBA, MBBS

Last updated

24 Nov 2025 | 12:22 PM (IST)

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Nope Cold Plus Tablet

Prescription Required

Marketer

John Walter Labs

SALT COMPOSITION

Aceclofenac (100mg) + Paracetamol (325mg) + Cetirizine (10mg) + Phenylephrine (5mg) + Caffeine (25mg)

View available alternative with same salt composition

Click here to view all substitutes

Product introduction

Nope Cold Plus Tablet is a medication that helps alleviate the common cold symptoms. It relieves a runny nose, watery eyes, sneezing, and nasal congestion or stuffiness. Furthermore, it inhibits the release of certain chemicals that cause inflammation, pain, and fever associated with colds.

Take Nope Cold Plus Tablet in the dose and duration as prescribed by the doctor. It may be taken with or without food. Take it regularly as long as it is required to get maximum benefits. Keep taking the medicine even if your symptoms disappear until you complete the dose. Do not stop taking the medicine suddenly unless the doctor tells you it is alright to stop.

Use of this medicine may cause nausea, vomiting, stomach pain, heartburn, and restlessness in some people. Let your doctor know if any of these side effects bother you. Before you take this medicine, let your doctor know about any other medicines you take. You should also tell your doctor if you have any problems with your heart, liver, or kidneys. Pregnant and breastfeeding women should consult their doctors first before taking this medicine.

Uses of Nope Cold Plus Tablet

Treatment of Common cold

Benefits of Nope Cold Plus Tablet

In Treatment of Common cold

Nope Cold Plus Tablet is a combination medicine that effectively relieves symptoms of the common cold, such as a blocked nose, runny nose, watery eyes, sneezing, and congestion or stuffiness. It helps loosen thick mucus, making it easier to cough out. It also shrinks the blood vessels and provides rapid relief that lasts for several hours. These actions make breathing easier.

Nope Cold Plus Tablet is safe and effective. It usually starts to work within a few minutes, and the effects can last up to several hours. Take it as prescribed by your doctor, and do not stop using it unless you are advised otherwise.

Side effects of Nope Cold Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Nope Cold Plus

Heartburn
Nausea
Vomiting
Stomach pain
Restlessness

How to use Nope Cold Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nope Cold Plus Tablet may be taken with or without food.

How Nope Cold Plus Tablet works

Nope Cold Plus Tablet combines five medicines: Aceclofenac, Paracetamol, Cetirizine, Phenylephrine, and Caffeine, which help treat common cold symptoms. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Paracetamol is an analgesic (pain reliever) and antipyretic (fever reducer). It works by blocking the release of certain chemical messengers that cause pain and fever. Cetirizine is an antihistamine medication. It treats allergy symptoms such as itching, swelling, and rashes by blocking the effects of a chemical messenger (histamine) in the body. Phenylephrine is a decongestant that narrows the small blood vessels, relieving congestion or stuffiness in the nose. Caffeine is a stimulant that decreases sleepiness caused by Cetirizine.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Nope Cold Plus Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Information regarding the use of Nope Cold Plus Tablet during pregnancy is not available. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Nope Cold Plus Tablet during breastfeeding is not available. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Nope Cold Plus Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Nope Cold Plus Tablet in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Nope Cold Plus Tablet in patients with liver disease.

What if you forget to take Nope Cold Plus Tablet?

If you miss a dose of Nope Cold Plus Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Nope Cold Plus Tablet

₹5.01/Tablet

Diecold Plus Tablet

Leeford Healthcare Ltd

₹3.78/tablet

25% cheaper

Criticold Advance Tablet

Leeford Healthcare Ltd

₹3.78/tablet

25% cheaper

Wincold Total Tablet

WINGS PHARMACEUTICALS PVT. LTD.

₹9.5/tablet

90% costlier

Cetisfy Total Tablet

Mestra Pharma Pvt Ltd

₹12.5/tablet

150% costlier

Aclopass Cold Tablet

Yuventis Lifesciences

₹7.43/tablet

48% costlier

Quick tips

Nope Cold Plus Tablet is used to relieve the common cold symptoms.
It can make you restless, so don't take it too close to bedtime.
Do not take it with any other medicine containing paracetamol (drugs for pain/fever or cough and cold) without first asking your doctor.
Stick to simple meals and avoid fatty or spicy foods to prevent nausea after taking this medicine.
To feel better during the common cold, drink plenty of fluids, especially warm water, soup, etc.

Fact Box

Habit Forming

Therapeutic Class

RESPIRATORY

Patient concerns

Risk grade 1 prostate enlargement, urine. Flow is normal but acidic , pus cells are 3 to 5 after medication. Urine color is dark yellow. Residual urine is 90 ml/cc in the bladder after urination , whether operation is necessary?

Dr. Sumit Sharma

Urology

Nope medical therapy will solve the problem

C/o AS is there any new information and treatment other than taking saaz Diagnosis as 6 months before

Vipul Aggarwal

Nope. Main stay of treatment is only being active amd doin regilar exercises

Common cold with bronchitis fever two days Fever with common cold & bronchitis

Dr. Gopal Bansilal Samdani

Paediatrics

There are many underlying causes of your symptoms. Different cause needs different treatment. Specific treatment cannot be given unless we establish exact underlying cause. Final and perfect diagnosis cannot be done without doing clinical examination of child. Please consult me or any other Paediatrician. will take detail history and will examine your child in detail. All information will be used to determine exact underlying cause of problem. Depending upon cause will prescribe you treatment. At time may ask you relevant investigations if necessary. Your child may need antibiotics and/or other prescription drugs.

Bouts , common cold. Some bouts .

Dr. Gopal Bansilal Samdani

Paediatrics

For cough, cold -- Prevent dehydration. Fluids may help thin secretions and soothe an irritated throat. Dry, hacking coughs respond to honey in hot water, tea, or lemon juice. Drink plenty of fluids to replace those lost from sweating and having a runny nose, get plenty of rest, eat healthily ? a low-fat, high-fibre diet is recommended, including plenty of fresh fruit and vegetables. OTC drugs, gargling with salt water and sucking on menthol sweets can help relieve a sore throat and blocked nose, are generally safe for older children and adults to take, but might not be suitable for babies, young children. Avoid applying Vicks VapoRub to babies and toddlers.You should never give children under 4 years of age over-the-counter cough and cold products without checking with your child's doctor. These medicines may harm young children.

What is Nope Cold Plus Tablet used for?

Nope Cold Plus Tablet is used to provide relief from cold and flu symptoms, including body pain, fever, runny nose, nasal congestion, sneezing, and headache. It combines pain relief with allergy and decongestant effects in one medicine.

Can Nope Cold Plus Tablet help during seasonal allergies with body aches?

Nope Cold Plus Tablet is particularly effective when you have allergic rhinitis combined with body pain or headache, as it addresses both allergic symptoms and pain simultaneously in one medicine.

Will Nope Cold Plus Tablet make me drowsy or increase alertness?

While cetirizine in Nope Cold Plus Tablet can cause mild drowsiness in some people, the caffeine in this medicine helps counteract drowsiness and keeps you more alert, making it suitable for daytime use with caution.

How quickly does Nope Cold Plus Tablet start working after taking it?

You may start experiencing relief from pain and congestion within 1 hour after taking Nope Cold Plus Tablet, with peak effects occurring within 1 to 2 hours for most symptoms.

Can I use Nope Cold Plus Tablet for a severe sinus headache with a blocked nose?

Nope Cold Plus Tablet is excellent for sinus‑related pain and congestion, as it unblocks nasal passages and reduces sinus pain and inflammation.

Should I avoid Nope Cold Plus Tablet if I have high blood pressure?

You should consult your doctor first because phenylephrine and caffeine present in Nope Cold Plus Tablet can raise blood pressure and may also affect cardiovascular function, requiring medical guidance for hypertensive patients.

Will Nope Cold Plus Tablet help with fever caused by viral infections?

Yes. The paracetamol component in Nope Cold Plus Tablet effectively reduces fever, while other medicines in Nope Cold Plus Tablet manage associated symptoms like body ache, congestion, and sneezing common in viral infections.

Can I drink coffee or tea while taking Nope Cold Plus Tablet?

Limit caffeine intake from other sources, as Nope Cold Plus Tablet already contains caffeine, and excessive caffeine can cause jitteriness, rapid heartbeat, anxiety, or sleep disturbances.

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