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Last updated on:
18 Apr 2019 | 01:29 PM (IST)
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Mext 50 mg Injection


Overview

Uses of Mext Injection

Mext 50 mg Injection is used in the treatment of cancer.

Mext Injection side effects

Common
  • Nausea
  • Vomiting
  • Loss of appetite
  • Dyspepsia
  • Abdominal pain
  • Increased liver enzymes
  • Stomatitis (Inflammation of the mouth)

How to use Mext Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Mext Injection works

Mext 50 mg Injection is an anti-cancer medication. It works by blocking an enzyme (dihydrofolate reductase) involved in DNA synthesis in cancer cells. This slows the growth of cancer cells and eventually kills them.

Mext Injection related warnings

Alcohol
CAUTION
It is unsafe to consume alcohol with Mext 50 mg Injection. Taking Methotrxate with alcohol increases the risk of liver damage.
Pregnancy
CAUTION
Mext 50 mg Injection is highly unsafe to use during pregnancy.
Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor.
Lactation
UNSAFE
Mext 50 mg Injection is unsafe to use during lactation. Data suggests that the drug may cause toxicity to the baby, or the mother is suffering from a condition in which breastfeeding is not advisable.
Driving
Mext 50 mg Injection may make you feel dizzy, drowsy or affect your vision. Do not drive until your vision is clear.
Kidney
CAUTION
Mext 50 mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Mext 50 mg Injection may be needed. Please consult your doctor.
Regular monitoring of kidney function test is advised while you are taking this medicine.
Liver
CAUTION
Mext 50 mg Injection should be used with caution in patients with liver disease. Dose adjustment of Mext 50 mg Injection may be needed. Please consult your doctor.
Use of Mext 50 mg Injection is not recommended in patients with severe liver disease.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Mext 50 mg Injection
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Expert Advice

  • Mext 50 mg Injection helps treat various types of cancer such as blood cancer, bone cancer, non-Hodgkin lymphoma (NHL), breast cancer, lung cancer, head and neck cancer, cervical cancer, ovarian cancer and testicular cancer.
  • Take it once a week, on the same day every week.
  • Drink plenty of liquids to stay hydrated while taking this  medication.
  • Always take folic acid as advised by your doctor. This will help lessen the side effects of this medicine.
  • It may take 6 to 8 weeks for Mext 50 mg Injection to work. Keep taking the medication as prescribed.
  • Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects.
  • It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.
  • Your doctor may get regular blood test done to monitor your kidney function, liver function and level of blood cells in your blood.

Interaction with Drugs

Taking Mext with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Nimsun, Abinim, Nimulis
SERIOUS
Brand(s): Densol
SERIOUS
Brand(s): Defmark, Zacdef, Ecodef
SERIOUS

Patient Concerns

Questions Related to Mext

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Patient is sufferng from Prostrate cancer and now he is suffering from Typhoid IGM.His hormone therapy(Inj Leuprolide 3.75 mg) is due for can we go ahead and ask doctor to induct hormone injection.
Dr. Vijay Sharnangat
Cancer Specialist
If patient has recovered, then only.
Submucouse fibrosis and unable to open mouth
Dr. Shubhra Chandan Pradhan
Ear Nose Throat Specialist
It is usually due to chronic tobacco chewing. If you are taking stop. Takes long time to improve. May become cancer later on. Can use hyalase and kenacort injection locally. Improve in few patients. It it very severe may need surgery
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FAQs

Q. Can Mext cause mouth ulcers?

Yes, in fact a sore mouth and mouth ulcers are sometimes side effects of Mext therapy. Taking folic acid along with this medicine may help in reducing the ulcers. Ask your doctor if the dose can be reduced as dose reduction may further help in reducing the ulcers.

Q. Why do I have to take folic acid with Mext?

Folic acid is required to make new cells in the body and Mext decreases the folic acid levels in the body. By taking folic acid some of the common side effects, like mouth ulcers, hair loss, nausea, heartburn, abdominal pain, fatigue, anemia and liver problems can be reduced.

Q. Why do I need to take regular blood tests while taking Mext?

Regular blood tests will help your doctor to check your response to Mext and monitor you for side effects. You will need to regularly check your liver function and your blood counts -white blood cells, red blood cells and platelets. Your doctor may also order additional tests depending on the results.

Q. Can Mext use make me more prone to infections?

Mext may decrease the activity of your immune system. As a result, you may develop serious infections. There have been rare reports of serious lung infections with Mext use. If you have an active infection, Mext should be used with extreme caution.

Q. Can Mext affect fertility?

Yes, it may affect fertility in both males and females. There maybe a decrease in sperm count in males and menstrual disturbances in females. These effects are reversible and disappear once the therapy is discontinued.

Q. What to do if I am planning to become pregnant and my husband is taking Mext?

You should avoid pregnancy if your husband is taking Mext. Also, avoid pregnancy for a minimum of 3 months after the therapy as it can lead to serious fetal abnormalities.

Related Products

Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 944-46.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 887-90.
  3. Drugs.com. Methotrexate Pregnancy and Breastfeeding Warnings. [Accessed 02 Apr. 2019] (online) Available from:External Link
Manufacturer/Marketer Address
Wallace Pharmaceuticals Pvt. Ltd., 3rd Floor, Dempo Trade Centre Bldg., Patto Plaza, EDC Complex, Panaji 403001, Goa, India.
A licensed pharmacy from your nearest location will deliver Mext 50mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your prescription and the availability of this medicine.
Best Price
₹86.25
MRP115  Get 25% OFF
Use coupon NEW25 to avail this offer on your first purchase. Valid only on orders above ₹800.
1 Injection in 1 vial
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