Mexate 25mg Injection

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Zydus Cadila

Composition for Mexate 25mg Injection

iconPrescription Required
Potentiallyunsafewith
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Alcohol
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Pregnancy
55
₹55.0/Injection
1 Injection in 1 vial
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Medicine Overview of Mexate Injection

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Uses of Mexate Injection

Mexate 25mg Injection is used in the treatment of blood cancer, bone cancer, non-Hodgkin lymphoma (NHL), breast cancer, lung cancer, head and neck cancer, cervical cancer, ovarian cancer and testicular cancer.
It is also used in rheumatoid arthritis, psoriasis (silvery scaly skin rash) and ectopic pregnancy at low doses.
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Side effects of Mexate Injection

Common

Nausea, Vomiting, Loss of appetite, Dyspepsia, Abdominal pain, Increased liver enzymes, Stomatitis (Inflammation of the mouth).

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How to use Mexate Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Mexate Injection works

Mexate 25mg injection is an anticancer and immunosuppressive medication. It works in cancer by slowing the growth of cancer cells by blocking building blocks that cancer cells need to grow. It also works in autoimmune disease by decreasing the activity of body's immune system and prevents the body from attacking itself.

In Depth Information on Mexate Injection

Expert advice for Mexate Injection

  • For autoimmune diseases, Mexate is taken by mouth, once a week (not every day) on the same day each week. It can take 2 to 3 weeks for Mexate to start working.
  • Notify your doctor immediately if you develop a sore throat or fever (infection), bruising or bleeding, nausea, abdominal pain or dark urine or difficulty breathing.
  • Your doctor may ask to get complete blood count (CBC), kidney function test (KFT) and liver function test (LFT) before starting treatment and thereafter also.
  • Mexate may harm your unborn babies or cause miscarriages. You and your partner should avoid conception (becoming pregnant or fathering children) for at least three months after your treatment with Mexate has stopped.
  • Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
  • Inform your doctor if you have ever been diagnosed with kidney or liver problems.
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Warnings
Special precautions for Mexate 25mg Injection
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Alcohol
CAUTION
Taking Methotrxate with alcohol increases the risk of liver damage.
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Pregnancy
CAUTION
Mexate 25mg Injection is highly unsafe to use during pregnancy.

Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor.
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Lactation
UNSAFE
Mexate 25mg Injection is usafe to use during lactation. Dat
a suggests that the drug may cause toxicity to the baby, or the mother is suffering from a condition in which breast feeding is not advisable.
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Driving
Mexate 25mg Injection may make you feel dizzy, drowsy or aff
ect your vision. Do not drive until your vision is clear.
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Kidney
CAUTION
Mexate 25mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Mexate 25mg Injection may be needed. Please consult your doctor.

Regular monitoring of kidney function test is advised while you are taking this medicine.
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Liver
CAUTION
Mexate 25mg Injection should be used with caution in patients with liver disease. Dose adjustment of Mexate 25mg Injection may be needed. Please consult your doctor.

Use of Mexate 25mg Injection is not recommended in patients with severe liver disease.
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Severely interacts with other drugs like
Decamycin 4mg Injection, Walacort 0.5mg Tablet, Pericort 4mg Tablet, Depo Medrol 40mg Injection

Patient Concerns

Frequently asked questions for Mexate 25mg Injection

Frequently asked questions for Methotrexate

Mexate is not a steroid or non-steroidal anti-inflammatory drugs (NSAIDs). It is a chemotherapy drug used in the treatment of different types of cancer and it is also a disease-modifying antirheumatic drugs (DMARD) used in the treatment of severe rheumatoid arthritis
Mexate belongs to a class of drugs known as antimetabolites used to treat severe, uncontrolled psoriasis. Mexate is safe if used at prescribed doses for the prescribed duration as advised by your doctor
Yes. Mexate's chemotherapeutic effects are cell-cycle specific as it inhibits the DNA synthetic phase, i.e. it inhibits the synthesis of DNA (genetic material) of the cells. Hence in cancer treatment, it kills the cancerous cells and reduces the tumor size
Mexate is safe if used at prescribed doses for the prescribed duration as advised by your doctor
No. Mexate is not a narcotic drug/ biologic drug
Q. Can I take methotrexate with antibiotics (e.g. amoxicillin, Bactrim)/ ibuprofen/ prednisone/ naproxen/ aspirin/ paracetamol?
No. Methotrexate interacts with antibiotics (e.g. amoxicillin, Bactrim), ibuprofen, prednisone, naproxen, aspirin, paracetamol. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required
Always consult your doctor regarding its use if you have any symptoms of infection such as cold
Mexate belongs to a class of drugs known as antimetabolites. It is used for the treatment of wide range of cancer and tumors. However it may increase the risk of secondary malignancies such as melanoma and other cancers
Mexate may cause side effects such as fatigue, diarrhea, acne, mood swings, nausea, and infertility. But it has no known effect on weight gain/ weight loss
Mexate belongs to a class of drugs known as antimetabolites. Mexate is used for the treatment of wide range of cancers or tumors including acute leukemias (a type of blood cancer), non-Hodgkin's lymphoma (a type of cancer of immune system cells that help the body fight infections), soft-tissue (fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues of the body) and osteogenic sarcomas (bone cancer), and solid tumors (cancers) of the breast, lung, head and neck, bladder, cervical, ovarian, choriocarcinoma and testicular carcinoma. It is also used to treat severe, uncontrolled psoriasis (skin condition where scaly patches were formed due to fast growing cells) and rheumatoid arthritis (inflammatory disorder that typically affects the small joints in hands and feet) only if these have not responded to other frontline treatments.
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