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17 May 2019 | 05:28 PM (IST)
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Metofix-XL 500 Tablet


Overview

Introduction of Metofix Tablet PR

Metofix-XL 500 Tablet is a medicine used in the treatment of type 2 diabetes mellitus. It helps to lower the high blood sugar levels and prevents long-term complications. This drug should be used along with a proper diet and regular exercise for best results. It should be taken with food to avoid the side effects of nausea and upset stomach.

Uses of Metofix Tablet PR

Metofix Tablet PR side effects

Common
  • Nausea
  • Vomiting
  • Taste change
  • Diarrhea
  • Abdominal pain
  • Loss of appetite
Severe
  • Lactic acidosis

How to use Metofix Tablet PR

Use it as advised by your doctor or check the label for directions before use. Metofix-XL 500 Tablet is to be taken with food.

How Metofix Tablet PR works

Metformin is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying sugar (glucose) absorption from intestines and increasing the body's sensitivity to insulin.

Metofix Tablet PR related warnings

Alcohol
CAUTION
It is unsafe to consume alcohol with Metofix-XL 500 Tablet. Taking metformin with alcohol can cause lactic acidosis and you may experience malaise, respiratory distress, slow or irregular heartbeat, sleepiness, stomach upset, or other unusual symptoms.
Pregnancy
PROBABLY SAFE
Metofix-XL 500 Tablet is probably safe to use during pregnancy.
Animal studies have shown low or no adverse effect on the fetus, however, there are limited human studies. Please consult your doctor.
Lactation
Metofix-XL 500 Tablet is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.
Driving
Your ability to drive may be affected if your blood sugar is low or high. If this happens, do not drive.
Kidney
CAUTION
Metofix-XL 500 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Metofix-XL 500 Tablet may be needed. Please consult your doctor.
Use of Metofix-XL 500 Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Liver
CAUTION
Metofix-XL 500 Tablet should be used with caution in patients with liver disease. Dose adjustment of Metofix-XL 500 Tablet may be needed. Please consult your doctor.
Metofix-XL 500 Tablet is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.

What if you miss a dose of Metofix Tablet PR?

If you miss a dose of Metofix-XL 500 Tablet, skip it and continue with your normal schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Metofix-XL 500 Tablet
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Expert Advice

  • Chances of weight gain and low blood sugar are lesser as compared to other diabetes medicines. 
  • Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.
  • Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, and stomach pain as Metofix-XL 500 Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
  • Vitamin B12 deficiency and symptoms of anemia like fatigue, pale skin, shortness of breath or headache may occur. Notify your doctor if you experience any of these as you may require supplements.
  • Your doctor will monitor your blood sugar levels and kidney functions regularly while taking this medication.

Interaction with Drugs

Taking Metofix with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Kopram, Ecit, Escnx
SERIOUS
Brand(s): Digeplex T
SERIOUS
Brand(s): Psycool, Proparise
SERIOUS
Brand(s): Densol
SERIOUS
Brand(s): Zencort-M, Welone
SERIOUS
Brand(s): Nudiglue-C
SERIOUS
Brand(s): Defmark, Zacdef, Ecodef
SERIOUS
Brand(s): Leparox, Prx
SERIOUS
Brand(s): Acigo, Rin, Ranis
SERIOUS

Patient Concerns

Questions Related to Metofix

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Ayurvedic treatment for type 2 diabetesI am already on metformin 500 mg
Dr. Aanchal Maheshwari
Ayurveda
Depend upon , the value of blood sugar
Type 2 diabetes taking glyciphage 500 one time daily and high bp avg 140/100 taking olmat 20 once
Dr. Deepak Kumar Soni
Skin Specialist
https://www.1mg.com/otc/bgr-34-tablet-otc3226311-1 Tablet after lunch & dinner, Take at least 1-2 months.take this medicine along with your treatment
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Do you have any questions related to Metofix-XL 500 Tablet?

User Feedback


FAQs

Q. Does Metofix clear acne?

Metofix is not indicated specifically to clear acne. However, in women with polycystic ovarian syndrome (PCOS), it helps clear acne along with other problems like facial hair, abdominal obesity, and irregular menstruation.

Q. Can I take Metofix forever?

Metofix is generally a safe and well-tolerated drug even on long-term use. However, it should be used for the duration prescribed by your doctor.

Q. Does Metofix cause weight gain?

No, weight gain has not been reported with Metofix. Rather, it helps in decreasing weight especially in abdominal fat patients of type 2 diabetes mellitus. In women with polycystic ovarian syndrome (PCOS), it helps in losing weight along with relieving other problems like facial hair, acne, and irregular menstruation.

Q. Can the use of Metofix cause vitamin B12 deficiency?

Yes, long-term use of Metofix can cause vitamin B12 deficiency. long-term use interferes with the absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can have tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in making balance (ataxia). To avoid these problems, doctors usually suggest an intake of vitamin B12 from outside at least once every year.

Q. Is Metofix helpful in patients with polycystic ovarian syndrome (PCOS)?

Yes. Metofix is used off-label in the treatment of PCOS. It may be used along with other medicines to induce ovulation and regularize menstrual cycles.

Q. How does Metofix help in weight loss?

Metofix helps in weight loss by decreasing the hunger (appetite), and hence, the food intake. It makes the insulin already available in your body to work more effectively. This leads to a decrease in glucose production, increase the glucose use and decrease the fat deposits which further helps to lower the body weight.

Q. Does Metofix cause bloating?

Yes, the use of Metofix can cause bloating. To minimize this side effect, it is advised to take it after your meals.

Q. Is Metofix useful in the treatment of infertility?

Metofix is prescribed to improve the insulin resistance in the body. Proper insulin resistance regulates ovulation, maintains proper androgen levels in the body, and improves menstrual regularity. This increases the pregnancy rates and outcomes and indirectly treats the infertility associated with polycystic ovary syndrome (PCOS).

Q. Is Metofix useful in the treatment of prediabetes?

Metofix is seen to be useful in the management of prediabetes, a condition with blood glucose levels higher than normal but not high enough to label you as diabetic. Metofix makes the insulin already available in your body to work more effectively, decreases glucose production by liver and increases use of glucose by the muscles and lowers body weight. However, lifestyle modifications like a change in diet and exercise should be tried first as they are seen to be more effective than Metofix.

Q. Does Metofix cause blurry vision?

Metofix is not known to cause blurred vision. Change in vision in a patient with diabetes could be due to multiple reasons. Please consult your doctor if blurred vision occurs.

Q. Does Metofix use leads to anemia?

Metofix may decrease the levels of vitamin B12 on long term use which may rarely cause a type of anemia in which blood cells are larger than normal (megaloblastic anemia). You may need to take foods rich in vitamin B12 like eggs, dairy products, and meat or a supplement from outside.

Q. How beneficial is it to take Metofix with linagliptin?

Both Metofix and linagliptin are anti-diabetic drugs and can be used together. Their fixed dose combinations are also available and commonly advised once Metofix is unable to control blood sugar levels even after giving the maximum tolerated dose. As they work by different mechanisms, they help in better control of blood sugar levels compared to either drug taken alone.

Related Products

Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Powers AC, D’Alessio D. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1258-60.
  2. Nolte MS. Pancreatic hormones and antidiabetic drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 741-42.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 873-75.
  4. Metformin hydrochloride. Princeton, New Jersey: Bristol-Myers Squibb Company. [Accessed 12 Mar. 2019] (online) Available from:External Link
  5. Metformin hydrochloride oral solution. Gloversville, New York: Ranbaxy Pharmaceuticals Inc.; 2003. [Accessed 12 Mar. 2019] (online) Available from:External Link
  6. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-98. [Accessed 12 Mar. 2019] (online) Available from:External Link
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