Metfil 500 mg Tablet


Overview

Uses of Metfil Tablet
Metfil 500 mg Tablet is used in the treatment of type 2 diabetes. It is used in addition to diet and exercise to improve blood sugar control in adults with type 2 diabetes.
Metfil Tablet side effects
Common
  • Nausea
  • Vomiting
  • Taste change
  • Diarrhoea
  • Abdominal pain
  • Loss of appetite
How to use Metfil Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Metfil 500 mg Tablet is to be taken with food.
How Metfil Tablet works
Metformin is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying sugar (glucose) absorption from intestines and increasing the body's sensitivity to insulin.
Metfil Tablet related warnings
Alcohol
CAUTION
Taking metformin with alcohol can cause lactic acidosis and you may experience malaise, respiratory distress, slow or irregular heartbeat, sleepiness, stomach upset, or other unusual symptoms.
Pregnancy
PROBABLY SAFE
Metfil 500 mg Tablet is probably safe to use during pregnancy.
Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.
Lactation
Metfil 500 mg Tablet is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.
Driving
Your ability to drive may be affected if your blood sugar is low or high. If this happens, do not drive.
Kidney
CAUTION
Metfil 500 mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Metfil 500 mg Tablet may be needed. Please consult your doctor.
Use of Metfil 500 mg Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Liver
CAUTION
Metfil 500 mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Metfil 500 mg Tablet may be needed. Please consult your doctor.
Metfil 500 mg Tablet is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.
What if you miss a dose of Metfil Tablet?
If you miss a dose of Metfil 500 mg Tablet, skip it and continue with your normal schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Metfil 500 mg Tablet
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Expert Advice

  • You have been prescribed Metfil 500 mg Tablet to control the blood sugar level and reduce the risk of diabetic complications, such as heart  attacks.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines (if prescribed) along with Metfil 500 mg Tablet.
  • It does not cause weight gain and rarely causes low blood sugar unlike other diabetes medicines.
  • An upset stomach with nausea and diarrhoea may occur in the first two weeks; take it with food to avoid an upset stomach.
  • Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.
  • Tell your doctor immediately if you experience any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain as Metfil 500 mg Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
  • Vitamin B12 deficiency and symptoms of anemia like fatigue, pale skin, shortness of breath or headache may occur. Notify your doctor if you experience any of these as you may require supplements.
  • Your doctor will monitor your blood sugar levels and kidney functions regularly while taking this medication.

Interaction with Drugs

Taking Metfil with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Lafter
SERIOUS
Brand(s): Kopram, Ecit, Escnx
SERIOUS
Brand(s): Stacort
SERIOUS
Brand(s): Ducort, Defmark, Zacdef
SERIOUS
Brand(s): Acigo, Ranis
SERIOUS
Brand(s): Nudiglue-C
SERIOUS
Brand(s): Psycool, Proparise
SERIOUS
Brand(s): Leparox, Prx
SERIOUS
Brand(s): Zencort-M, Welone, Rigapred
SERIOUS
Brand(s): Digeplex T
SERIOUS

Patient Concerns

Questions Related to Metfil

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High cholesterol and lipid. Also type 2 diabetes under control. Vegetarian. Pls advise on dite
Dr. Waseem Mirza
Sexologist
Per day calorie intake should be between 1,500-1,800 calories with a proportion of 60:20:20 between carbohydrates, fats and proteins, respectively, take Healthy fats from raw nuts, olive oil, fish oils, flax seeds etc, fresh Fruits and vegetables,whole grains, legumes and other high-fibre diet, avoid refined carbohydrate diet,if u eat non veg u can take fish, poultry egg white, pulses whereas avoid red meat, avoid saturated fats like ghee, butter, avoid sweet foods, take small but frequent meals, supplements containing omega 3 fatty acids like Multivite fm omega capsule Quit smoking, avoid too much alcohol intake, find ways to reduce stress like meditation, yoga, etc. Moderate exercise daily like a brisk walk for 1 km. hope it helps
I was diagnosed with type 2 diabetes in January and I m taking medicine. Now it's under control. Can you suggest me a meal plan that I can go for to control my weight and diabetes. Thank you
Dr. Shikha Mishra
Dietician
eat 6-7 meals per day, which consist fruits, nuts, buttermilk,egg, homecooked food. Drink 3-4 litters of water.Be active whole day for personalized diet chart write to me on shikhamishra.nutrition@gmail.com do minimum 45 min exercise everyday like yoga, cardio or weights
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User Feedback


FAQs

Q. Is Metfil helpful in patients with polycystic ovarian syndrome (PCOS)?
Yes. Metfil is helpful in patients with PCOS. It may be used along with other medicines to induce ovulation and regularize menstrual cycles. It also delays the development of type 2 diabetes if you already have prediabetes and aids in weight loss if you follow a diet and exercise program.
Q. How does Metfil help in weight loss?
Metfil helps in weight loss by decreasing hunger (appetite) and hence food intake. It makes the insulin already available in your body to work more effectively. This leads to decrease glucose production, increase glucose use and decreased fat deposits which further helps to lower body weight. However, it is not yet approved for weight loss, this is an off-label use.
Q. Is Metfil useful in the treatment of infertility?
Metfil is commonly used off-label for the treatment of infertility associated with polycystic ovary syndrome (PCOS). It regulates ovulation and androgen levels in the body and improves menstrual regularity and pregnancy rates and outcomes. This beneficial effect is thought to be due to improvement in insulin resistance by Metfil.
Q. Does Metfil cause low blood sugar levels (hypoglycemia)?
Metfil can lower blood sugar level (hypoglycemia). It happens more often if you delay or miss your food, do more than your routine exercise, drink alcohol or take other antidiabetic medicine along with. So, regular monitoring of blood sugar level is important and be cautious of symptoms of hypoglycemia and always keep glucose tablets, honey or fruit juice with you.
Q. Can I take Metfil forever?
Metfil is generally a safe and well-tolerated drug even on long-term use. However, its long-term use can cause vitamin B12 deficiency leading to anemia and peripheral neuropathy (nerve damage). so, it should be taken only at prescribed doses for the duration as advised by the doctor.
Q. Is Metfil a sulfonylurea?
No, Metfil is not a sulfonylurea. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise.
Q. Is Metfil a steroid?
No, Metfil is not a steroid. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modifications in diet and exercise.
Q. Does Metfil cause bloating?
Metfil commonly causes stomach upset like bloating (heavy and uncomfortable feeling in the stomach), nausea, vomiting, and diarrhea. To avoid these side effects, it is advised to be taken after meals, preferably started at a low dose and then increased slowly over weeks, or by using slow-release tablets.
Q. Is Metfil good for fatty liver?
Metfil is seen to be beneficial in the treatment of non-alcoholic fatty liver disease (NAFLD). One of the underlying cause of NAFLD is insulin resistance. Metfil improves insulin resistance and liver enzymes in these patients. It is not seen to benefit patients of alcoholic fatty liver disease and is usually avoided in patients with liver cirrhosis as they are at an increased risk of lactic acidosis.
Q. What is the benefit of combining Metfil with coenzyme q10?
Coenzyme Q10 is an antioxidant that helps in energy production and is found in heart, liver, kidney, and pancreas (which produces insulin). It can repair the damage caused to these organs by free radicals. Low levels of CoQ10 are seen in patients with diabetes. So, some researchers suggest it be given from outside. It can be taken with Metfil as no drug-drug interactions or harmful effects have been seen between the two.
Q. Does Metfil help in improving your menstrual cycle (periods)?
Yes, Metfil does improve menstrual cycle (periods) regularity in women with polycystic ovarian syndrome (PCOS). It is associated with insulin resistance, decreased ovulation, and high androgen levels which cause menstrual irregularities like delayed periods and scanty bleeding. Metfil helps in regularizing menstrual cycles by improving insulin sensitivity, ovulation rate, and decreasing androgen levels.
Q. Can I take Metfil with atorvastatin?
Yes, Metfil can be taken with atorvastatin. There are no reported harmful effects when they are used together. Rather some studies suggest beneficial effects in diabetics as they may prevent a very high increase in blood glucose after food, decrease some inflammation markers and protect the patients from liver injury.
Q. Can I take Metfil with phentermine?
Metfil can be taken with phentermine. These are sometimes given together in obese patients who are also diabetic and are taking Metfil along with exercise and diet modification. Phentermine decreases food intake by its action in the brain. However, phentermine can decrease the effect of Metfil leading to very high blood glucose levels. So, a dose adjustment of Metfil may be needed.
Q. Can I take Metfil with levothyroxine?
Metfil can be taken with levothyroxine but the dose of Metfil may need to be adjusted. Levothyroxine can decrease the effect of Metfil leading to very high blood glucose levels. These are used together in patients with coexisting thyroid disease and diabetes mellitus or polycystic ovarian syndrome (PCOS).
Q. Can I take Metfil with prednisolone?
Metfil can be taken with prednisolone but the dose of Metfil may need to be adjusted. Prednisolone can decrease the effect of Metfil leading to very high blood glucose levels. Continuous use of steroids like prednisolone can also cause diabetes known as glucocorticoid-induced diabetes and use of Metfil is recommended in these patients.
Q. Can I take Metfil with metoprolol?
Metfil can be taken with metoprolol. There are no reported drug interactions or harmful effects in humans when they are used together. However, some animal studies suggest that metoprolol can decrease the blood levels of Metfil and on long-term use can increase lactic acid and uric acid levels.
Q. Does Metfil clear acne?
Metfil is not indicated for clearing acne due to just any condition. It only helps in clearing acne in women with polycystic ovarian syndrome (PCOS) along with other problems like facial hair, abdominal obesity, and irregular menstruation.
Q. Does Metfil cause hair loss?
No, hair loss has not been reported with Metfil. It only helps in clearing facial hair (hirsutism) in women with polycystic ovarian syndrome (PCOS) along with other problems like acne, abdominal obesity, and irregular menstruation.
Q. Does Metfil cause weight gain?
No, weight gain has not been reported with Metfil. Rather it helps in decreasing weight especially abdominal fat patients of type 2 diabetes mellitus and in women with polycystic ovarian syndrome (PCOS) along with other problems like facial hair, acne, and irregular menstruation.
Q. Does Metfil cause constipation?
Metfil is not known to cause constipation. Some common side effects associated with the use of Metfil includes nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite.
Q. Is Metfil safe?
Metfil is a safe and well-tolerated drug even on long-term use when taken strictly as advised by the doctor. However, there are some very common side effects like nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite you may experience even at therapeutic doses.
Q. Does Metfil increase blood pressure?
Metfil is not known to increase blood pressure. Some common side effects associated with the use of Metfil includes nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite.
Q. Is Metfil an insulin?
No, Metfil is not an insulin. Metfil is an oral drug used in type 2 diabetes mellitus and lowers blood glucose levels by decreasing its production and increasing absorption and making the already available insulin in your body to work better. Insulin is a normally produced hormone in the body, used in the injectable form in the treatment of both type 1 and 2 diabetes mellitus and it works by absorbing and storing glucose from the blood.
Q. Is Metfil a banned drug?
No, Metfil is not a banned drug. It is a prescription medicine and is available when prescribed by registered medical practitioner.
Q. Is Metfil a birth control pill?
No, Metfil is not a birth control pill. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise.
Q. Is Metfil a statin?
No, Metfil is not a statin. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise.
Q. Can I take Metfil with saxagliptin?
Both Metfil and saxagliptin are anti diabetic drugs and can be used together. Their fixed dose combinations are also available and commonly advised once Metfil is unable to control blood sugar levels even after giving the maximum tolerated dose. As they work by different mechanisms, they help in better control of blood sugar levels compared to either drug taken alone.
Q. Does Metfil cause blurry vision?
Metfil is not known to cause blurred vision. Change in vision in a patient with diabetes could be due to multiple reasons. It could be a temporary problem either due to high blood sugar levels which cause your lens inside your eye to swell and change your vision. If the blurred vision continues for a long time, consult a doctor.
Q. What is lactic acidosis and how is it related to Metfil use?
Lactic acidosis is a rare, but serious complication associated with the use of Metfil. Patient has high blood lactic acid levels and may present with tiredness, weakness, stomach pain, loose stools, severe muscle pain, muscle cramps and difficulty in breathing. It is especially seen in old age patients, those with kidney, liver or heart disease, or who take large amounts of alcohol. If you have these symptoms, stop taking Metfil and consult your doctor.
Q. Is Metfil use associated with liver pain?
Metfil is not known to cause any liver pain or damage. Rather, it is seen to be useful in patients with non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C. However, it is usually avoided in patients with liver cirrhosis as they are at an increased risk of lactic acidosis which is a serious complication associated with the use of Metfil.
Q. Does Metfil make you feel high?
No, Metfil does not elevate the mood or make you feel high. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise. Rare side effects of Metfil include anxiety and depression.
Q. Can Metfil cause back pain?
Usually, Metfil is not associated with back pain. However, it can be a presentation of stomach upset, a common side effect caused by Metfil which includes bloating (heavy and uncomfortable feeling in the stomach), nausea, vomiting, and diarrhea, or it could be a symptom of lactic acidosis, a rare and a serious complication of Metfil.
Q. Can long-term use of Metfil cause vitamin b12 deficiency?
Yes, Metfil causes vitamin B12 deficiency on long-term use as it interferes with absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can have tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in making balance (ataxia). To avoid these problems, some researchers suggest an intake of vitamin B12 from outside at least once every year.
Q. Is Metfil useful in the management of metabolic syndrome?
Yes, Metfil is seen to be useful in the management of metabolic syndrome, a collection of risk factors that include high blood pressure, high blood sugar levels, abnormal blood cholesterol levels and excess fat around the waist. Metfil is an insulin sensitizer and it improves the action of insulin and normalises blood sugar levels and reduces body weight.
Q. How beneficial is it to take Metfil with glimepiride?
Both Metfil and glimepiride are anti diabetic drugs and can be used together. They work by different mechanisms and can control the blood sugar levels in a much better way when used together as compared to either drug taken alone. However, glimepiride can cause very low blood glucose levels, so a regular monitoring of blood glucose is very important.
Q. Is it safe to take Metfil with cetirizine?
Yes, Metfil can be taken with cetirizine. There are no reported drug interactions or harmful effects when they are used together.
Q. Can I take Metfil and ranitidine together?
Metfil can be taken with ranitidine. However, if you are taking them together, you need to monitor blood glucose levels regularly as ranitidine can decrease the removal of Metfil from the body and increase its blood levels. This can cause very low blood sugar levels and other side effects as well and the dose of Metfil may need adjustment.
Q. How beneficial is it to take Metfil with linagliptin?
Both Metfil and linagliptin are anti-diabetic drugs and can be used together. Their fixed dose combinations are also available and commonly advised once Metfil is unable to control blood sugar levels even after giving the maximum tolerated dose. As they work by different mechanisms, they help in better control of blood sugar levels compared to either drug taken alone.
Q. Does Metfil inhibit hepatitis B virus protein?
Yes, some research studies have shown that Metfil can decrease the multiplication and growth of hepatitis B virus when given along with other antiviral drugs. However, this is indication is still under research and not yet approved.
Q. Can I take Metfil before or after a chest x-ray? Does its use lead to chest x-ray abnormality?
Metfil should be temporarily discontinued before chest or any X-ray that requires injection of a contrast medium or dye. These dyes can decrease kidney function and Metfil along with these dyes can cause a serious side effect like lactic acidosis. So you may need to stop taking Metfil. However, do not stop taking any medicine without talking to your doctor.
Q. Does Metfil make you sleepy?
Metfil can cause sleepiness which could be an early symptom of lactic acidosis along with tiredness, weakness, stomach pain, loose stools, severe muscle pain, muscle cramps and difficulty in breathing. It is a serious condition caused by Metfil seen in old age patients, those with kidney, liver or heart disease, or those who take large amounts of alcohol. If you have these symptoms, stop taking Metfil and consult your doctor.
Q. Does the use of Metfil cause joint pain?
Use of Metfil is not associated with joint pain. However, diabetes itself decreases blood circulation to the joints and even damages them leading to joint pain. Use of anti-diabetic drugs like sitagliptin or saxagliptin is also associated with joint pain. Early symptoms of lactic acidosis like muscle pain and cramps with weakness and tiredness can be mistaken for joint pain.
Q. Can Metfil help in reducing weight gain caused by antipsychotics?
Metfil may be of help in the treatment and prevention of weight gain caused by antipsychotics along with lifestyle modifications like a change in diet and regular exercise. Weight gain is an important reason for discontinuation of these medicines. Metfil improves insulin sensitivity and prevents weight gain, both of these factors are affected by the use of antipsychotics.
Q. Is Metfil useful in the treatment of fragile X syndrome?
Metfil has shown promising results in some animal research studies in the treatment of fragile X syndrome. It may help in improving mental and behavioral disorders (autism) and control obesity and risk of developing diabetes in these patients. But these results are very preliminary and it is still not approved for the treatment of fragile X syndrome.
Q. What is the difference between liraglutide and Metfil?
Metfil and liraglutide are antidiabetic drugs and both control blood sugar levels effectively. Metfil is taken by oral route and it decreases glucose production from liver and glucose absorption from the gut and increases insulin sensitivity. While liraglutide is an injectable and it increases insulin release from the pancreas. Both cause stomach upset, like nausea, vomiting, diarrhea and bloating while liraglutide also increases the risk of pancreatitis.
Q. Does Metfil use make you feel high?
No, Metfil does not elevate the mood or make you feel high. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise. Rare side effects of Metfil include anxiety and depression.
Q. Does Metfil make you sweat?
Yes, sweating is one of the known side effects of Metfil. The exact cause of this is not known. Some researchers suggest it to be due to low blood sugar levels especially at night which can cause night sweats as well. Monitor your blood sugar levels regularly and talk to your doctor as your dose of Metfil may need to be adjusted.
Q. Can I take Metfil with clomiphene citrate?
Metfil can be taken with clomiphene citrate. They are advised together in patients with infertility along with polycystic ovarian syndrome (PCOS). Clinical studies have shown an improvement in ovulation and pregnancy rates in these patients as compared to use of clomiphene citrate alone or if the patients are resistant to the effects of clomiphene citrate. However, this is still under research.
Q. Is Metfil useful in treating or preventing breast cancer?
Metfil is seen to be useful in the treatment and prevention of cancers especially breast cancer in research studies. As high insulin levels are known to increase the risk of cancer, Metfil decreases cancer cell growth by decreasing insulin and blood glucose levels. However, its use in treating breast cancer is not yet approved.
Q. Does Metfil use increase your chance to get Helicobacter pylori infection?
No, Metfil is not associated with an increased risk of Helicobacter pylori infection. Diabetes itself increases the risk of H.pylori infection which increases the chances of stomach upset like nausea, vomiting, diarrhea, and bloating by Metfil.
Q. Does Metfil use leads to anemia?
Metfil may decrease the levels of vitamin B12 on long term use which may rarely cause a type of anemia in which blood cells are larger than normal (megaloblastic anemia). You may need to take foods rich in vitamin B12 like eggs, dairy products, and meat or a supplement from outside.
Q. Is Metfil useful in the treatment of prediabetes?
Metfil is seen to be useful in the management of prediabetes, a condition with blood glucose levels higher than normal but not high enough to label you as diabetic. Metfil makes the insulin already available in your body to work more effectively, decreases glucose production by liver and increases use of glucose by the muscles and lowers body weight. However, lifestyle modifications like a change in diet and exercise should be tried first as they are seen to be more effective than Metfil.
Q. Can I take Metfil with teneligliptin?
Yes, Metfil can be taken with teneligliptin. It is a good add-on treatment if the blood sugars are very high even after taking Metfil. The risk of low blood sugar levels (hypoglycemia) is also very low with both the medicines. However, consult your doctor before taking them together as a dose adjustment may be needed.
Information last updated by Dr. Varun Gupta, MD Pharmacology on 2nd Aug 2018.
The medicine details are for information purpose only. Consult a doctor before taking any medicine.
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