Medicine Overview of Maczole Tablet
Side effects of Maczole Tablet
Nausea, Abdominal pain, Diarrhoea, Constipation, Flatulence.
How to use Maczole Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. It can be taken with or without food, but it is better to take Maczole 150mg Tablet at a fixed time.
How Maczole Tablet works
Maczole 150mg tablet is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in relief of acid-related indigestion and heartburn.
In Depth Information on Maczole Tablet
Expert advice for Maczole Tablet
- Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention.
- Maczole can decrease magnesium levels in blood. Get your magnesium levels checked regularly. You may need a magnesium supplement or need to discontinue your medicine.
- Inform your doctor if you are suffering from osteoporosis as Maczole can weaken your bones by decreasing calcium levels in blood. You may need a calcium supplement, preferably calcium citrate.
- Maczole is a well-tolerated medicine and provides relief for a long time.
- It may take a few days to show its effect. You can take an antacid for a quick relief during this time unless your doctor has asked you not to use them.
- Once you start feeling better, do not stop taking your medicine. Take it for the duration as advised by your doctor
Special precautions for Maczole 150mg Tablet
Taking a large amount of alcohol can increase acidity and ca+more
use acid reflux in the food pipe causing heartburn. This would decrease the effect of this drug and can aggravate your underlying condition....
WEIGH RISKS VS BENEFITS
Maczole 150mg Tablet may be unsafe to use during pregnancy.+more
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor....
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Maczole 150mg Tablet is probably safe to use during lactatio+more
n. Limited human data suggests that the drug does not represent a significant risk to the baby....
Do not drive unless you are feeling well.+more
Maczole 150mg Tablet may cause dizziness and visual disturbances. This may affect your driving ability....
Maczole 150mg Tablet may cause dizziness and visual disturbances. This may affect your driving ability.
Maczole 150mg Tablet is safe to use in patients with kidney+more
disease. No dose adjustment of Maczole 150mg Tablet is recommended....
Maczole 150mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Maczole 150mg Tablet may be needed. Please consult your doctor.+more
A lower dose may be advised in patients with liver disease and who have to take this medicine for a long time....
A lower dose may be advised in patients with liver disease and who have to take this medicine for a long time.
Severely interacts with other drugs like
Mezolam 7.5mg Injection, Azivent 500mg Tablet, Zathrin Redimix Suspension, Pratham 200mg/5ml Suspension
If you miss a dose of Omeprazole, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Frequently asked questions for Maczole 150mg Tablet
Frequently asked questions for Omeprazole
Q. Can I take Maczole with domperidone?
Maczole can be safely taken with domperidone as no harmful effects have been reported clinically. A fixed-dose combination of these two medicines is also available. Domperidone works by increasing the gut motility and Rabeprazole decreases the acid production in the stomach. So, this combination is very effective in the treatment of reflux esophagitis associated with acidity, heartburn, intestinal and stomach ulcers.
Use of Maczole is contraindicated if you are allergic to this medicine or any other medicine belonging to the same class of drugs. Also, do not take Maczole if you are already taking a medicine containing nelfinavir (used for the treatment of HIV infection).
If you miss a dose of Maczole, take it as soon as you remember and the next dose as scheduled. However, if it is almost the time for your next dose, skip the missed dose and take your next dose and then follow the regular schedule. Do not take double the dose.
Maczole can be safely taken with oral contraceptive pills (birth control). They do not affect each other's action and no harmful effects have been seen when they are used together.
Maczole belongs to the group of medicines known as proton pump inhibitors (PPIs). This drug decreases the acid production in your stomach and is indicated for the treatment of conditions caused by excess acid secretion in the stomach.
Q. Is Maczole better than pantoprazole?
Maczole and pantoprazole both belong to the same class of drugs and are used in disease conditions with excess acid production like heartburn, acidity, stomach ulcers and intestinal ulcers. Both work by decreasing acid production in the stomach and are seen to be almost equally effective and safe in many clinical research studies. However, the response may vary from patient to patient and depend on the dose.
Maczole has been reported to cause subacute cutaneous lupus erythematosus in many studies. Common signs and symptoms of this disease include painful joints, tiredness, weakness, rash, fever, anemia, mouth ulcers, hair loss, and many others and these may get aggravated again and again. Talk to your doctor if you experience these side effects as you may need to discontinue this medicine.
Q. Is Maczole better than lansoprazole?
Maczole and lansoprazole are two different medicines belonging to the same class 'proton pump inhibitors'. Some studies mention that lansoprazole is more effective than Maczole for rapid relief of symptomatic heartburn. However, the effect of these medicines may vary upon individual response.
Q. Is Maczole better than probiotics?
Probiotics and Maczole perform different functions in the body. Maczole suppresses acid production in the stomach to prevent injury to the walls of the stomach and esophagus while probiotics help to prevent the overgrowth of harmful bacteria in the body, help to maintain a balance in the stomach between good and harmful bacteria and protect the stomach from infections. Probiotics and Maczole both are useful in the eradication of helicobacter pylori, which can cause stomach ulcers and also contribute to acid reflux.
Q. Can I take Maczole with ondansetron?
Ondansetron is an anti-emetic medicine which helps in relieving nausea (feeling sick) or vomiting. No harmful effects have been seen when Maczole is used with ondansetron. So, these two medicines can be taken together.
Lactose intolerance has been reported with the use of Maczole in some patients. Many Maczole preparations contain lactose as an ingredient. This is a digestive problem in which the patient cannot digest lactose, a type of sugar mainly found in milk and dairy products. The patient may complain of symptoms like flatulence (gas), diarrhea, bloating, stomach pain and feeling of being sick (nausea). Read the ingredients mentioned on the pack before taking the medicine.
Maczole can be taken with vitamin E. The combinations seems to have a beneficial effect in terms of better maintenance of moderate to severe esophagitis. However, there are not many studies or reports on this subject. Talk to your doctor for more information on this.
Q. Can I take Maczole with levosulpiride?
Maczole can be safely taken with levosulpiride as no harmful effects have been reported clinically. A fixed-dose combination of these two medicines is also available. Levosulpiride works by increasing the gut motility and Maczole decreases the acid production in the stomach. So, this combination is very effective in the treatment of reflux esophagitis associated with acidity, heartburn, intestinal and stomach ulcers.
Q. Is Maczole better than famotidine?
Maczole is a proton pump inhibitor (PPI) and famotidine is an H2 blocker. Both lowers the amount of acid in your stomach, treats heartburn, and heals ulcers. Studies have shown that Maczole is more effective than famotidine for the control of gastro-oesophageal reflux disease symptoms, in rapid healing of duodenal ulcers and achieving more rapid pain relief. However, the effect of these medicines may vary upon individual response.
Use of proton pump inhibitors (PPIs) like Maczole may be associated with an increased risk of Clostridium difficile–associated diarrhea (CDAD) as reported in few studies and informed by the US FDA as well. A possibility of CDAD can be there in patients taking PPIs and developed diarrhea that does not improve.
Maczole can be taken by cancer patients as prescribed by a doctor. Since cancer patients may also take many other medicines for the primary cancer treatment or for other symptoms and infections, there are chances of drug interactions with Maczole.
Take Maczole for as long as advised by your doctor. The duration of taking Maczole would vary depending on your condition. Do not stop taking this medicine without talking to your doctor.
Maczole can cause osteoporosis (thinning of bones) as it decreases the calcium absorption leading to calcium deficiency. This leads to an increased risk of bone fractures on long-term use, like hip, wrist or spine fractures. Inform your doctor if you have osteoporosis or if you are taking corticosteroids (these can increase the risk of osteoporosis) before starting your therapy. Take enough calcium and vitamin D to reduce the risk.
Rare side effects seen with the use of Maczole includes a decrease in white cells or platelets, allergic reactions, problems like blurred vision, wheezing, shortness of breath (bronchospasm), dry mouth, thrush, liver problems like jaundice, hair loss (alopecia), skin rash on exposure to sunshine, joint pains (arthralgia) or muscle pains (myalgia), severe kidney problems (interstitial nephritis), increased sweating and inflammation of the gut causing diarrhoea.
Proton (acid) pumps are found on the stomach mucosa and they are responsible for secreting acid in the stomach. Maczole works by blocking this gastric acid pump and this unique mechanism of action helps in decreasing the acid secretion in the stomach.
Maczole can rarely cause hepatitis with or without jaundice and very rarely it can lead to hepatic failure and encephalopathy in patients with the underlying liver disease. Maczole does not cause hepatitis B or any other viral hepatitis. However, there are studies showing an increased occurrence of hepatic encephalopathy in hepatitis B patients using PPIs. These medicines should be used with caution in patients with the underlying liver disease.
Q. Is Maczole better than dexlansoprazole?
Maczole and dexlansoprazole are two different medicines belonging to the same class of proton pump inhibitors. There are no studies which compare Maczole and dexlansoprazole. Maczole and dexlansoprazole have similar action, but their effect may vary in different patients.
Use of proton pump inhibitors like Maczole has been seen to be associated with an increase in chromogranin levels. This increase in chromogranin levels can be due to the effect of these drugs on enterochromaffin cells and this could also falsely increase the levels in patients with neuroendocrine tumours.
Use of proton pump inhibitors like Maczole has been recently linked with the development of dementia in elderly patients. As this risk of developing dementia is not confirmed, talk to your doctor for more information on this effect.
Maczole may cause vitamin B12 and vitamin C deficiency. When taken orally, vitamin B12 requires an acidic environment for its absorption from the stomach while Maczole causes a decrease the gastric acid secretion. You may need to take vitamin B12 supplements from outside. The clinical significance of the decrease in vitamin C levels is not known, so vitamin C supplementation is not recommended.
Yes, Maczole does expire. Please check the expiry date written on the pack and it refers to the last day of that month. Do not use Maczole after the expiry date.
Maczole before endoscopy in patients with gastrointestinal bleeding reduces the need for endoscopic therapy, the rate of post-endoscopy bleeding, and shortens hospital stays. Hence Maczole is given before endoscopy in patients with gastrointestinal bleeding.
Q. Is Maczole better than ranitidine?
Maczole is a proton pump inhibitor (PPI) and ranitidine is an H2 blocker. Both lowers the amount of acid in your stomach, treats heartburn, and heals ulcers. Studies have shown that Maczole is more effective than ranitidine in resolving heartburn in patients with gastroesophageal reflux disease (GERD), rapid healing of ulcers and prevent ulcers in patients who use nonsteroidal anti-inflammatory drugs (NSAIDs). However, the effect of these medicines may vary upon individual response.
Q. Are there any withdrawal symptoms associated with the use of Maczole?
There are no withdrawal symptoms seen when patients stop using Maczole as it has no habit forming tendencies.
Maczole can cause magnesium deficiency in the blood. Low magnesium levels is a rare side effect seen in patients treated with Maczole for at least three months and in most cases after a year of therapy. The patient may have symptoms like tetany, arrhythmias, and seizures and may need to stop this medicine and take magnesium from outside. Magnesium levels should be tested at regular intervals in the patients taking Maczole for a long duration.
Maczole is not a controlled substance. It is available when prescribed by a doctor.
Patients with cardiac disease can take Maczole. However, Maczole can interact with certain drugs (e.g clopidogrel, digoxin) which might be used by a patient with an underlying cardiac disease. Patients taking Maczole and digoxin may need to be monitored for digoxin toxicity. Maczole decreases the activation of clopidogrel, thus reducing its effects. Patients taking these medicines together needs to be monitored closely by a doctor.
Use of Maczole can cause iron deficiency and a decrease in hemoglobin levels as it decreases the acidic environment of the stomach needed for the absorption of iron. However, there are no recommendations on the regular monitoring of iron levels or taking iron supplements when the patient is taking Maczole.
Q. How is Maczole different from esomeprazole?
Maczole and esomeprazole both belong to the same class of drugs and are used in disease conditions with excess acid production like heartburn, acidity, stomach ulcers and intestinal ulcers. Esomeprazole is an S-isomer of Maczole. Studies have shown that esomeprazole provides more effective and rapid acid control than Maczole, without any increase in side effects and fewer variations in response between different patients.
Maczole is a not a narcotic substance and has not been reported to have any abuse potential. Maczole does not get you high and does not cause any addiction as no withdrawal symptoms have been reported when you stop taking this drug.
Maczole is a prescription medicine and you can buy this drug by providing a doctor's prescription. Maczole is not available as an over the counter (OTC) product.
Maczole is metabolized in the liver by the cytochrome P450 enzymes mainly CYP2C19. There could be an increase in the level of Maczole in patients with underlying liver disease because of a decrease in its metabolism. However, the amount of drug does not increase if given once a day.
Maczole can be used in stroke patients. There are studies suggesting that proton-pump inhibitors (PPIs) as a class are not associated with an increased short-term risk of recurrent stroke or death among older adults treated with clopidogrel after stroke.
Q. How is Maczole better than cimetidine?
Maczole is a proton pump inhibitor and cimetidine is an H2 receptor blocker. They act in different ways but both decrease the acid production in the stomach. However, Maczole is more potent, longer acting, and has fewer adverse effects when compared to cimetidine.
Q. Is Maczole better than rabeprazole?
Maczole and Rabeprazole belong to the same class of medicines known as proton pump inhibitors (PPIs) and work in the same way to decrease acid production in the stomach. However, few clinical studies have shown that rabeprazole provides better relief of the symptoms including the daytime pain of duodenal ulcers. The difference in response may also vary in different patients
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Substitutes for Maczole
No substitutes found for this medicine