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MACROZIDE 1000 MG TABLET

Tablet
MRP: Rs. 52.86 for 1 strip(s) (6 tablets each)
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Composition for MACROZIDE

Pyrazinamide(1000 mg)

food interaction for MACROZIDE

alcohol interaction for MACROZIDE

pregnancy interaction for MACROZIDE

lactation interaction for MACROZIDE

food
alcohol
pregnancy
lactation
It is better to take Macrozide 1000 mg tablet with food.
Interaction with alcohol is unknown. Please consult your doctor.
Macrozide 1000 mg tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
WEIGH RISKS VS. BENEFITS
Macrozide 1000 mg tablet is probably safe to use during breastfeeding. Please consult your doctor.
SAFE

SALT INFORMATION for MACROZIDE

Pyrazinamide(1000 mg)

Uses

Macrozide 1000 mg tablet is used in the treatment of tuberculosis (TB).

How it works

Macrozide 1000 mg tablet is an antibiotic. It kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis).

Common side effects

Vomiting, Nausea, Increased sensitivity to light, Abnormal liver function tests, Anemia, Joint pain, Difficulty in urination, Jaundice, Loss of appetite, Skin rash

Common Dosage for MACROZIDE 1000 MG TABLET

Patients taking MACROZIDE 1000 MG TABLET

  • 80%
    Once A Day
  • 20%
    Twice A Day

SUBSTITUTES for MACROZIDE

5 Substitutes
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Top Physicians

  • Dr. M. K. Singh
    MBBS, MD
    4.8
  • Dr. Prabhat Kumar Jha
    MBBS, MD
    4.7
  • Dr. Sushila Kataria
    MBBS, MD, Diploma
    4.6
  • Dr. R. S. Rawat
    MBBS, MD
    4.5
  • Dr. Kartavya Shah
    MBBS, DNB
    4.2

Expert advice for MACROZIDE

  • Avoid alcoholic beverages while taking this drug.
  • Do not have any immunizations/vaccinations while using this medication without the consent of your doctor.
  • Contact your doctor immediately if you experience symptoms such as persistent nausea,  vomiting, feeling of discomfort (malaise) or jaundice (abnormal liver function causing yellowing of skin and eyes) while taking pyrazinamide. It indicates that you are developing liver disease.
  • Constant monitoring of liver function (especially levels of enzymes aspartate transferase [AST] and alanine transferase [ALT]) and blood uric acid levels is advised while on treatment with pyrazinamide.
  • Do consult your doctor before taking pyrazinamide if you are pregnant or planning to become pregnant.
  • Do not use pyrazinamide, if you are breast-feeding.
  • Do not stop taking pyrazinamide without consulting your doctor.
  • If you forget to take a dose of pyrazinamide, take it as soon as you remember. Do not double the dose to make up for the missed dose.
  • Do consult your doctor if you are taking oral contraceptive medications (hormonal birth control pills) for birth control. Your doctor may ask you to use other means of birth control (eg. condom, diaphragm with spermicide) to prevent pregnancy while taking pyrazinamide.

Frequently asked questions for MACROZIDE

Pyrazinamide

Q.What is pyrazinamide and what is it used for?
Pyrazinamide is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis

Q.Is pyrazinamide bactericidal?
Pyrazinamide is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases

Q.How does pyrazinamide work/treat tuberculosis?
Pyrazinamide kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis). The exact mechanism of action for pyrazinamide is not known

Q.How does pyrazinamide cause hyperuricemia and gout?
Following oral intake of pyrazinamide, it gets converted in the body to pyrazinoic acid (active chemical form of pyrazinamide). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).

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Content on this page was last updated on 28 September, 2016, by Dr. Varun Gupta (MD Pharmacology)