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MD (Pharmacology), MBBS
Last updated:
19 Nov 2020 | 08:12 PM (IST)
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Luprolide 3.75mg Injection

Prescription Required
Manufacturer
SALT COMPOSITION
Salt Synonyms
Storage
Store in a refrigerator (2 - 8°C). Do not freeze.

Introduction

Luprolide 3.75mg Injection is used in the treatment of prostate cancer. It is also used to treat endometriosis (endometrium of the uterus grows excessively and causes symptoms like pain, heavy or irregular periods), uterine fibroids and central precocious puberty (very early puberty).

Luprolide 3.75mg Injection is given as an injection under the skin by a qualified medical professional.  Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Decreased libido, increased sweating, fatigue, muscle weakness, and hot flashes are some very common side effects of this medicine. The long-term use of medicine may cause weakened bones and a reduction in bone mineral density. You are advised to take vitamin D and calcium supplements while taking this medicine. It might cause menstrual periods to stop for a period of 7- 12 weeks, inform your doctor if menstrual bleeding continues even during the treatment.

Before taking this medicine, inform your doctor if you have a history of drinking alcohol, smoking, and osteoporosis. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Luprolide Injection

Benefits of Luprolide Injection

In Prostate cancer

Prostate gland is a small walnut-sized gland that produces a fluid called seminal fluid that nourishes and transports sperms in males. The most common symptom of prostate cancer is difficulty with urination, but sometimes there are no symptoms at all. Luprolide 3.75mg Injection decreases or stops the growth of cancer cells by decreasing the amount of testosterone (natural hormone in males) in men. This also relieves difficulty in passing urine and makes it easier for you to urinate.

In Endometriosis

Endometriosis is a condition where tissue like the lining of the womb starts to grow in other places. The main symptoms include pain in your lower stomach or back, period pain, pain during and after sex, constipation, diarrhea and feeling sick. It can also make it difficult to get pregnant. Luprolide 3.75mg Injection works by preventing the lining of your womb and any endometriosis tissue from growing too quickly. This will help relieve the symptoms you may have. This medicine needs to be taken regularly to be effective and you may need other medicines or procedures to help control endometriosis.

In Uterine fibroids

Benefits
Benefits
100%
12

Uterine fibroids are non-cancerous growths of the uterus that often appear during childbearing years. Luprolide 3.75mg Injection helps control the symptoms associated with uterine fibroids such as excessive menstrual bleeding, lower back pain, and also reduces the size of the existing fibroids. It blocks the action of the enzyme responsible for the growth of the broids. As a result they decrease in size and also stop growing further.

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Uterine fibroids are non-cancerous growths of the uterus that often appear during childbearing years. Luprolide 3.75mg Injection helps control the symptoms associated with uterine fibroids such as excessive menstrual bleeding, lower back pain, and also reduces the size of the existing fibroids. It blocks the action of the enzyme responsible for the growth of the broids. As a result they decrease in size and also stop growing further.

In Precocious puberty (premature puberty)

When puberty (change of a child’s body to adult structure and size) begins before age 8 in girls and before age 9 in boys, it is considered precocious puberty. Luprolide 3.75mg Injection helps delay this early onset of adulthood and limits the onset of precocious puberty. However, this medicine is given by a doctor and should not be self-administered. Follow your doctor’s instructions carefully for the most benefit.

Side effects of Luprolide Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Luprolide

  • Decreased libido
  • Testicular atrophy
  • Increased sweating
  • Fatigue
  • Muscle weakness
  • Erectile dysfunction
  • Bone pain
  • Injection site reaction
  • Hot flashes

How to use Luprolide Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Luprolide Injection works

Luprolide 3.75mg Injection is a hormone similar to the one produced by a hypothalmus gland in the brain. It works by decreasing the blood levels of testosterone in males.

Safety Advice

Alcohol
CAUTION
Caution is advised when consuming alcohol with Luprolide 3.75mg Injection. Please consult your doctor.
Pregnancy
UNSAFE
Luprolide 3.75mg Injection is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breastfeeding
CONSULT YOUR DOCTOR
Information regarding the use of Luprolide 3.75mg Injection during breastfeeding is not available. Please consult your doctor.
Driving
UNSAFE
Luprolide 3.75mg Injection may cause side effects which could affect your ability to drive.
Do not drive or operate machinery if you experience drowsiness, dizziness or visual disturbances whilst being treated with Luprolide 3.75mg Injection.
Kidney
CONSULT YOUR DOCTOR
There is limited information available on the use of Luprolide 3.75mg Injection in patients with kidney disease. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Luprolide 3.75mg Injection in patients with liver disease. Please consult your doctor.

What if you forget to take Luprolide Injection?

If you miss a dose of Luprolide 3.75mg Injection, please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Luprolide 3.75mg Injection
₹4611.0/Injection
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Quick Tips

  • Luprolide 3.75mg Injection helps in the treatment of locally advanced or metastatic prostate cancer.
  • It may also be used to treat endometriosis and uterine fibroids.
  • It is given as an injection either under the skin or into a muscle.
  • It may cause dizziness and visual disturbances. Don't drive or do anything that requires mental focus until you know how it affects you.
  • It will cause menstrual periods to stop. Periods will resume 7-12 weeks after the final injection. Consult your doctor if you experience menstrual bleed despite treatment. 
  • Use non-hormonal methods of contraception such as condoms to prevent pregnancy during treatment, as this medicine may be harmful to a developing baby.
  • Long term treatment may lead to bone loss and a higher risk of bone fractures, especially if you are a heavy drinker, a smoker, or have a family history of osteoporosis.

Fact Box

Chemical Class
GNRH Analogue
Habit Forming
No
Therapeutic Class
GYNAECOLOGICAL

Patient Concerns

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In which age does the girls have hairs in their undearms
Dr. Sunil Sekhri
Diabetology
During Puberty and the age range varies
Size of penish does not increase
Dr. Praveen Pushkar
Urology
Size of penis will not increase after puberty
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FAQs

Q. Is Luprolide 3.75mg Injection a chemotherapy medicine?

No, Luprolide 3.75mg Injection is not a chemotherapy medicine. Luprolide 3.75mg Injection is a synthetic hormone analogue medicine which is used for the treatment of hormone-dependent conditions in men and women.

Q. Does Luprolide 3.75mg Injection stop periods?

Yes, the periods tend to stop while taking Luprolide 3.75mg Injection injections as this medicine alters the reproductive hormones in females. Sometimes, there can be vaginal bleeding in few cases. If this occurs, please contact your doctor to get yourself assessed and follow the direction of your doctor.

Q. Is Luprolide 3.75mg Injection a hormonal medicine and can it be given in pregnancy?

Yes, Luprolide 3.75mg Injection is a hormonal medicine which alters the reproductive hormones when given in females. This medication is not recommended for use in women who are or may become pregnant because this can harm the fetus in the womb. Using this medicine during pregnancy may also lead to abortion of the baby. Do inform your doctor if you are pregnant or are planning to get pregnant before starting this medication.

Q. Can taking Luprolide 3.75mg Injection affect my bones?

Yes, there are chances of Luprolide 3.75mg Injection affecting your bones. Using Luprolide 3.75mg Injection may cause a decrease in bone mineral density and make the bones weaker. In women, bone density should be assessed before starting the treatment. Special care and monitoring should be done in women with increased risk of osteoporosis. If at all needed, additional medicines may be given to prevent the development of osteoporosis in patients with decreased bone mineral density.

Q. Can Luprolide 3.75mg Injection cause diabetes or increased blood sugar?

Yes, Luprolide 3.75mg Injection may cause an increase in blood sugar levels, worsening the blood glucose control in patients with diabetes. It can even increase the risk of developing diabetes. Therefore, you must monitor the blood glucose and/or glycosylated hemoglobin (HbA1c) from time to time to keep a track of the glucose control and inform your doctor in case you develop any problem. Diabetic patients when prescribed this medication should monitor the sugar levels more frequently while taking this treatment.

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 959.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 787-88.
  3. Leuprorelin acetate. Wooburn Green, High Wycombe: Takeda UK Ltd.; 2011 [revised 11 Jun. 2018]. [Accessed 25 Jan. 2019] (online) Available from:External Link
  4. Leuprolide Leuprorelin acetate. Fort Collins: TOLMAR Inc.; 2002 [revised Feb. 2016]. [Accessed 26 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India
Expires on or after: March, 2021

A licensed vendor partner from your nearest location will deliver Luprolide 3.75mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
MRP4611  Get 15% OFF
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₹3919.35
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1 Injection in 1 vial
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