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Composition FOR LEUKERAN

Chlorambucil(2 mg)

food interaction for LEUKERAN

alcohol interaction for LEUKERAN

pregnancy interaction for LEUKERAN

lactation interaction for LEUKERAN

food
alcohol
pregnancy
lactation
It is better to take Leukeran tablet empty stomach (1 hour before food or 2 hours after food).
Interaction with alcohol is unknown. Please consult your doctor.
Leukeran tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
WEIGH RISKS VS. BENEFITS
Leukeran tablet is probably unsafe to use during breastfeeding. Please consult your doctor.
UNSAFE

SALT INFORMATION FOR LEUKERAN

Chlorambucil(2 mg)

Uses

Leukeran tablet is used in the treatment of Hodgkin’s disease (a cancer of the lymph glands) and blood cancer

How it works

Leukeran tablet works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.

Common side effects

Rash, Urine discolouration, Reduced blood platelets, Headache, Dizziness, Convulsion, Myelosuppression, Coordination disorder, Frequent urge to urinate, Increased magnesium level in blood, Shortness of breath, Nasal congestion, Yellow discoloration of eye, Vomiting, Weakness, Insomnia, Sleepiness, Mouth ulcer, Allergic skin rash, Nausea, Decreased potassium level in blood, Abdominal pain, Infection, Sticky stools, Loss of appetite, Bone-marrow suppression, Brain swelling, Decreased white blood cell count, Yellow discoloration of skin, Cns toxicity, Hair loss, Absence of menstrual periods, Fatigue, Sore throat, Fever, Anxiety, Increased liver enzymes, Anemia, Sore mouth, Hallucination, Thrombophlebitis, Bleeding, Diarrhoea, Blood in urine, Depression, Vertigo, Speech disorder, High grade fever, Dark colored urine, Cough, Unusual lumps or masses, Confusion, Mucosal inflammation, Drowsiness, Gastritis, Decreased white blood cell count (neutrophils), Bruise, Constipation, Stomatitis, Uncoordinated body movements, Decreased white blood cell count (lymphocytes), Viral infection, Increased glucose level in blood

SUBSTITUTES FOR LEUKERAN

2 Substitutes
2 Substitutes
Sorted By
RelevancePrice
  • CLOKERAN 2MG TABLET
    (30 tablets in strip)
    Natco Pharma Ltd
    Rs. 48.98/tablet
    Tablet
    Rs. 1469.39
    pay 220% more per tablet
  • CELKERAN 2MG TABLET
    (30 tablets in strip)
    Celon Laboratories Ltd
    Rs. 39.68/tablet
    Tablet
    Rs. 1190.47
    pay 160% more per tablet

Expert advice FOR LEUKERAN

  • Do not receive live vaccine (such as measles, mumps, rubella and others) while using chlorambucil, and avoid contact with anyone who has recently received a live vaccine as there are chances that the virus could be passed on to you.
  • You may be regularly monitored for blood count while taking chlorambucil.
  • Do not take chlorambucil if you have recently undergone radiotherapy or received other cytotoxic agents.
  • Caution has to be followed if you have a liver or kidney problems. 
  • Regular monitoring is required if your child is having nephrotic syndrome; or if you have been prescribed high pulse dosing regimens and have a history of seizure disorder.
  • Do not take chlorambucil if you have rare hereditary problems of glucose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medication.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions FOR LEUKERAN

Chlorambucil

Q.

What is chlorambucil used for?
Chlorambucil is used to treat some types of blood cancers like Hodgkin's disease (cancer that starts in blood cells that are part of immune system), certain forms of non-Hodgkin's lymphoma, chronic lymphocytic leukemia (disease where the bone marrow produces a large number of abnormal white cells. It is also used to treat Waldenstrom's macroglobulinaemia (rare blood condition involving the release of an abnormal protein, macroglobulin, into the blood)

Q.

How is chlorambucil administered?
Chlorambucil is administered orally in tablet form

Q.

How is chlorambucil excreted?
Chlorambucil is metabolized in liver to form nontoxic compounds which are excreted in urine

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Q.

Why is chlorambucil toxic to cancer cells/ how does chlorambucil work?
Chlorambucil belongs to a class of drugs called nitrogen mustard derivatives which kill the cancer cells by interfering with DNA replication, and also by directly slowing or stopping their growth

Q.

Does chlorambucil need to be refrigerated?
Chlorambucil has to be stored in a refrigerator at 2 °C – 8 °C

Q.

Does chlorambucil cause hair loss/constipation?
No, hair loss or constipation has not been reported with the use of chlorambucil.

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Content on this page was last updated on 03 February, 2017, by Dr. Varun Gupta (MD Pharmacology)