Janumet 50 mg/1000 mg Tablet

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MSD Pharmaceuticals Pvt Ltd

Composition for Janumet 50 mg/1000 mg Tablet

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Primarily used for

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Alcohol
375
₹25.0/Tablet
15 tablets in 1 strip
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Medicine Overview of Janumet 50 mg/1000 mg Tablet

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Uses of Sitagliptin

Sitagliptin is used in the treatment of type 2 diabetes
It is used in addition to diet and exercise to improve blood sugar control in adults with type 2 diabetes.
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Side effects of Sitagliptin

Common

Headache, Upper respiratory tract infection, Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea, Nasopharyngitis.

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How to use Sitagliptin

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. It is better to take Janumet 50 mg/1000 mg Tablet with food.

How Janumet 50 mg/1000 mg Tablet works

Sitagliptin is an anti-diabetic medication. It works by increasing the release of insulin from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces the fasting and postmeal sugar levels.
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Uses of Metformin

Metformin is used in the treatment of type 2 diabetes.
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Side effects of Metformin

Common

Nausea, Vomiting, Altered taste, Diarrhoea, Abdominal pain, Loss of appetite.

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How to use Metformin

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. It is better to take Janumet 50 mg/1000 mg Tablet with food.

How Janumet 50 mg/1000 mg Tablet works

Metformin is an anti-diabetic medication. It lowers the production and absorption of glucose in your body and allows better use of existing insulin.

In Depth Information on Janumet 50 mg/1000 mg Tablet

Expert advice for Sitagliptin

  • Sitagliptin can be taken with or without food.
  • Chances of weight gain and low blood sugar are lesser as compared to other diabetes medicines.
  • Get your blood sugar monitored regularly.
  • Inform your doctor immediately if you have severe stomach pain, nausea, and/or vomiting. These could be symptoms of pancreatitis.
  • Inform your doctor immediately if you have severe joint pain.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Sitagliptin 

Expert advice for Metformin

  • Metformin is the medicine of choice to lower blood sugar levels.
  • Chances of weight gain and low blood sugar are lesser as compared to other diabetes medicines.
  • An upset stomach with nausea and diarrhoea may occur in the first two weeks; take it with food to avoid an upset stomach.
  • Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.
  • Notify your doctor if you have a kidney disease. Your doctor may adjust your dose.
  • Vitamin B12 deficiency and symptoms of anemia like fatigue, pale skin, shortness of breath or headache may occur. Notify your doctor if you experience any of these as you may require supplements.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Metformin.
Warnings
Special precautions for Janumet 50 mg/1000 mg Tablet
Alcohol
CAUTION
Taking Sitagliptin with alcohol may affect blood glucose levels in patients with diabetes.

Taking metformin with alcohol can cause lactic acidosis and you may experience malaise, respiratory distress, slow or irregular heartbeat, sleepiness, stomach upset, or other unusual symptoms.
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Pregnancy
PROBABLY SAFE
Janumet 50 mg/1000 mg Tablet is probably safe to use during pregnancy.

Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.
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Lactation
Janumet 50 mg/1000 mg Tablet is probably safe to use during
lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.
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Driving
Your ability to drive may be affected if your blood sugar is
low or high. If this happens, do not drive.
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Kidney
CAUTION
Janumet 50 mg/1000 mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Janumet 50 mg/1000 mg Tablet may be needed. Please consult your doctor.

Use of Janumet 50 mg/1000 mg Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
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Liver
Janumet 50 mg/1000 mg Tablet is probably safe to use in pati
ents with liver disease. Limited data available suggests that dose adjustment of Janumet 50 mg/1000 mg Tablet may not be needed in these patients. Please consult your doctor.
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Patient Concerns

Frequently asked questions for Janumet 50 mg/1000 mg Tablet

Frequently asked questions for Sitagliptin

Q. Is Sitagliptin a statin?
No, Sitagliptin is not a statin. Sitagliptin is an antidiabetic drug and it belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors. while Statin is a class of lipid-lowering drugs.
Q. Is Sitagliptin safe?
Sitagliptin is safe to use when taken for a prescribed duration in the dose advised by a doctor. However, you can experience some common side effects at the prescribed dose also, like a headache, upper respiratory tract infection, nasopharyngitis and hypoglycemia (Low blood sugar level) when used along with insulin or sulphonylureas.
Q. Is Sitagliptin a blood thinner?
No, Sitagliptin is not a blood thinner. Sitagliptin is an antidiabetic drug and it belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors.
Q. Is Sitagliptin better than teneligliptin?
Sitagliptin and Teneligliptin belong to the same class of drugs. They have a similar mechanism of action and efficacy to control blood sugar levels. However, Teneligliptin is safe to use in patients with underlying kidney disease while a dose adjustment of Sitagliptin is needed in patients with moderate to severe kidney disease.
Q. When can I stop taking Sitagliptin ?
Do not stop taking Sitagliptin until advised by your doctor as this can lead to a sudden rise in your blood sugar levels. However, in case you experience stomach pain while taking Sitagliptin, immediately stop taking it and inform your doctor. Follow all directions given to you by your doctor carefully.
Q. How is Sitagliptin different from dapagliflozin?
Both Sitagliptin and Dapagliflozin are antidiabetic drugs, but they work in different ways. Dapagliflozin is seen to be more effective in controlling blood sugar levels and helps in weight loss while Sitagliptin is weight neutral. They also differ in their side effect profile as the use of Sitagliptin is associated with nausea, nasopharyngitis, and pancreatitis while Dapagliflozin commonly causes urinary and genital tract infections.
Q. How is Sitagliptin different from vildagliptin?
Sitagliptin and Vildagliptin belong to the same class of anti-diabetic drugs. However, Vildagliptin is seen to be more effective in controlling blood sugar levels with less fluctuations compared to Sitagliptin. But Vildagliptin is to be taken twice a day while Sitagliptin is taken once a day.
Q. Does Sitagliptin interact with other drugs?
Sitagliptin is an antidiabetic medicine and its interaction with other drugs is very limited. Sitagliptin itself is less likely to cause hypoglycemia (low blood sugar), however, when taken with other anti-diabetic medicines, the risk increases. Also, Sitagliptin can increase the blood levels of digoxin which can lead to more side effects with digoxin.
Q. How is Sitagliptin different from pioglitazone?
Sitagliptin and pioglitazone are antidiabetic drugs with different actions and have different side effect profile. Pioglitazone is seen to cause edema (water retention is tissues), weight gain and can increase the risk of heart failure. On the other hand, use of Sitagliptin is seen to be associated with pancreatitis.
Q. Does Sitagliptin have any role in the management of polycystic ovarian syndrome (PCOS)?
Sitagliptin along with metformin is used off-label for the treatment of polycystic ovarian syndrome (PCOS) as it has shown efficacy in this condition in some clinical studies. However, its use in PCOS is yet not approved. Please consult your doctor.
Q. Can I use Sitagliptin with rosuvastatin?
Yes, Sitagliptin can be used with rosuvastatin. No drug-drug interactions or any change in side effect profile has been reported compared to when they are used alone.
Q. How is Sitagliptin different from voglibose?
Both Sitagliptin and voglibose are antidiabetic drugs but they belong to different classes and have different side effect profiles. Voglibose commonly causes rash, flatulence, abdominal pain and diarrhea whereas Sitagliptin is commonly seen to cause headache, upper respiratory tract infection and hypoglycemia when taken with other antidiabetic drugs.
Q. How is Sitagliptin different from empagliflozin?
Both Sitagliptin and Empagliflozin are antidiabetic drugs, but they work in different ways. Empagliflozin is seen to be more effective in controlling blood sugar levels and helps in weight loss while Sitagliptin is weight neutral. They also differ in their side effect profile as the use of Sitagliptin is associated with nausea, nasopharyngitis, and pancreatitis while Empagliflozin commonly causes urinary and genital tract infections.
Q. What is the difference between Sitagliptin and canagliflozin?
Both Sitagliptin and Canagliflozin are antidiabetic drugs, but they work in different ways. Canagliflozin is seen to be more effective in controlling blood sugar levels and helps in weight loss while Sitagliptin is weight neutral. They also differ in their side effect profile as the use of Sitagliptin is associated with nausea, nasopharyngitis, and pancreatitis while Canagliflozin commonly causes urinary and genital tract infections.
Q. How is Sitagliptin different from liraglutide?
Both Sitagliptin and liraglutide are antidiabetic drugs but they work in different ways. Liraglutide is more effective in controlling blood sugar levels and also help to lower body weight compared to Sitagliptin which is weight neutral. Moreover, liraglutide is available as an injectable whereas Sitagliptin is an oral medication.
Q. Can I take Sitagliptin with Metformin?
Yes, Sitagliptin can be taken with Metformin. It is a good add-on treatment if the blood sugars are very high even after taking Metformin and the risk of low blood sugar levels (hypoglycemia) does not become very high when they are taken together. However, a dose adjustment of the two may be needed.
Q. Can I take Sitagliptin with insulin?
Yes, you can take Sitagliptin with insulin. Using them together can lower the insulin dose and decrease the risk of hypoglycemia (low blood sugar levels).
Q. How is Sitagliptin different from Glipizide?
Both Sitagliptin and Glipizide are antidiabetic drugs but they belong to different classes and have different side effect profiles. Glipizide commonly causes hypoglycemia and weight gain while Sitagliptin is commonly associated with a headache and nasopharyngitis.
Q. How is Sitagliptin different from Glimepiride?
Both Sitagliptin and Glimepiride are antidiabetic drugs but they belong to different classes and have different side effect profiles. Glimepiride commonly causes hypoglycemia and weight gain while Sitagliptin is commonly associated with a headache and nasopharyngitis.
Q. Can I take Sitagliptin with Glipizide?
Yes, Sitagliptin can be taken with Glipizide. Both are antidiabetic drugs but they work in different ways. When taken together, they can help in better control of blood sugar levels. However, the risk of low blood sugar levels (hypoglycemia) can increase if the dose of glipizide is not adjusted.
Q. Is it beneficial to use Sitagliptin with liraglutide?
No, it is not advisable to take Sitagliptin with Liraglutide. Both work by increasing the level of incretin hormones and can be expected to have a better efficacy but, there could also be an increased risk of side effects like pancreatitis when they are used together.
Q. Does Sitagliptin cause weight loss?
Use of Sitagliptin is not associated with either weight loss or weight gain. It is weight neutral.
Q. Does the use of Sitagliptin cause hypoglycemia (low blood sugar levels)?
Sitagliptin can lower blood sugar level (hypoglycemia). However, it happens more often if you delay or miss your food, do more than routine exercise, drink alcohol or take other antidiabetic medicine along with. Be cautious of the symptoms of hypoglycemia and always keep glucose tablets or honey or fruit juice with you. Regular monitoring of blood sugar levels is important.
Q. Is the use of Sitagliptin associated with cancer?
Sitagliptin belongs to the group of drugs called incretins which have been associated with pancreatic cancer in some clinical studies. However, a definite evidence is missing, so, it is advisable to talk to your doctor regarding the same.
Q. Does the use of Sitagliptin associated with constipation?
Yes, constipation is an uncommon side effect seen with the use of Sitagliptin. Taking a fiber rich diet and plenty of water can help in relieving constipation.
Q. Can Sitagliptin cause somnolence (makes you feel sleepy)?
Yes, somnolence (sleepiness) has been reported with the use of Sitagliptin. Also, there could also be an increased risk of hypoglycemia (very low blood sugar levels) when used with other antidiabetic drugs which can make you feel dizzy. Be careful while driving or when operating a machine.
Q. Can Sitagliptin cause itching?
Sitagliptin is not known to cause itching. However, in case you develop an allergic reaction to Sitagliptin or any of its ingredients, you may have symptoms of itching, redness or swelling of the mouth, lips, tongue or throat. Immediately stop taking the medicine and inform or visit a doctor.
Q. Does Sitagliptin cause dry mouth?
No, the use of Sitagliptin is not seen to be associated with dry mouth.
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Frequently asked questions for Metformin

Q. Is Metformin helpful in patients with polycystic ovarian syndrome (PCOS)?
Metformin is commonly used off-label for the treatment of polycystic ovary syndrome (PCOS). It regulates ovulation and androgen levels in the body which improves menstrual cycles and pregnancy rates and outcomes in these patients. It also improves the insulin sensitivity and prevents the development of gestational diabetes and type 2 diabetes mellitus commonly seen in these patients.
Q. How does Metformin help in weight loss?
Metformin helps in weight loss by decreasing hunger (appetite) and hence food intake. It makes the insulin already available in your body to work more effectively. This leads to decrease glucose production, increase glucose use and decreased fat deposits which further helps to lower body weight. However, it is not yet approved for weight loss, this is an off-label use.
Q. Is Metformin useful in the treatment of infertility?
Metformin is commonly used off-label for the treatment of infertility associated with polycystic ovary syndrome (PCOS). It regulates ovulation and androgen levels in the body and improves menstrual regularity and pregnancy rates and outcomes. This beneficial effect is thought to be due to improvement in insulin resistance by Metformin.
Q. Does Metformin cause low blood sugar levels (hypoglycemia)?
Metformin can lower blood sugar level (hypoglycemia). It happens more often if you delay or miss your food, do more than your routine exercise, drink alcohol or take other antidiabetic medicine along with. So, regular monitoring of blood sugar level is important and be cautious of symptoms of hypoglycemia and always keep glucose tablets, honey or fruit juice with you.
Q. Can I take Metformin forever?
Metformin is generally a safe and well-tolerated drug even on long-term use. However, its long-term use can cause vitamin B12 deficiency leading to anemia and peripheral neuropathy (nerve damage). so, it should be taken only at prescribed doses for the duration as advised by the doctor.
Q. Is Metformin a sulfonylurea?
No, Metformin is not a sulfonylurea. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise.
Q. Is Metformin a steroid?
No, Metformin is not a steroid. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modifications in diet and exercise.
Q. Does Metformin cause bloating?
Metformin commonly causes stomach upset like bloating (heavy and uncomfortable feeling in the stomach), nausea, vomiting, and diarrhea. To avoid these side effects, it is advised to be taken after meals, preferably started at a low dose and then increased slowly over weeks, or by using slow-release tablets.
Q. Is Metformin good for fatty liver?
Metformin is seen to be beneficial in the treatment of non-alcoholic fatty liver disease (NAFLD). One of the underlying cause of NAFLD is insulin resistance. Metformin improves insulin resistance and liver enzymes in these patients. It is not seen to benefit patients of alcoholic fatty liver disease and is usually avoided in patients with liver cirrhosis as they are at an increased risk of lactic acidosis.
Q. What is the benefit of combining Metformin with coenzyme q10?
Coenzyme Q10 is an antioxidant that helps in energy production and is found in heart, liver, kidney, and pancreas (which produces insulin). It can repair the damage caused to these organs by free radicals. Low levels of CoQ10 are seen in patients with diabetes. So, some researchers suggest it be given from outside. It can be taken with Metformin as no drug-drug interactions or harmful effects have been seen between the two.
Q. Does Metformin help in improving your menstrual cycle (periods)?
Yes, Metformin does improve menstrual cycle (periods) regularity in women with polycystic ovarian syndrome (PCOS). It is associated with insulin resistance, decreased ovulation, and high androgen levels which cause menstrual irregularities like delayed periods and scanty bleeding. Metformin helps in regularizing menstrual cycles by improving insulin sensitivity, ovulation rate, and decreasing androgen levels.
Q. Can I take Metformin with atorvastatin?
Yes, Metformin can be taken with atorvastatin. There are no reported harmful effects when they are used together. Rather some studies suggest beneficial effects in diabetics as they may prevent a very high increase in blood glucose after food, decrease some inflammation markers and protect the patients from liver injury.
Q. Can I take Metformin with phentermine?
Metformin can be taken with phentermine. These are sometimes given together in obese patients who are also diabetic and are taking Metformin along with exercise and diet modification. Phentermine decreases food intake by its action in the brain. However, phentermine can decrease the effect of Metformin leading to very high blood glucose levels. So, a dose adjustment of Metformin may be needed.
Q. Can I take Metformin with levothyroxine?
Metformin can be taken with levothyroxine but the dose of Metformin may need to be adjusted. Levothyroxine can decrease the effect of Metformin leading to very high blood glucose levels. These are used together in patients with coexisting thyroid disease and diabetes mellitus or polycystic ovarian syndrome (PCOS).
Q. Can I take Metformin with prednisolone?
Metformin can be taken with prednisolone but the dose of Metformin may need to be adjusted. Prednisolone can decrease the effect of Metformin leading to very high blood glucose levels. Continuous use of steroids like prednisolone can also cause diabetes known as glucocorticoid-induced diabetes and use of Metformin is recommended in these patients.
Q. Can I take Metformin with metoprolol?
Metformin can be taken with metoprolol. There are no reported drug interactions or harmful effects in humans when they are used together. However, some animal studies suggest that metoprolol can decrease the blood levels of Metformin and on long-term use can increase lactic acid and uric acid levels.
Q. Does Metformin clear acne?
Metformin is not indicated for clearing acne due to just any condition. It only helps in clearing acne in women with polycystic ovarian syndrome (PCOS) along with other problems like facial hair, abdominal obesity, and irregular menstruation.
Q. Does Metformin cause hair loss?
No, hair loss has not been reported with Metformin. It only helps in clearing facial hair (hirsutism) in women with polycystic ovarian syndrome (PCOS) along with other problems like acne, abdominal obesity, and irregular menstruation.
Q. Does Metformin cause weight gain?
No, weight gain has not been reported with Metformin. Rather it helps in decreasing weight especially abdominal fat patients of type 2 diabetes mellitus and in women with polycystic ovarian syndrome (PCOS) along with other problems like facial hair, acne, and irregular menstruation.
Q. Does Metformin cause constipation?
Metformin is not known to cause constipation. Some common side effects associated with the use of Metformin includes nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite.
Q. Is Metformin safe?
Metformin is a safe and well-tolerated drug even on long-term use when taken strictly as advised by the doctor. However, there are some very common side effects like nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite you may experience even at therapeutic doses.
Q. Does Metformin increase blood pressure?
Metformin is not known to increase blood pressure. Some common side effects associated with the use of Metformin includes nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite.
Q. Is Metformin an insulin?
No, Metformin is not an insulin. Metformin is an oral drug used in type 2 diabetes mellitus and lowers blood glucose levels by decreasing its production and increasing absorption and making the already available insulin in your body to work better. Insulin is a normally produced hormone in the body, used in the injectable form in the treatment of both type 1 and 2 diabetes mellitus and it works by absorbing and storing glucose from the blood.
Q. Is Metformin a banned drug?
No, Metformin is not a banned drug. It is a prescription medicine and is available when prescribed by registered medical practitioner.
Q. Is Metformin a birth control pill?
No, Metformin is not a birth control pill. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise.
Q. Is Metformin a statin?
No, Metformin is not a statin. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise.
Q. Can I take Metformin with saxagliptin?
Both Metformin and saxagliptin are anti diabetic drugs and can be used together. Their fixed dose combinations are also available and commonly advised once Metformin is unable to control blood sugar levels even after giving the maximum tolerated dose. As they work by different mechanisms, they help in better control of blood sugar levels compared to either drug taken alone.
Q. Does Metformin cause blurry vision?
Metformin is not known to cause blurred vision. Change in vision in a patient with diabetes could be due to multiple reasons. It could be a temporary problem either due to high blood sugar levels which cause your lens inside your eye to swell and change your vision. If the blurred vision continues for a long time, consult a doctor.
Q. What is lactic acidosis and how is it related to Metformin use?
Lactic acidosis is a rare, but serious complication associated with the use of Metformin. Patient has high blood lactic acid levels and may present with tiredness, weakness, stomach pain, loose stools, severe muscle pain, muscle cramps and difficulty in breathing. It is especially seen in old age patients, those with kidney, liver or heart disease, or who take large amounts of alcohol. If you have these symptoms, stop taking Metformin and consult your doctor.
Q. Is Metformin use associated with liver pain?
Metformin is not known to cause any liver pain or damage. Rather, it is seen to be useful in patients with non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C. However, it is usually avoided in patients with liver cirrhosis as they are at an increased risk of lactic acidosis which is a serious complication associated with the use of Metformin.
Q. Does Metformin make you feel high?
No, Metformin does not elevate the mood or make you feel high. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise. Rare side effects of Metformin include anxiety and depression.
Q. Can Metformin cause back pain?
Usually, Metformin is not associated with back pain. However, it can be a presentation of stomach upset, a common side effect caused by Metformin which includes bloating (heavy and uncomfortable feeling in the stomach), nausea, vomiting, and diarrhea, or it could be a symptom of lactic acidosis, a rare and a serious complication of Metformin.
Q. Can long-term use of Metformin cause vitamin b12 deficiency?
Yes, Metformin causes vitamin B12 deficiency on long-term use as it interferes with absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can have tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in making balance (ataxia). To avoid these problems, some researchers suggest an intake of vitamin B12 from outside at least once every year.
Q. Is Metformin useful in the management of metabolic syndrome?
Yes, Metformin is seen to be useful in the management of metabolic syndrome, a collection of risk factors that include high blood pressure, high blood sugar levels, abnormal blood cholesterol levels and excess fat around the waist. Metformin is an insulin sensitizer and it improves the action of insulin and normalises blood sugar levels and reduces body weight.
Q. How beneficial is it to take Metformin with glimepiride?
Both Metformin and glimepiride are anti diabetic drugs and can be used together. They work by different mechanisms and can control the blood sugar levels in a much better way when used together as compared to either drug taken alone. However, glimepiride can cause very low blood glucose levels, so a regular monitoring of blood glucose is very important.
Q. Is it safe to take Metformin with cetirizine?
Yes, Metformin can be taken with cetirizine. There are no reported drug interactions or harmful effects when they are used together.
Q. Can I take Metformin and ranitidine together?
Metformin can be taken with ranitidine. However, if you are taking them together, you need to monitor blood glucose levels regularly as ranitidine can decrease the removal of Metformin from the body and increase its blood levels. This can cause very low blood sugar levels and other side effects as well and the dose of Metformin may need adjustment.
Q. How beneficial is it to take Metformin with linagliptin?
Both Metformin and linagliptin are anti-diabetic drugs and can be used together. Their fixed dose combinations are also available and commonly advised once Metformin is unable to control blood sugar levels even after giving the maximum tolerated dose. As they work by different mechanisms, they help in better control of blood sugar levels compared to either drug taken alone.
Q. Does Metformin inhibit hepatitis B virus protein?
Yes, some research studies have shown that Metformin can decrease the multiplication and growth of hepatitis B virus when given along with other antiviral drugs. However, this is indication is still under research and not yet approved.
Q. Can I take Metformin before or after a chest x-ray? Does its use lead to chest x-ray abnormality?
Metformin should be temporarily discontinued before chest or any X-ray that requires injection of a contrast medium or dye. These dyes can decrease kidney function and Metformin along with these dyes can cause a serious side effect like lactic acidosis. So you may need to stop taking Metformin. However, do not stop taking any medicine without talking to your doctor.
Q. Does Metformin make you sleepy?
Metformin can cause sleepiness which could be an early symptom of lactic acidosis along with tiredness, weakness, stomach pain, loose stools, severe muscle pain, muscle cramps and difficulty in breathing. It is a serious condition caused by Metformin seen in old age patients, those with kidney, liver or heart disease, or those who take large amounts of alcohol. If you have these symptoms, stop taking Metformin and consult your doctor.
Q. Does the use of Metformin cause joint pain?
Use of Metformin is not associated with joint pain. However, diabetes itself decreases blood circulation to the joints and even damages them leading to joint pain. Use of anti-diabetic drugs like sitagliptin or saxagliptin is also associated with joint pain. Early symptoms of lactic acidosis like muscle pain and cramps with weakness and tiredness can be mistaken for joint pain.
Q. Can Metformin help in reducing weight gain caused by antipsychotics?
Metformin may be of help in the treatment and prevention of weight gain caused by antipsychotics along with lifestyle modifications like a change in diet and regular exercise. Weight gain is an important reason for discontinuation of these medicines. Metformin improves insulin sensitivity and prevents weight gain, both of these factors are affected by the use of antipsychotics.
Q. How is gliclazide different from Metformin?
Both Metformin and gliclazide are antidiabetic drugs but work in different ways. Metformin works by decreasing glucose production from liver and decreasing glucose absorption from the gut and increasing insulin sensitivity. Gliclazide works by increasing insulin release from the pancreas. Both control blood sugar levels effectively but Metformin causes more of stomach upset, like nausea, vomiting, diarrhea and bloating while gliclazide causes low blood sugar levels and weight gain.
Q. Is Metformin useful in the treatment of fragile X syndrome?
Metformin has shown promising results in some animal research studies in the treatment of fragile X syndrome. It may help in improving mental and behavioral disorders (autism) and control obesity and risk of developing diabetes in these patients. But these results are very preliminary and it is still not approved for the treatment of fragile X syndrome.
Q. What is the difference between liraglutide and Metformin?
Metformin and liraglutide are antidiabetic drugs and both control blood sugar levels effectively. Metformin is taken by oral route and it decreases glucose production from liver and glucose absorption from the gut and increases insulin sensitivity. While liraglutide is an injectable and it increases insulin release from the pancreas. Both cause stomach upset, like nausea, vomiting, diarrhea and bloating while liraglutide also increases the risk of pancreatitis.
Q. Does Metformin use make you feel high?
No, Metformin does not elevate the mood or make you feel high. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise. Rare side effects of Metformin include anxiety and depression.
Q. Does Metformin make you sweat?
Yes, sweating is one of the known side effects of Metformin. The exact cause of this is not known. Some researchers suggest it to be due to low blood sugar levels especially at night which can cause night sweats as well. Monitor your blood sugar levels regularly and talk to your doctor as your dose of Metformin may need to be adjusted.
Q. Can I take Metformin with clomiphene citrate?
Metformin can be taken with clomiphene citrate. They are advised together in patients with infertility along with polycystic ovarian syndrome (PCOS). Clinical studies have shown an improvement in ovulation and pregnancy rates in these patients as compared to use of clomiphene citrate alone or if the patients are resistant to the effects of clomiphene citrate. However, this is still under research.
Q. Is Metformin useful in treating or preventing breast cancer?
Metformin is seen to be useful in the treatment and prevention of cancers especially breast cancer in research studies. As high insulin levels are known to increase the risk of cancer, Metformin decreases cancer cell growth by decreasing insulin and blood glucose levels. However, its use in treating breast cancer is not yet approved.
Q. Does Metformin use increase your chance to get Helicobacter pylori infection?
No, Metformin is not associated with an increased risk of Helicobacter pylori infection. Diabetes itself increases the risk of H.pylori infection which increases the chances of stomach upset like nausea, vomiting, diarrhea, and bloating by Metformin.
Q. Does Metformin use leads to anemia?
Metformin may decrease the levels of vitamin B12 on long term use which may rarely cause a type of anemia in which blood cells are larger than normal (megaloblastic anemia). You may need to take foods rich in vitamin B12 like eggs, dairy products, and meat or a supplement from outside.
Q. Is Metformin useful in the treatment of prediabetes?
Metformin is seen to be useful in the management of prediabetes, a condition with blood glucose levels higher than normal but not high enough to label you as diabetic. Metformin makes the insulin already available in your body to work more effectively, decreases glucose production by liver and increases use of glucose by the muscles and lowers body weight. However, lifestyle modifications like a change in diet and exercise should be tried first as they are seen to be more effective than Metformin.
Q. Can I take Metformin with teneligliptin?
Yes, Metformin can be taken with teneligliptin. It is a good add-on treatment if the blood sugars are very high even after taking Metformin. The risk of low blood sugar levels (hypoglycemia) is also very low with both the medicines. However, consult your doctor before taking them together as a dose adjustment may be needed.
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“The following are the results of on-going survey on 1mg.com for Janumet 50 mg/1000 mg Tablet. These results only indicate the perceptions of the website users. Please base your medical decisions only on the advice of a doctor or a registered medical professional.”
One of the following vendor pharmacies will deliver Janumet 50 mg/1000 mg Tablet: SAT, LHA, AAR, 9T9, NVL, RSA, BLP, OLT, AYU, RSS, KHH, DPP, OHM, OIP, MMS, HBV, AGT, BIO, DFP, SJP, BSN, HIP, STA, JMJ, NWP, DEL, SSA, LCC, ADT, ATL, MPC, OWP, HEX, IPL, PEN, GNC, HGI, BTM, USF, RPP, ATP, PLT, RJH, DYG, SWA, RUS, RHW, EQN, PTS, PNT, BDN, RKS, MAK, SBL, NDP, ZVP, MAX, GTC, ENP, FGH, GPT, SBA, EMB, DLP, MOM, AAY, DDR, SHM, SHP, SAF, GTK, JIV, PSP, WSI
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