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MRP: Rs. 660 for 1 packet(s) (20 ML vial each)
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Composition for IMICRIT

Imipenem(250 mg),Cilastatin(250 mg)

food interaction for IMICRIT

alcohol interaction for IMICRIT

pregnancy interaction for IMICRIT

lactation interaction for IMICRIT

There is no data available. Please consult doctor before consuming the drug.
Interaction with alcohol is unknown. Please consult your doctor.
Imicrit 250mg/250mg injection may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Imicrit 250mg/250mg injection is probably safe to use during breastfeeding. Please consult your doctor.


Imipenem(250 mg)


Imipenem in combination with cilastatin (inhibitor of enzyme dehydropeptidase) is used to treat bacterial infections of lung (pneumonia), urinary tract, abdomen, blood, skin and soft tissue. It is also used to treat infections during or after delivery. It may be used in the management of fever of patients with reduced immunity due to low white blood cells (neutropenia).

How it works

Imipenem belongs to a group of medicines called carbapenem beta-lactam antibiotics. It kills bacteria by inhibiting bacterial cell wall (outer coating of bacteria) formation. As a result, the bacterial cell wall is weakened and ruptures, thereby killing the bacteria.

Common side effects

Decreased urination, Bruise, Bleeding, Chills, Confusion, Convulsion, Diarrhoea, Abdominal pain, Dizziness, Shortness of breath, Fever, Rash, Itching, Sore mouth, Sore throat, Stomach upset, Facial swelling, Wheezing, Vomiting
Cilastatin(250 mg)


Cilastatin is used in combination with imipenem to protect it from an enzyme called dehydropeptidase present in the kidneys in order to increase the antibacterial effect of imipenem. This combination is used in the treatment of complicated intra-abdominal infections, severe pneumonia, intra- and post-partum infections (infections that can occur during and after vaginal and cesarean delivery), complicated urinary tract infections, complicated skin and soft tissue infections, management of neutropenic patients (patients with abnormally few neutrophils in the blood) with fever and in the treatment of patients with bacteraemia (the presence of bacteria in the blood) that occurs in association with, or is suspected to be associated with, any of the infections listed above. 

How it works

Cilastatin is an enzyme inhibitor that belongs to the class of drugs called as renal dehydropeptidase and leukotriene D4 peptidase inhibitors. It inhibits the enzyme dehydropeptidase present in the kidneys which hydrolyses the antibiotic imipenem and thus helps in increasing the levels of imipenem which subsequently increases the antibacterial activity thereby preventing infections.

Common side effects

Vomiting, Nausea, Allergic reaction, Confusion, Diarrhoea, Fever, Rash


No substitutes found

Expert advice for IMICRIT

  • Imipenem is given as a powder for solution for intravenous infusion by a doctor or nurse using a suitable infusion fluid.
  • Do not start or continue the imipenem, if you have kidney, liver, or urinary problems; history of fits (seizures) or central nervous system problems (e.g. tremors).
  • Do not take imipenem if you experience inflammation of the large intestine (colitis) or any other gastrointestinal disease.
  • Do not drive or operate heavy machinery because you may feel sleepy or dizzy while being treated with imipenem.
  • Avoid using imipenem, if you are pregnant, planning to become pregnant or breastfeeding.

Frequently asked questions for IMICRIT


Q. Is imipenem a penicillin or beta lactam drug?
Imipenem is not a penicillin drug. It is a carbapenem beta-lactam antibiotic.
Q. Is imipenem nephrotoxic or cause seizures?
Ganciclovir along with imipenem can increase risk of seizures. Imipenem generally not been shown to cause nephrotoxicity. Please consult your doctor if you experience these side effects.
Q. What is imipenem-cilastatin used for?
Imipenem and cilastatin are used as combination therapy for bacterial infections. Cilastatin reduces the inactivation of imipenem from enzymes released from kidney and extends their spectrum of activity.
Q. What organisms does imipenem cover?
Imipenem is active against most of the gram-positive and gram-negative bacteria, aerobes as well as anaerobes. It is effective against pseudomonas, legionella, and acinetobacter, and many other; not treatable by other antibiotics.


Content on this page was last updated on 15 January, 2014, by Dr. Varun Gupta (MD Pharmacology)