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MRP: Rs. 316.90 for 1 vial(s) (1 injection each)
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Composition for HOLOXAN

Ifosfamide(500 mg)

food interaction for HOLOXAN

alcohol interaction for HOLOXAN

pregnancy interaction for HOLOXAN

lactation interaction for HOLOXAN

It can be taken with or without food, but it is better to take Holoxan 500mg injection at a fixed time.
Holoxan 500mg injection may cause excessive drowsiness and calmness with alcohol.
Holoxan 500mg injection is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Holoxan 500mg injection is probably unsafe to use during breastfeeding. Please consult your doctor.


Ifosfamide(500 mg)


Holoxan 500mg injection is used in combination with other anticancer drugs to treat cancer of the bronchi, breast, testes (male gonads), bladder, head, neck, bone (osteogenic sarcoma), and blood (lymphoma).

How it works

Holoxan 500mg injection belongs to group of medicines called alkylating agents. It inhibits the growth of cancer cells (cytotoxic effects) by interfering with structure and function of DNA that lead to cell death and inhibition of tumor growth.

Common side effects

Inflammation of a vein, Liver injury, Acute renal failure, Urinary bladder inflammation, Bleeding of the urinary bladder, Blood in urine, Bone marrow suppression, Hair loss, Infection, Loss of appetite, Nausea, Renal dysfunction, Vomiting, Reduced blood platelets, Decreased white blood cell count


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Expert advice for HOLOXAN

  • Women should use birth control method to prevent pregnancy while receiving ifosfamide and for 6 months after treatment and men should not father a child during therapy with ifosfamide.
  • You should be regularly undergo kidney function test, urine tests, complete blood cell counts, and other blood tests to monitor progress or to check for side effects while using ifosfamide.
  • Do not drive or operate heavy machinery as ifosfamide may make you feel sleepy or dizzy.
  • Avoid consuming alcohol while taking ifosfamide as it may worsen the side effects.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions for HOLOXAN


Q. Does ifosfamide cause hair loss or a vesicant?
Yes, ifosfamide may cause hair loss and it may act as vesicant.
Q. What is ifosfamide with mesna?
Ifosfamide may cause damage to urinary bladder therefore it is used in combination with mesna to prevent bleeding and inflammation of the urinary bladder (hemorrhagic cystitis).


Content on this page was last updated on 14 June, 2015, by Dr. Varun Gupta (MD Pharmacology)