Holoxan 100mg/2gm Injection

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Zydus Cadila

Composition for Holoxan 100mg/2gm Injection

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Primarily used for

Ifosfamide-induced hemorrhagic cystitis, Blood cancer
Potentiallyunsafewith
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Alcohol
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Lactation
NOT FOR SALE
We do not sell this product at present

Medicine Overview of Holoxan 100mg/2gm Injection

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Uses of Mesna

Mesna is used to prevent ifosfamide-induced hemorrhagic cystitis
It is not for use to reduce the risk of blood in the urine due to other medical conditions.
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Side effects of Mesna

Common

Nausea, Headache, Lightheadedness, Lethargy, Abdominal pain, Flushing (sense of warmth in the face, ears, neck and trunk), Diarrhoea, Rash, Fever, Flu-like symptoms.

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How to use Mesna

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Holoxan 100mg/2gm Injection works

Mesna helps to reduce the risk of inflammation and bleeding in the bladder, who receive ifosfamide (a medicine used to treat cancer).
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Uses of Ifosfamide

Ifosfamide is used in the treatment of blood cancer, breast cancer, non-small cell lung cancer and ovarian cancer.
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Side effects of Ifosfamide

Common

Nausea, Vomiting, Anemia, Hair loss, Decreased white blood cell count, Infection, Blood in urine, Cns toxicity.

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How to use Ifosfamide

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Holoxan 100mg/2gm Injection works

Ifosfamide is an anti-cancer medication. It works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.

In Depth Information on Holoxan 100mg/2gm Injection

Expert advice for Mesna

  • Drink at least 1 litre of fluid daily while you are receiving mesna.
  • Seek immediate medical attention if you experience severe allergic reactions like rash, itching, breathing difficulty, chest tightness, and swelling of the mouth, face, lips, or tongue while taking mesna.
  • Do not drive or operate machinery as mesna may cause drowsiness, dizziness, blurred vision, or light headedness.
  • Tell your doctor if you are pregnant or planning to become pregnant or are breastfeeding.
  • You will be monitored for blood or protein in urine during the treatment of mesna.
  • Do not take if allergic to mesna or any of its ingredients (thiol containing compound)

Expert advice for Ifosfamide

  • Women should use birth control method to prevent pregnancy while receiving ifosfamide and for 6 months after treatment and men should not father a child during therapy with ifosfamide.
  • You should be regularly undergo kidney function test, urine tests, complete blood cell counts, and other blood tests to monitor progress or to check for side effects while using ifosfamide.
  • Do not drive or operate heavy machinery as ifosfamide may make you feel sleepy or dizzy.
  • Avoid consuming alcohol while taking ifosfamide as it may worsen the side effects.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.
Warnings
Special precautions for Holoxan 100mg/2gm Injection
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Alcohol
CAUTION
Holoxan 100mg/2gm Injection may cause excessive drowsiness and calmness with alcohol.
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Pregnancy
WEIGH RISKS VS BENEFITS
Holoxan 100mg/2gm Injection is unsafe to use during pregnancy.

There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
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Lactation
UNSAFE
Holoxan 100mg/2gm Injection is usafe to use during lactation
. Data suggests that the drug may cause toxicity to the baby, or the mother is suffering from a condition in which breast feeding is not advisable.
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Driving
Holoxan 100mg/2gm Injection may cause side effects which could affect your ability to drive.
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Kidney
CAUTION
Holoxan 100mg/2gm Injection should be used with caution in p
atients with kidney disease. Dose adjustment of Holoxan 100mg/2gm Injection may be needed. Please consult your doctor.
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Liver
CAUTION
Holoxan 100mg/2gm Injection should be used with caution in p
atients with liver disease. Dose adjustment of Holoxan 100mg/2gm Injection may be needed. Please consult your doctor.
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Patient Concerns

Frequently asked questions for Holoxan 100mg/2gm Injection

Frequently asked questions for Mesna

Q. Why it is given with ifosamide or cyclophosphamise (Cytoxan)?
It is given along with the chemotherapy drug ifosfamide or cyclophosphamide to reduce the side effects of these drugs
Q. Is mesna compatible with potassium chloride and doxorubicin?
Yes, Mesna is compatible with potassium chloride and doxorubicin
Q. Is Mesna a chemotherapy drug?
Mesna is not a chemotherapy drug
Q. Is Mesna cytotoxic?
No. Mesna is not cytotoxic drug. It is cytoprotective drug
Q. Is Mesna a vesicant?
No, Mesna is not a vesicant.
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Frequently asked questions for Ifosfamide

Q. What is ifosfamide with mesna?
Ifosfamide may cause damage to urinary bladder therefore it is used in combination with mesna to prevent bleeding and inflammation of the urinary bladder (hemorrhagic cystitis).
Q. Does Ifosfamide cause hair loss or a vesicant?
Yes, Ifosfamide may cause hair loss and it may act as vesicant

Substitutes for Holoxan

No substitutes found for this medicine
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