Medicine Overview of Glyree-M Tablet ER
Side Effects of Glyree-M are Hypoglycemia (low blood sugar level), Taste change, Nausea, Diarrhoea, Stomach pain, Headache, Upper respiratory tract infection.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Glyree-M 2 Forte Tablet is to be taken with food.
Glyree-M 2 Forte Tablet may cause stomach upset if taken empty stomach.
Glyree-M 2 Forte Tablet is a combination of two antidiabetic medicines: Glimepiride and Metformin. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide which works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin.
In Depth Information on Glyree-M Tablet ER
Glyree-M Tablet ER related warnings
Taking metformin with alcohol can cause lactic acidosis and you may experience malaise, respiratory distress, slow or irregular heartbeat, sleepiness, stomach upset, or other unusual symptoms.
WEIGH RISKS VS BENEFITS
Glyree-M 2 Forte Tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Glyree-M 2 Forte Tablet is probably safe to use during lactation.
Limited human data suggests that the drug does not represent a significant risk to the baby.
Your ability to drive may be affected if your blood sugar is low or high. If this happens, do not drive.
Glyree-M 2 Forte Tablet should be used with caution in patients with kidney disease. Dose adjustment of Glyree-M 2 Forte Tablet may be needed. Please consult your doctor.
Use of Glyree-M 2 Forte Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Glyree-M 2 Forte Tablet should be used with caution in patients with liver disease. Dose adjustment of Glyree-M 2 Forte Tablet may be needed. Please consult your doctor.
Glyree-M 2 Forte Tablet is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.
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Frequently asked questions about Glyree-M Tablet ER
Yes, Glyree-m does expire. Please check the expiry date written on the pack of this medicine. Do not use Glyree-m after the expiry date.
Q. Can the use of Glyree-m lead to lactic acidosis?
Yes, the use of Glyree-m can lead to lactic acidosis. It is a medical emergency which is caused by increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect associated with the use of metformin and therefore, it is contraindicated in patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Glyree-m and immediately consult your doctor.
Glyree-m is a combination of two medicines: Glimepiride+Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM) along with diet and exercise to improve blood glucose levels in adults. Glimepiride lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of Type 1 DM.
Q. What are the possible side effects of Glyree-m?
The use of Glyree-m is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious, but rare side effect lactic acidosis. On long term use it can also lead to Vitamin B12 deficiency.
Q. Can the use of Glyree-m lead to Vitamin B12 deficiency?
Yes, the use of Glyree-m can cause vitamin B12 deficiency on long-term use as it interferes with absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can have tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in making balance (ataxia). To avoid such problems, some researchers suggest an intake of vitamin B12 from outside at least once every year.
Q. Can the use of Glyree-m cause hypoglycemia?
Yes, the use of Glyree-m can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, do more than routine exercise or take other antidiabetic medicine along with. So, regular monitoring of blood sugar level is important. Always keep a quick source of sugar like glucose tablets, honey or fruit juice with you.
Q. Is it safe to take alcohol while I am also taking Glyree-m?
No, it is not safe to take Glyree-m along with alcohol, as it may lower your low blood sugar levels (hypoglycemia) and can increase the chances of lactic acidosis.
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