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Composition for ENTACOM PLUS


food interaction for ENTACOM PLUS

alcohol interaction for ENTACOM PLUS

pregnancy interaction for ENTACOM PLUS

lactation interaction for ENTACOM PLUS

Avoid Entacom plus 100mg/25mg/200mg tablet with high protein meals such as cottage cheese, Swiss cheese, protein powder, eggs and milk.
Entacom plus 100mg/25mg/200mg tablet may cause excessive drowsiness and calmness with alcohol.
Entacom plus 100mg/25mg/200mg tablet may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Entacom plus 100mg/25mg/200mg tablet is probably unsafe to use during breastfeeding. Please consult your doctor.




Levodopa is used to treat symptoms such as stiffness, tremors, spasms, and poor muscle control associated with Parkinson disease and parkinsonism-like symptoms caused by taking certain other drugs such as chlorpromazine, fluphenazine, perphenazine.

How it works

Levodopa is a pro-drug and crosses blood-brain barrier where it is converted into a chemical (dopamine) in the body which is required by the brain for proper functioning and relieves symptoms associated with Parkinson's disease.

Common side effects

Vomiting, Nausea, Nervousness, Memory impairment, Confusion, Constipation, Diarrhoea, Dizziness, Dry mouth, Headache, Insomnia, Loss of appetite, Mood changes, Uncoordinated body movements, Nightmare


Carbidopa is used in combination with levodopa to treat symptoms associated with Parkinson disease and parkinsonism-like symptoms caused by other conditions. 

How it works

Carbidopa works by preventing the breakdown of levodopa in the bloodstream. This allows more levodopa to enter the brain, where it can decrease Parkinson's symptoms.

Common side effects

Nausea, Neuroleptic malignant syndrome, Panic attacks, Altered behaviour, Mood changes, Altered sleep, Burning sensation of tongue, Confusion, Convulsion, Dizziness, Drowsiness, Fever, Frequent dreams, Hallucination, Increased sweating, Tachycardia, Heart rate irregular, Tremor, Vomiting, Worsening of tremor, Muscle stiffness


Entacapone is used in the treatment of Parkinson’s disease in combination with levodopa and carbidopa.

How it works

Entacapone belongs to the class of drugs known as COMT (catechol-O-methyltransferase) inhibitors. Entacapone works by increasing the levels of levodopa and carbidopa in the brain, thereby helping to relieve the symptoms of Parkinson’s disease.

Common side effects

Confusion, Dizziness, Diarrhoea, Drowsiness, Shortness of breath, Fever, Hallucination, Muscle stiffness, Stomach pain


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Expert advice for ENTACOM PLUS

  • If you are taking carbidopa with levodopa, do not take iron salts (eg, ferrous sulfate), within 2 hours before or a diet that is high in protein.
  • Avoid vitamin products that contain vitamin B6 (pyridoxine). This vitamin may reduce the effectiveness of levodopa.
  • Do not use levodopa, if you are allergic to levodopa or any other ingredient.
  • Do not use levodopa, if you have narrow-angle glaucoma; if you are suffering from malignant melanoma (a type of cancer); skin cancer or you have any unusual moles; severe mental disorder.
  • Do not take levodopa, if you have a history of fits (convulsions); heart problems or blood pressure problems; asthma or other lung problems; liver or kidney problems; blood or hormone (endocrine) problems; depression or any other psychiatric disorder; ulcer in your gut or have vomited blood or stomach or intestinal bleeding.
  • If you are undergoing any tests for urine glucose or urine ketones, levodopa may cause the results of some tests to be wrong.
  • Levodopa may cause drowsiness, dizziness, light-headedness or sudden sleep. Do not drive or use machinery while using it.
  • Do not take alcohol along with levodopa.

Frequently asked questions for ENTACOM PLUS


Q. Is levodopa a controlled substance/ a narcotic/ addictive/ lipid soluble/ a dopamine agonist/ a prodrug/ a monoamine oxidase inhibitor (MAOI)/ toxic/ an anticholinergic?
Levopoda is a lipid soluble prodrug that gets converted into dopamine when it crosses the blood brain barrier. It is not a dopamine agonist, controlled substance, narcotic, MAOI, toxic or anticholinergic. It may cause addiction in some patients.
Q. Does levodopa work/ stop tremors?
Levodopa is used to treat the symptoms of Parkinson's disease which includes tremors (shaking), stiffness, and slowness of movement. It works in most patients if taken at recommended dosage and duration.
Q. Does levodopa cause dyskinesia/ dementia/ accelerate Parkinson's disease/ get you high/stop cause constipation/ urine discoloration?
Levopoda may cause side effects such as constipation, a feeling of high in some patients.
Q. Does levodopa help with balance?
As levodopa helps in controlling tremors,it can improve balancing in patients.


Q. What is carbidopa used for/ what does carbidopa treat/ Is carbidopa a dopamine agonist/ a monoamine oxidase inhibitor (MAOI)/ addictive/ a blood thinner?
Carbidopa is used in combination with other drug levodopa to treat symptoms associated with Parkinson disease and parkinsonism-like symptoms caused by other conditions. It is neither a dopamine agonist, nor a MAOI. It can be addictive and cause blood thinning in some patients.

Q. Is carbidopa levodopa/ Is carbidopa levodopa a controlled substance/ a MAOI/ a narcotic/ is carbidopa-levodopa addiction?
Carbidopa works by helping levodopa to reach the brain. It is not a controlled substance, a MAOI, a narcotic. Some people may get addicted to carbidopa levodopa treatment for experiencing better sense of well-being.

Q. How does carbidopa effect levodopa?
Carbidopa prevents conversion of levodopa to dopamine in the bloodstream, providing a larger amount of levodopa to relieve symptoms of Parkinson's disease.

Q. Does carbidopa get you high/lower blood pressure/cause hallucinations/cause constipation?
Carbidopa can get some people high, it can cause side effects such as low blood pressure, hallucinations and constipation.

Q. Does carbidopa cross the blood brain barrier?
Carbidopa itself cannot cross the blood brain barrier but it allows peripheral levodopa in doing so.

Q. How does carbidopa affect the on-off phenomenon?
Patients treated with levodopa therapy for Parkinson's disease may develop motor fluctuations characterized by end-of-dose failure, peak dose dyskinesia, and akinesia. The advanced form of motor fluctuations ('on-off’ phenomenon) is characterized by unpredictable swings from mobility to immobility. Although the causes of the motor fluctuations are not completely understood, in some patients they may be attenuated by treatment regimens that produce steady plasma levels of levodopa.

Q. What does carbidopa levodopa look like?
Carbidopa levopoda is basically available in circular, oval or elliptical form and in different colors and sizes which varies for different brands.


Q. Is entacapone a dopamine agonist? 
No, entacapone is not a dopamine agonist.
Q. Is entacapone a controlled substance?
Yes, entacapone is a controlled substance and may not be available OTC.
Q. Does entacapone cross the bbb?
No, entacapone does not cross the blood brain barrier.
Q. Does entacapone lower blood pressure?
No, entacapone does not lower blood pressure.

Top Medicines Prescribed with ENTACOM PLUS 100MG/25MG/200MG TABLET


Content on this page was last updated on 09 August, 2016, by Dr. Varun Gupta (MD Pharmacology)