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MRP: Rs. 54.90 for 1 vial(s) (2 ML injection each)
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Composition for ENDOXAN-N

Cyclophosphamide(200 mg)

food interaction for ENDOXAN-N

alcohol interaction for ENDOXAN-N

pregnancy interaction for ENDOXAN-N

lactation interaction for ENDOXAN-N

It is better to take Endoxan-n 200 mg injection empty stomach (1 hour before food or 2 hours after food).
Interaction with alcohol is unknown. Please consult your doctor.
Endoxan-n 200 mg injection is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Endoxan-n 200 mg injection is probably unsafe to use during breastfeeding. Please consult your doctor.


Cyclophosphamide(200 mg)


Endoxan-n 200 mg injection is used alone or in combination with other medications for the treatment of various cancers including – cancers related to the immune system (lymphomas), cancers of the white blood cells (leukemia), cancer of the bone and bone marrow (myeloma, osteogenic sarcoma), breast cancer, lung cancer, cancer of the eye (retinoblastoma) and cancers of brain cell in children (eg. Neuroblastoma). It may also be used to treat disease caused due to kidney damage (nephrotic syndrome) in children. It is also used to treat certain autoimmune disorders (serious disorders of the immune system affecting various parts of the body).

How it works

Endoxan-n 200 mg injection is an anti-cancer drug that belongs to the class of medicines called alkylating agents. It works by interfering with normal DNA synthesis thereby slowing down or stopping growth and multiplication of cancer cells. It also suppresses the activity of the body’s immune system (immunosuppressant) thereby offering treatment for disorders involving the immune system (e.g. nephrotic syndrome, autoimmune disorders).

Common side effects

Vomiting, Nausea, Abnormal liver function tests, Absence of menstrual periods, Blood in urine, Changes in skin color, Diarrhoea, Hair loss, Headache, Decreased white blood cell count, Loss of appetite, Nail disorder, Renal dysfunction, Stomach pain, Stomach upset


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Expert advice for ENDOXAN-N

  • Monitor your blood counts with the help of regular blood tests while on treatment with cyclophosphamide.
  • Contact your doctor immediately if you experience difficulty in urinating, blood in urine or any other bladder/ kidney related problems while on treatment with cyclophosphamide.
  • Do not start treatment with cyclophosphamide if you are planning to receive any vaccine or if you have a surgery scheduled or you have had a surgical removal of the adrenal glands.
  • Take precautions as treatment with cyclophosphamide severely affects your immune system, increasing susceptibility to infections (e.g. pneumonia).
  • Caution must be exercised during use of cyclophosphamide in very ill patients, patients with kidney/liver disorders, lung problems and heart problems (related to QT prolongation and abnormal heartbeats).

Frequently asked questions for ENDOXAN-N



Q. Is cyclophosphamide a cytotoxic drug?
Yes. Cyclophosphamide is chemotherapy and a cytotoxic drug used in the treatment of various cancers.

Q. Is cyclophosphamide chemotherapy?
 It is toxic to cancer cells and interferes with the cell’s DNA synthesis, thus slowing down or stopping its growth and multiplication (cytotoxic effect).
Q. Is cyclophosphamide an antimetabolite/ steroid/ anthracycline?
No. Cyclophosphamide is an alkylating agent used in the treatment of various cancers. It is not an antimetabolite or anthracycline type of anti-cancer drug. It has a structure and effects different from steroids. 
Q. Is cyclophosphamide prodrug?
Yes. Cyclophosphamide is administered in the inactive form (prodrug) and gets converted to active form which has anti-cancer properties.
Q. Is cyclophosphamide a vesicant?
Cyclophosphamide is an irritant and can cause tissue inflammation at site of injection if its oozes out of the vein. 
Q. Does cyclophosphamide have a boxed warning?
No. Cyclophosphamide does not have any specific boxed warning. Please discuss with your doctor about all the possible side effects and warnings relating to use of cyclophosphamide.
Q. Does cyclophosphamide cause hair loss/ infertility/ thrombocytopenia/ headaches/ hemorrhagic cystitis?
Yes. Hair loss (alopecia), infertility (in men and women), low platelet count (thrombocytopenia), headaches and inflammation of the urinary bladder (hemorrhagic cystitis) are among the known common side effects of cyclophosphamide use.
Q. Does cyclophosphamide come in liquid form?
No. Cyclophosphamide comes in a dry powder form that be reconstituted to make a solution for injection or oral liquid as directed. 
Q. Is cyclophosphamide removed by plasma exchange?
Cyclophosphamide is unlikely to be removed by plasma exchange since a very low percentage of drug is bound to proteins in the plasma.


Content on this page was last updated on 30 October, 2014, by Dr. Varun Gupta (MD Pharmacology)