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ENDOXAN ASTA 1000 MG INJECTION

Injection
MRP: Rs. 158.73 for 1 vial(s) (1 injection each)
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Composition for ENDOXAN

Cyclophosphamide(1000 mg)

food interaction for ENDOXAN

alcohol interaction for ENDOXAN

pregnancy interaction for ENDOXAN

lactation interaction for ENDOXAN

food
alcohol
pregnancy
lactation
It is better to take Endoxan asta 1000 mg injection empty stomach (1 hour before food or 2 hours after food).
Interaction with alcohol is unknown. Please consult your doctor.
Endoxan asta 1000 mg injection is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
WEIGH RISKS VS. BENEFITS
Endoxan asta 1000 mg injection is probably unsafe to use during breastfeeding. Please consult your doctor.
UNSAFE

SALT INFORMATION for ENDOXAN

Cyclophosphamide(1000 mg)

Uses

Endoxan asta 1000 mg injection is used in the treatment of ovarian cancer, breast cancer, non-small cell lung cancer and blood cancer.

How it works

Endoxan asta 1000 mg injection is an anti-cancer drug that belongs to the class of medicines called alkylating agents. It works by interfering with normal DNA synthesis thereby slowing down or stopping growth and multiplication of cancer cells. It also suppresses the activity of the body’s immune system (immunosuppressant) thereby offering treatment for disorders involving the immune system (e.g. nephrotic syndrome, autoimmune disorders).

Common side effects

Vomiting, Nausea, Abnormal liver function tests, Absence of menstrual periods, Blood in urine, Changes in skin color, Diarrhoea, Hair loss, Headache, Decreased white blood cell count, Loss of appetite, Nail disorder, Renal dysfunction, Stomach pain, Stomach upset

SUBSTITUTES for ENDOXAN

4 Substitutes
Sorted By
RelevancePrice
  • CYCLOXAN 1000MG INJECTION
    (1 injection in vial)
    Biochem Pharmaceutical Industries
    Rs. 144/injection
    Injection
    Rs. 144
    save 9% more per injection
  • CYCLOCEL 1000MG INJECTION
    (1 injection in vial)
    Celon Laboratories Ltd
    Rs. 113.38/injection
    Injection
    Rs. 113.38
    save 29% more per injection
  • PHOSMID 1000MG INJECTION
    (1 injection in vial)
    Neon Laboratories Ltd
    Rs. 79/injection
    Injection
    Rs. 79
    save 50% more per injection
  • UNIPHOS 1000MG INJECTION
    (1 injection in vial)
    United Biotech Pvt Ltd
    Rs. 107.30/injection
    Injection
    Rs. 107.30
    save 32% more per injection

Expert advice for ENDOXAN

  • Monitor your blood counts with the help of regular blood tests while on treatment with cyclophosphamide.
  • Contact your doctor immediately if you experience difficulty in urinating, blood in urine or any other bladder/ kidney related problems while on treatment with cyclophosphamide.
  • Do not start treatment with cyclophosphamide if you are planning to receive any vaccine or if you have a surgery scheduled or you have had a surgical removal of the adrenal glands.
  • Take precautions as treatment with cyclophosphamide severely affects your immune system, increasing susceptibility to infections (e.g. pneumonia).
  • Caution must be exercised during use of cyclophosphamide in very ill patients, patients with kidney/liver disorders, lung problems and heart problems (related to QT prolongation and abnormal heartbeats).

Frequently asked questions for ENDOXAN

Cyclophosphamide

Q.Is cyclophosphamide a cytotoxic drug?
Yes. Cyclophosphamide is chemotherapy and a cytotoxic drug used in the treatment of various cancers

Q.Is cyclophosphamide chemotherapy?
It is toxic to cancer cells and interferes with the cell's DNA synthesis, thus slowing down or stopping its growth and multiplication (cytotoxic effect)

Q.Is cyclophosphamide an antimetabolite/ steroid/ anthracycline?
No. Cyclophosphamide is an alkylating agent used in the treatment of various cancers. It is not an antimetabolite or anthracycline type of anti-cancer drug. It has a structure and effects different from steroids

Q.Is cyclophosphamide prodrug?
Yes. Cyclophosphamide is administered in the inactive form (prodrug) and gets converted to active form which has anti-cancer properties

Q.Is cyclophosphamide a vesicant?
Cyclophosphamide is an irritant and can cause tissue inflammation at site of injection if its oozes out of the vein

Q.Does cyclophosphamide have a boxed warning?
No. Cyclophosphamide does not have any specific boxed warning. Please discuss with your doctor about all the possible side effects and warnings relating to use of cyclophosphamide

Q.Does cyclophosphamide cause hair loss/ infertility/ thrombocytopenia/ headaches/ hemorrhagic cystitis?
Yes. Hair loss (alopecia), infertility (in men and women), low platelet count (thrombocytopenia), headaches and inflammation of the urinary bladder (hemorrhagic cystitis) are among the known common side effects of cyclophosphamide use

Q.Does cyclophosphamide come in liquid form?
No. Cyclophosphamide comes in a dry powder form that be reconstituted to make a solution for injection or oral liquid as directed

Q.Is cyclophosphamide removed by plasma exchange?
Cyclophosphamide is unlikely to be removed by plasma exchange since a very low percentage of drug is bound to proteins in the plasma.

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Content on this page was last updated on 23 February, 2014, by Dr. Varun Gupta (MD Pharmacology)