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ENDOXAN 500 MG TABLET
Prescription Required
Product introduction
ENDOXAN 500 MG TABLET is used in the treatment of different kinds of cancers. It is also used to treat kidney disease known as nephrotic syndrome in children after other treatments have not worked. It may be also used to treat other conditions, as determined by the doctor.
ENDOXAN 500 MG TABLET should be taken with food preferably in morning but at the same time every day to get the most benefit. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include vomiting, nausea, hair loss, fever, and blood in urine. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver or kidneys. Your doctor will advise you regular blood tests to check for these. It is advised that you drink extra fluids so that you pass more urine. This will help prevent bladder and kidney problems and keep your kidneys working well.
Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
ENDOXAN 500 MG TABLET should be taken with food preferably in morning but at the same time every day to get the most benefit. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include vomiting, nausea, hair loss, fever, and blood in urine. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver or kidneys. Your doctor will advise you regular blood tests to check for these. It is advised that you drink extra fluids so that you pass more urine. This will help prevent bladder and kidney problems and keep your kidneys working well.
Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Endoxan Tablet
Benefits of Endoxan Tablet
In Cancer
ENDOXAN 500 MG TABLET helps to treat certain kinds of cancer. It may be used alone or in combination with other medicines to treat cancer in various parts of the body. ENDOXAN 500 MG TABLET kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
In Nephrotic syndrome
Nephrotic syndrome is a kidney disorder that causes your body to pass too much protein in your urine accompanied with excessive swelling over various parts of the body such as around the eyes and in the feet and ankles. ENDOXAN 500 MG TABLET works by suppressing the immune system thereby reducing inflammation and swelling that occur in nephrotic syndrome. It reduces the protein in the urine and also helps in getting rid of the extra fluid, thereby relieving the swelling over different parts of the body. This helps to restore the normal kidney function and prevents further damage to the kidneys.
Side effects of Endoxan Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Endoxan
- Vomiting
- Nausea
- Hair loss
- Fever
- Blood in urine
- Diarrhea
- Decreased white blood cell count (neutrophils)
How to use Endoxan Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. ENDOXAN 500 MG TABLET is to be taken with food.
How Endoxan Tablet works
ENDOXAN 500 MG TABLET is an anti-cancer medication. It is an alkylating agent which works by damaging the genetic material (DNA and RNA) of the cancer cells, thereby stopping their growth and multiplication. This is how it works against cancer.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with ENDOXAN 500 MG TABLET.
Pregnancy
CONSULT YOUR DOCTOR
ENDOXAN 500 MG TABLET is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
UNSAFE
ENDOXAN 500 MG TABLET is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
ENDOXAN 500 MG TABLET may cause side effects which could affect your ability to drive.
ENDOXAN 500 MG TABLET may cause undesirable effects (e.g., dizziness, blurred vision, visual impairment) which could affect the ability to drive.
ENDOXAN 500 MG TABLET may cause undesirable effects (e.g., dizziness, blurred vision, visual impairment) which could affect the ability to drive.
Kidney
CAUTION
ENDOXAN 500 MG TABLET should be used with caution in patients with severe kidney disease. Dose adjustment of ENDOXAN 500 MG TABLET may be needed. Please consult your doctor.
Liver
CAUTION
ENDOXAN 500 MG TABLET should be used with caution in patients with liver disease. Dose adjustment of ENDOXAN 500 MG TABLET may be needed. Please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- ENDOXAN 500 MG TABLET helps in the treatment of cancer.
- Drink plenty of fluids or urinate frequently to prevent urinary problems while taking this medication.
- Take it with food if you experience irritation of the stomach, preferably in the morning.
- Your doctor may get regular blood tests to monitor your blood counts while on treatment with this medication.
- You are more likely to get sick or heal slower while taking this medication. Talk to your doctor before getting any vaccines.
- Contact your doctor immediately if you experience difficulty in urinating or blood in urine while on treatment with this medication.
- Do not take ENDOXAN 500 MG TABLET if you are pregnant or breastfeeding.
- Use effective contraception method to prevent pregnancy while taking this medicine.
Fact Box
Chemical Class
Nitrogen Mustard Compounds
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Alkylating agent
Interaction with drugs
Taking Endoxan with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Clowil, Odis, Kamestin
Serious
Brand(s): Cardisip, Digover, Caxin
Serious
Brand(s): Equirab, Carig, Zyrig
Serious
Brand(s): Geoflu
Serious
Patient concerns
User feedback
Patients taking ENDOXAN 500 MG TABLET
Once A Day
64%
Once A Week
29%
Once A Month
7%
What are you using Endoxan Tablet for?
Cancer
67%
Nephrotic syn*
33%
*Nephrotic syndrome
FAQs
Q. Can ENDOXAN 500 MG TABLET cause infertility?
Yes, ENDOXAN 500 MG TABLET can cause infertility in both men and women. It may interfere with the normal menstrual cycle in women and may stop sperm production in men. If you are considering becoming parents after the treatment please discuss this with your doctor. Talk to your doctor about cryopreservation (freezing) of sperm or eggs prior to treatment because of the possibility of irreversible infertility due to therapy with ENDOXAN 500 MG TABLET.
Q. Do I need to avoid sun exposure during treatment with ENDOXAN 500 MG TABLET?
No, there is no evidence that you need to avoid sun exposure while on ENDOXAN 500 MG TABLET. Skin and nail discoloration are reported rarely with ENDOXAN 500 MG TABLET.
Q. Can ENDOXAN 500 MG TABLET cause cancer?
Cancer medicines and radiation therapy can increase the risk of developing other cancers. These may not develop soon and may take a number of years after the completion of your treatment. The risk of developing cancer with ENDOXAN 500 MG TABLET is high in the urinary bladder. Other rare cancers that may occur with use of ENDOXAN 500 MG TABLET include Acute leukemia, Myelodysplastic syndrome, and cancer of the ureters.
Q. Is ENDOXAN 500 MG TABLET chemotherapy medicine?
Yes, ENDOXAN 500 MG TABLET is a chemotherapy medicine, it belongs to the class of alkylating agents. It works by killing cancer cells. It is also known as cytotoxic medicine.
Q. Can ENDOXAN 500 MG TABLET be used for non-cancer condition?
Yes, ENDOXAN 500 MG TABLET can be used to treat nephrotic syndrome (a disease that is caused by damage to the kidneys) in children whose disease has not improved, has gotten worse, or has come back after taking other medications. Along with that, it can be used in children who experienced intolerable side effects with other medications. However, in adults, the safety and effectiveness of ENDOXAN 500 MG TABLET for nephrotic syndrome has not been established.
Q. Can ENDOXAN 500 MG TABLET causes weight loss?
Yes, ENDOXAN 500 MG TABLET may cause weight loss because of reduced appetite. This reduction in weight could be due to underlying cancer. Consult your doctor, if weight loss is worrying you.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 975.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 335-38.
- Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 26 Mar. 2019] (online) Available from:
- Cyclophosphamide monohydrate. Norfolk, UK: Baxter Healthcare Ltd.; 2004 [revised 9 Dec. 2016]. [Accessed 26 Mar. 2019] (online) Available from:
Marketer details
Name: Zydus Cadila
Address: Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Country of origin: India
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DISCONTINUED
We do not facilitate sale of this product at present