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food interaction for D-COF

alcohol interaction for D-COF

pregnancy interaction for D-COF

lactation interaction for D-COF

Avoid D-cof syrup with caffeine and chocolate as well as food containing caffeine and chocolate such as tea leaves, cocoa beans.
D-cof syrup may cause excessive drowsiness and calmness with alcohol.
Taking phenylpropanolamine with alcohol can increase the risk of cardiovascular side effects such as increased heart rate, chest pain, or blood pressure changes.
D-cof syrup may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.




Phenylpropanolamine is used to relieve blocked nose or sinuses caused by common cold and seasonal nasal allergies (hay fever). It is also used to decrease appetite for weight control.

How it works

Phenylpropanolamine belongs to a class of medications called nasal decongestants. It stimulates receptors on blood vessels in the nose and sinuses leading to its constriction and reduction in blood flow thereby relieving congestion.

Common side effects

Nausea, Palpitations, Psychosis, Chest tightness, Dizziness, Epileptic convulsion, Hallucination, Headache, Increased blood pressure, Tremor


Chlorpheniramine is used to relieve symptoms of  runny nose, sneezing, itching, and watery eyes caused by allergies, the common cold, or the flu and allergies due to food and insect bites and hay fever.

How it works

Chlorpheniramine belongs to class of medications called antihistamines. It acts by blocking a natural chemical (histamine) that your body makes during an allergic reaction. Histamine is responsible for many symptoms of allergy. 

Common side effects

Nausea, Constipation, Drowsiness, Dry mouth, Dry throat, Dry skin, Headache, Inability to empty the urinary bladder, Loss of appetite, Nasal congestion, Chest congestion, Vomiting


Dextromethorphan is used to suppress dry coughs (coughs that do not produce phlegm or mucus).

How it works

Dextromethorphan belongs to class of drugs called antitussives. It works by decreasing activity in the part of the brain that causes coughing.

Common side effects

Nausea, Nervousness, Drowsiness, Dizziness, Lightheadedness, Restlessness, Stomach pain, Vomiting


No substitutes found

Expert advice for D-COF

  • Do not continue phenylpropanolamine for more than 7 days if your condition does not improve or if you have high fever.
  • Tell your doctor if you have high blood pressure, heart problems, liver or kidney disease, diabetes, prostate enlargement or visual problems due to increased pressure in the eyes (glaucoma).
  • Seek immediate medical attention and discontinue medication if you experience difficulty in breathing, sudden swelling or skin reactions, fits, rapid heartbeat or hallucinations.
  • Use with caution if you are a woman or an elderly patient. Woman may be at a higher risk of haemorrhagic stroke (bleeding in the brain).
  • Avoid driving or operating machinery if you feel dizzy or drowsy after taking phenylpropanolamine.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.
  • Do not take if allergic to phenylpropanolamine or any of its ingredients.

Frequently asked questions for D-COF


Q. Is phenylpropanolamine a controlled substance?
Phenylpropanolamine is a controlled substance since it can be used for manufacturing of illegal drugs.

Q. Is phenylpropanolamine the same as phenylephrine?
Phenylpropanolamine and phenylephrine are different drugs belonging to the same class of medications (nasal decongestants). Both are used to relieve blocked nose or sinuses caused by common cold and seasonal nasal allergies (hay fever).

Q. Is phenylpropanolamine still on the market?
Phenylpropanolamine is banned in India due to increased risk of haemorrhagic stroke (bleeding in the brain) and is no longer marketed in India.

Q. Does phenylpropanolamine cause stroke?
Phenylpropanolamine has shown to increase the risk of hemorrhagic stroke (bleeding in the brain). Women are at a higher risk.


Q. Does chlorpheniramine or chlorpheniramine maleate cause increase in blood pressure/ drowsy/non drowsy/sedating/get you high/keep you awake/sleepiness/make you tired/weight gain?
Chlorpheniramine causing these side effects is common or rare. Always consult your doctor, if you experience any of these side effects.
Q. Is chlorpheniramine like Benadryl?
No, chlorpheniramine is different from Benadryl.
Q. Is chlorpheniramine prescription?
Yes, it is available with doctor’s prescription only.
Q.Can I take chlorpheniramine or chlorpheniramine maleate with Panadol/ cetirizine /Zyrtec/ Allegra/ warfarin/ diphenhydramine/ ibuprofen/Claritin/guaifenesin/Benadryl?
Yes, but taking other medicines may alter the effects of chlorpheniramine. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required.
Q. Does chlorpheniramine contain aspirin?
No, it does not contain aspirin in it. Chlorpheniramine is a different drug than aspirin.


Q. Is dextromethorphan a steroid/an opiate/an antihistamine/ a narcotic/an NSAID/a controlled substance/contain alcohol/have codeine?
Dextromethorphan is a decongestant and not a steroid, antihistamine, opiate, NSAID or narcotic, but can have addictive effects if taken at large doses than recommended. It does not contain codeine or alcohol. It is not a controlled substance.
Q. Does dextromethorphan work/ how much dextromethorphan can i take for cough?
Dextromethorphan works for most of the patient. It should be taken in amounts exactly as directed on the label, or as prescribed by your doctor. Cough medicine is usually taken only for a short time until your symptoms clear up. Do not use the medication in larger amounts, or use it for longer than recommended.
Q.  Is dextromethorphan safe/ does dextromethorphan makes you sleepy/make you tired/ raise blood sugar? 
Dextromethorphan causes mild sedation effect thus can make you feel sleepy. It does not raise blood sugar or make you tired. Dextromethorphan is generally safe if taken at recommended doses and duration. 
Q. Can i take dextromethorphan with high blood pressure/ safe for high blood pressure/ raise blood pressure/ thin blood?
Though it isn’t reported, but it should be used carefully in people with high blood pressure, as dextromethorphan may cause high blood pressure and the effectiveness of dextromethorphan is decreased by high blood pressure medications. 
Q. Can I take dextromethorphan with benzonatate/acetaminophen/codeine/ibuprofen/ diphenhydramine/pseudoephedrine/guaifenesin/Tamiflu/Benadryl?
Drug interaction with any of the above mentioned drugs is not documented, but it can occur. Always follow your doctor’s advice before taking any medicine with dextromethorphan.


Content on this page was last updated on 12 July, 2015, by Dr. Varun Gupta (MD Pharmacology)