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Composition for COXVAL-MR

Valdecoxib(10 mg),Tizanidine(2 mg)

food interaction for COXVAL-MR

alcohol interaction for COXVAL-MR

pregnancy interaction for COXVAL-MR

lactation interaction for COXVAL-MR

There is no data available. Please consult doctor before consuming the drug.
Coxval-mr 10mg/2mg tablet mr may cause excessive drowsiness and calmness with alcohol.
Coxval-mr 10mg/2mg tablet mr may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Coxval-mr 10mg/2mg tablet mr is probably unsafe to use during breastfeeding. Please consult your doctor.


Valdecoxib(10 mg)


Valdecoxib is used in adults to treat pain and inflammation caused due to osteoarthritis (pain, swelling, and reduced motion in joints) and rheumatoid arthritis (inflammatory disorder that typically affects the small joints in hands and feet). It is also used to treat menstrual pain.

How it works

Valdecoxib belongs to the class of drugs known as non-steroidal anti-inflammatory agents. Valdecoxib works by reducing the production of chemical (prostaglandin) in the body, which is responsible for inducing pain and inflammation.

Common side effects

Belching, Cough, Diarrhoea, Ear congestion, Headache, Heartburn, Indigestion, Sore throat
Tizanidine(2 mg)


Tizanidine is used to treat rigidity of muscles (spasticity) associated with various brain and nerve disorders (like cerebral palsy, meningitis, multiple sclerosis, motor neuron disease, cerebrovascular accidents), diseases of the spinal cord, other injuries which affect the brain and other parts of nervous system in adults.

How it works

Tizanidine belongs to group of medicines called centrally acting muscle relaxants. It acts by blocking the nerve impulses which excites the muscles reducing their tone. As a result, the muscle relaxes and there is reduction of pain and spasms.

Common side effects

Vomiting, Nausea, Abdominal pain, Skin rash, Allergic reaction, Altered vision, Back pain, Bruise, Bleeding, Dizziness, Depression, Drowsiness, Nervousness, Dry mouth, Fatigue, Heartburn, Altered heart rate, Bradycardia, Increased sweating, Influenza like symptoms, Loss of appetite, Muscle cramp, Tingling sensation, Auditory hallucination, Visual hallucination, Weakness, Yellow discoloration of skin, Yellow discoloration of eye, Constipation, Diarrhoea


No substitutes found

Expert advice for COXVAL-MR

  • Before you take valdecoxib, inform your doctor if you suffer from liver and or kidney problems. 
  • Do not take valdecoxib if you have experienced asthma, hives or any allergic reaction after taking a sulfabased medication.
  • Stop taking valdecoxib and contact your doctor immediately if you develop a skin rash, hives, itching, difficulty breathing, swelling of the lips, tongue or face, or other symptoms of an allergic reaction.
  • Caution should be exercised while using valdecoxib as an increased risk of cardiovascular events (including heart attack and stroke) have been reported with its use.
  • Overdose of valdecoxib may cause dizziness; it is advisable to avoid driving or operating heavy machinery under such circumstances.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions for COXVAL-MR


Q. What is valdecoxib tablet and what are they used for? 
Valdecoxib tablets are pain killer tablets used in treating the pain and inflammation caused by arthritis and for painful menstruation.
Q. Why is valdecoxib banned?
Valdecoxib was banned due to safety concerns of an increased risk of cardiovascular events and serious and potentially life-threatening skin reactions.


Q. Does tizanidine contain sulfa or asprin?
Tizanidine does not contain sulfa and aspirin.
Q. Is tizanidine an opiate, NSAID, blood thinner, controlled substance, or muscle relaxer?
Tizanidine is not an opiate, NSAID, blood thinner or a controlled substance. It is a muscle relaxant.
Q. Is tizanidine like valium?
Valium is a brand name for drug diazepam. It is also used as a muscle relaxant, but both have different functions. Please consult your doctor before taking the drug.
Q. Is tizanidine stronger than Flexeril?
Flexeril is a brand name for drug cyclobenzaprine, which is also used as a muscle relaxant. Effect of the drug may vary upon individual response. Please consult your doctor before taking the drug.
Q. Is tizanidine water soluble?
Tizanidine is a lipid-soluble drug; it is only slightly soluble in water and methanol.
Q. Is tizanidine gluten free?
Tizanidine is gluten free. However, please refer to package insert of the prescribed brand before use.
Q. Can I take tizanidine or Zanaflex for menstrual cramps, headaches, or anxiety?
No, you cannot take tizanidine or Zanaflex (which contains tizanidine) for menstrual cramps, headaches, or anxiety. Please consult your doctor before taking the drug.
Q. Does tizanidine cause weight loss or keep you awake (insomnia)?
You may experience insomnia or weight loss with the use of tizanidine. Few people may experience excessive sleepiness. If you experience such side effects, consult your doctor.
Q. Can I take tizanidine with Aleve (naproxen), Ambien (zolpidem), Norco (acetaminophen and hydrocodone), Tylenol (paracetamol), Valium (diazepam), or Xanax (alprazolam)?
You may take Aleve and Tylenol with tizanidine, but Ambien, Norco, Valium, and Xanax should not be given with tizanidine. Consult your doctor before simultaneous use.
Q. Can I take tizanidine with prednisone, ibuprofen, tramadol, or oxycodone?
Tizanidine may be taken with prednisone or ibuprofen, but tramadol or oxycodone with tizanidine may increase their side effects. Consult your doctor before simultaneous use.
Q. Does tizanidine show on a drug test?
No, tizanidine does not show on a drug test. Only narcotic drugs show up on a drug test.


Content on this page was last updated on 06 April, 2014, by Dr. Varun Gupta (MD Pharmacology)