Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. COXINEX 450MG/300MG CAPSULE is to be taken empty stomach. Avoid COXINEX 450MG/300MG CAPSULE with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
COXINEX 450MG/300MG CAPSULE is a combination of two antibiotics: Rifampicin and Isoniazid which treat tuberculosis (TB). Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce. Isoniazid prevents these bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.
COXINEX 450MG/300MG CAPSULE may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
WEIGH RISKS VS BENEFITS
COXINEX 450MG/300MG CAPSULE may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
COXINEX 450MG/300MG CAPSULE is safe to use during lactation.
Human studies have shown that either the drug does not pass into the breastmilk in significant amount or is not expected to cause toxicity to the baby.
Do not drive unless you are feeling well. COXINEX 450MG/300MG CAPSULE can cause fits, mental health problems and optic neuritis (inflammation of the optic nerve that may cause loss of vision.) This may affect your driving ability.
COXINEX 450MG/300MG CAPSULE should be used with caution in patients with kidney disease. Dose adjustment of COXINEX 450MG/300MG CAPSULE may be needed. Please consult your doctor.
COXINEX 450MG/300MG CAPSULE should be used with caution in patients with liver disease. Dose adjustment of COXINEX 450MG/300MG CAPSULE may be needed. Please consult your doctor. Use of COXINEX 450MG/300MG CAPSULE is not recommended in patients with severe liver disease.
Coxinex is a combination of two medicines: Rifampicin and Isoniazid. It is used in the treatment of tuberculosis. Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by tuberculosis bacteria to make essential proteins and to reproduce. Isoniazid prevents the tuberculosis causing bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.
Q. What is the most important information I should know about the Coxinex?
Take the proper course of drug that has been prescribed for you even if you begin to feel better. Avoid alcohol while taking this medicine as it increases the risk of damage to your liver during treatment. Tell your doctor immediately if you experience vision changes, loss of appetite, tiredness, stomach pain, nausea or vomiting, yellow skin or eyes or dark-colored urine.
Q. Which is the best time to take Coxinex?
Take the Coxinex exactly as directed by your doctor. It is best to take the medicine on an empty stomach one hour before or two hours after meals.
Q. Does Coxinex cause change in urine color/turn urine orange?
Yes, the Coxinex can cause change in color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful.
Q. Does the use of Coxinex makes birth control pills ineffective
Yes, Coxinex can make birth control pills less effective. Ask the doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking Coxinex.
Information last updated by Dr. Varun Gupta, MD Pharmacology on 23rd Aug 2017.