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Comantrel 100 mg Tablet

Prescription Required


Introduction of Comantrel Tablet

Comantrel 100 mg Tablet is a prescription medicine used in the treatment of Parkinson's disease. It is also used for prophylaxis of uncomplicated upper respiratory tract infection caused by influenza virus.

Comantrel 100 mg Tablet works by increasing the amount of dopamine, a chemical messenger that is needed to control the abnormal movements. It is taken by mouth with or without food preferably at bedtime. However, take it at the same time each day as this helps to maintain consistent level of medicine in the body. Take this medicine in the dose and duration as advised by doctor and if you have missed a dose, take it as soon as you remember it. You should finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to doctor. This medicine may put you at a higher risk of having seizures, so it is better to talk to doctor if you have any history of seizures or taking medication for it.

Some common side effects of this medicine includes blurred vision, dryness in mouth, constipation, hallucinations and balance disorder (loss of balance). It may initially cause dizziness and lowering of blood pressure while standing, so rise slowly and do not drive or do anything that requires mental focus until you know how this medicine affects you. It is important to inform doctor if you develop any unusual changes in mood, an abnormally high sex drive, an urge to gamble or uncontrolled spending as these may prove very harmful.

Uses of Comantrel Tablet

Comantrel Tablet side effects

  • Nausea
  • Dryness in mouth
  • Constipation
  • Dizziness
  • Blurred vision
  • Insomnia (difficulty in sleeping)
  • Hallucination
  • Peripheral edema
  • Balance disorder (loss of balance)
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)

How to use Comantrel Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Comantrel 100 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Comantrel Tablet works

Comantrel 100 mg Tablet is a dopamine agonist that treats Parkinson's disease. It works by increasing the amount of dopamine, a chemical messenger in the brain which regulates body movements. It also has an antiviral property. It works against viruses to prevent their growth and multiplication. It also appears to restricts the viruses to release infectious chemicals (viral nucleic acid) to enter into the body. Thus, it prevents and treats Influenza infection.

Comantrel Tablet related warnings

It is unsafe to consume alcohol with Comantrel 100 mg Tablet
Comantrel 100 mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Comantrel 100 mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Comantrel 100 mg Tablet may cause side effects which could affect your ability to drive.
Comantrel 100 mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Comantrel 100 mg Tablet may be needed. Please consult your doctor.
Use of Comantrel 100 mg Tablet is not recommended in patients with severe kidney disease.
Comantrel 100 mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Comantrel 100 mg Tablet may be needed. Please consult your doctor.
It may cause a transient increase in liver enzymes.

What if you miss a dose of Comantrel Tablet?

If you miss a dose of Comantrel 100 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Comantrel 100 mg Tablet
Parkitidin Tablet
Sun Pharmaceutical Industries Ltd
18% costlier
Amantex Tablet
Intas Pharmaceuticals Ltd
18% costlier
32% costlier

Expert Advice

  • You have been prescribed Comantrel 100 mg Tablet to treat your symptoms of Parkinson's disease.
  • It can be taken with or without food.
  • It may cause blurring of vision or affect mental ability. Do not drive or do anything requiring concentration until you know how it affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • Do not take extra medicine to make up for the missed dose.
  • It may put you at a higher risk of having seizures. Talk to your doctor if you have a history of seizures or are taking medication for it.
  • Inform your doctor if you notice an urge to gamble, increased sexual urges, binge eating, or uncontrolled spending.
  • Do not stop taking the medication suddenly without talking to your doctor.

Interaction with Drugs

Taking Comantrel with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Pramipex, Pramipar, Prarimol SR
Brand(s): Bupro, Bupep, Bunocare

Patient Concerns

Questions Related to Comantrel

Hi my mom had Parkinson's disease but didn't get any operation but using tablets syndopa last night she take another tablet of pain killer with it by the morning my mom to full shivering of hands and legs so what do u suggest to do?
Dr. Vikas Sharma
need to examine to opine
Parkinson's disease for 25 yrs. Taking allopathy Suggestions needed
Dr. Deepak Kumar Soni
Skin Specialist
Kindly consult to any good Ayuvedic Panchkarma center. Panchkarma therapy will give you some result .
Do you have any questions related to Comantrel 100 mg Tablet?

User Feedback


Q. Does Comantrel cause constipation?

Yes, constipation is a common side effect of Comantrel, though it does not occur in everyone. Consult your doctor or a dietician if constipation persists and is troublesome.

Q. Is Comantrel used for pain?

Though it is not an approved use, Comantrel has been shown to be effective in relieving pain related to nerve disorder. Comantrel is a prescription medicine, and you should take it for relief of pain only if advised by the doctor.

Q. Does Comantrel cause fatigue?

Yes, Comantrel causes fatigue and sleepiness which may affect some patients’ ability to drive and operate machinery safely.

Q. What happens when I stop taking Comantrel?

Do not stop taking this medicine or lower the dose without first checking with your doctor. If required, your doctor will gradually reduce the amount you take each day before stopping it completely. Abruptly stopping Comantrel may result in worsening of Parkinsonism. It may also cause delirium, agitation, delusions, hallucinations, paranoid reaction, stupor, anxiety, depression, or slurred speech.

Q. Is Comantrel a dopamine agonist?

Yes, Comantrel is a dopamine agonist. Dopamine is needed to control movements in the brain. Comantrel works by increasing the amount of dopamine, thereby helping in controlling the movements in Parkinson’s disease.

Q. Can I take Comantrel any time during the day? Should the dose be taken before meal?

Yes, Comantrel can be taken at any time during the day, with or without food. Try to take the medicine at about the same time each day, as directed by your doctor. Taking your medicine at the same time each day will have the best effect. It will also help you to remember when to take your medicine.

Q. Can Comantrel get you high?

The use of Comantrel may cause impulse control disorders in which you may have strong urges to gamble, increased sexual urges, intense urges to spend money, binge eating, and other intense urges. Additionally, there is the inability to control these urges. If such symptoms are experienced then dose reduction or tapered discontinuation should be considered.

Q. Does Comantrel affect fertility?

No, Comantrel is not known to affect fertility in humans.

Q. Can Comantrel cause weight loss?

Decreased weight and body mass index may occur with continued Comantrel usage. If you have any concerns regarding weight loss consult your doctor or a nutritionist.

Related Products

Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
  1. Aminoff MJ. Pharmacologic Management of Parkinsonism & Other Movement Disorders. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 477.
  2. Standaert DG, Roberson ED. Treatment of Central Nervous System Degenerative Disorders. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 619.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 48-49.
  4. Amantadine. Bridgewater, New Jersey: Vertical Pharmaceuticals, LLC; 1966 [revised Feb. 2018]. [Accessed 19 Jun. 2019] (online) Available from:External Link
  5. Amantadine hydrochloride. Walsall, UK: Fontus Health Ltd.; 2019. [Accessed 19 Jun. 2019] (online) Available from:External Link
  6. Amantadine hydrochloride. North Ryde, New South Wales: NOVARTIS Pharmaceuticals Australia Pty Limited; 2014. [Accessed 19 Jun. 2019] (online) Available from: External Link
  7. ScienceDirect. Amantadine. [Accessed 19 Jun. 2019] (online) Available from:External Link
  8. Amantadine Pregnancy and Breastfeeding Warnings. [Accessed 19 Mar. 2019] (online) Available from:External Link
  9. U.S. National Library of Medicine. Amantadine. [Accessed 19 Mar. 2019] (online) Available from:External Link
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Manufacturer/Marketer Address
Consern Pharma Private Limited, Kuljive Mahajan(Mg. Director), Rural Focal Point, V.P.O. Tibba, Ludhiana - 141120, Punjab, India
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