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MRP: Rs. 346 for 1 vial(s) (1.5 ML injection each)
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Composition for CAFIRATE

Caffeine(20 mg)

food interaction for CAFIRATE

alcohol interaction for CAFIRATE

pregnancy interaction for CAFIRATE

lactation interaction for CAFIRATE

It can be taken with or without food, but it is better to take Cafirate 20 mg injection at a fixed time.
Taking caffeine with alcohol may impair the motor coordination
Cafirate 20 mg injection may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Caffeine(20 mg)


Cafirate 20 mg injection is used in combination with pain killers (aspirin and paracetamol) to ease pain that includes headache, migraine, neuralgia, toothache, sore throat, period pains, relief of sprains, strains, rheumatic pain, muscular aches and pains, joint swelling and stiffness, influenza, feverishness and feverish colds. As Cafirate 20 mg injection citrate, it is used to treat absence of breathing seen in newborns (primary apnea of premature newborns).

How it works

Cafirate 20 mg injection is a drug which belongs to a group of medicines called methylxanthines. Cafirate 20 mg injection acts against a chemical called adenosine in the body, and thereby reduces pain. Cafirate 20 mg injection also stimulates the brain (central nervous system), heart, and muscles and improves the drive to breathe.

Common side effects

Frequent urge to urinate, Abdominal pain, Anxiety, Excitement, Flushing, Altered heart rate, Insomnia, Restlessness, Tremor


2 Substitutes
Sorted By
    (2 ML injection in vial)
    Cipla Ltd
    Rs. 236.50/ML of injection
    Rs. 473
    save 32% more per ML of injection
    (1 ML injection in vial)
    Cipla Ltd
    Rs. 242/ML of injection
    Rs. 242
    save 30% more per ML of injection

Top General Physicians

  • Dr. Balbir Singh
    MBBS, MD, DM, Fellowship, Fellowship
  • Dr. (Col.) Balbir Kalra
    MBBS, MD, DM
  • Dr. Manjinder Sandhu
    MBBS, MD, DNB, DM, Fellowship, Fellowship
  • Dr. Monik Mehta
    MBBS, MD, DM, Fellowship
  • Dr. Tapan Ghose
    MBBS, DNB, MD, DNB, Fellowship, Fellowship

Expert advice for CAFIRATE

  • For relief of pain, consume the medicine only at recommended doses. Immediately consult doctor in case you take more than the prescribed/ recommended dose even if you feel well. Also consult the doctor if the symptoms last for more than 3 days despite taking the medicine.
  • Preparations of caffeine and ergot derivatives have been discontinued in view of patient safety.
  • When caffeine citrate solution is used for premature apnea of newborns, remember to use one vial of the drug for one dose. Throw away the left-over solution after required amount is used.

Frequently asked questions for CAFIRATE


Q. What is caffeine? 
Caffeine is a drug which belongs to a group of medicines called methylxanthines. It is also present in tea, coffee, some chocolates and soft drinks, in addition to some medicines. It acts on the brain to increase alertness and energy levels. However, too much caffeine is harmful.
Q. Is caffeine alcohol? 
No, caffeine is not alcohol; it belongs to a group of medicines called methylxanthines. It acts on the brain to increase alertness and energy levels. However, it must be remembered that too much caffeine is harmful.
Q. Is caffeine good or bad?
Caffeine; if taken as medicine for recommended indications and in adequate dosage it provides beneficial effects. Too much caffeine is harmful. Always consult your doctor if you get any of the bad effects or side effects after use of caffeine.
Q. Is caffeine good for hair?
There is no report available on the use of caffeine and hair growth. Patients should follow the advice of the doctor regarding its use.
Q. Is caffeine addictive?
No, caffeine is not in the list of addictive drugs. Addiction is said to occur when there is persistent, compulsive dependence on a behavior or substance; without treatment or engagement in recovery activities, addiction is progressive and can result in disability or premature death. Caffeine does not meet this definition. However, people who have taken it for long may experience "caffeine withdrawal" symptoms like headache, anxiety, fatigue, drowsiness or depression, 12–24 hours after the last dose of caffeine but resolves within 24–48 hours. 
Q. Is caffeine good for heart?
Caffeine is a central nervous system stimulant, and is used in combination with pain-relieving medication to ease headache, migraine pain, neuralgia, toothache, sore throat and period pains. Increased doses may have side effects like increased heart rate (tachycardia), abnormal heart beats (cardiac arrhythmias). Always consult your doctor for the recommended indications, doses and side effects, if any.


Content on this page was last updated on 15 October, 2014, by Dr. Varun Gupta (MD Pharmacology)