Angina pectoris, cardiac failure, cardiopulmonary oedema, long-term treatment of healed reflux oesophagitis, moderate to severe reflux oesophagitis, myocardial infarction, oesophageal spasm, postoperative hypertension, prinzmetal's angina.
Nitroglycerin is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
tachycardia, flushing, restlessness, neurologic deficit, syncope, vertigo, nausea, metabolic acidosis, bradycardia, urinary incontinence., abdominal pain, vomiting, cardiovascular collapse, palpitation, coma, Tachycardia, dizziness, hypotension, collapse, headache, palpitations, weakness