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MDS (Oral Pathology & Microbiology), BDS
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Last updated on:
14 May 2019 | 05:16 PM (IST)
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Apriglim-M 2 Tablet SR


Overview

Introduction

Apriglim-M 2 Tablet SR is a medicine used in the treatment of type 2 diabetes. It is a combination of two medicines that effectively control blood sugar levels, when a single medication is not effective. It should be used along with a proper diet and regular exercise for best results. It should be taken with food to avoid the side effects like nausea and upset stomach.

Uses of Apriglim-M Tablet SR

Apriglim-M Tablet SR side effects

Common
  • Hypoglycemia (low blood sugar level)
  • Taste change
  • Nausea
  • Diarrhea
  • Stomach pain
  • Headache
  • Upper respiratory tract infection

How to use Apriglim-M Tablet SR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Apriglim-M 2 Tablet SR is to be taken with food.
Apriglim-M 2 Tablet SR may cause stomach upset if taken empty stomach.

How Apriglim-M Tablet SR works

Apriglim-M 2 Tablet SR is a combination of two antidiabetic medicines: Glimepiride and Metformin. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide which works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin.

Apriglim-M Tablet SR related warnings

Alcohol
CAUTION
It is unsafe to consume alcohol with Apriglim-M 2 Tablet SR. Taking metformin with alcohol can cause lactic acidosis and you may experience malaise, respiratory distress, slow or irregular heartbeat, sleepiness, stomach upset, or other unusual symptoms.
Pregnancy
WEIGH RISKS VS BENEFITS
Apriglim-M 2 Tablet SR may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Lactation
Apriglim-M 2 Tablet SR is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.
Driving
Your ability to drive may be affected if your blood sugar is low or high. If this happens, do not drive.
Kidney
CAUTION
Apriglim-M 2 Tablet SR should be used with caution in patients with kidney disease. Dose adjustment of Apriglim-M 2 Tablet SR may be needed. Please consult your doctor.
Use of Apriglim-M 2 Tablet SR is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Liver
CAUTION
Apriglim-M 2 Tablet SR should be used with caution in patients with liver disease. Dose adjustment of Apriglim-M 2 Tablet SR may be needed. Please consult your doctor.
Apriglim-M 2 Tablet SR is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.

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Expert Advice

  • Monitor your blood sugar level regularly while you are taking this medicine. 
  • It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. 
  • Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.
  • Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Apriglim-M 2 Tablet SR may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
  • Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

Patient Concerns

Questions Related to Apriglim-M

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Hi Doctor I have Type 2 diabetes, at present i m taking istamet 50/1000 mg, kindly advise if my medicine can be stopped
Dr. Shikha Mishra
Dietician
Please consult doctor regarding this issue
I was diagnosed with type 2 diabetes in January and I m taking medicine. Now it's under control. Can you suggest me a meal plan that I can go for to control my weight and diabetes. Thank you
Dr. Shikha Mishra
Dietician
eat 6-7 meals per day, which consist fruits, nuts, buttermilk,egg, homecooked food. Drink 3-4 litters of water.Be active whole day for personalized diet chart write to me on shikhamishra.nutrition@gmail.com do minimum 45 min exercise everyday like yoga, cardio or weights
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Do you have any questions related to Apriglim-M 2 Tablet SR?

User Feedback


FAQs

Q. What are the recommended storage conditions for Apriglim-M?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. Can the use of Apriglim-M lead to lactic acidosis?

Yes, the use of Apriglim-M can lead to lactic acidosis. It is a medical emergency which is caused by increased levels of lactic acid in the blood. It is also known as MALA (Metformin-associated lactic acidosis). It is a rare side effect associated with the use of metformin and therefore, it is considered to be harmful for patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Apriglim-M and consult your doctor immediately.

Q. What is Apriglim-M?

Apriglim-M is a combination of two medicines: Glimepiride and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves blood glucose levels in adults when taken along with proper diet and regular exercise. Glimepiride lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. This combination is not indicated for the treatment of type 1 DM.

Q. What are the possible side effects of Apriglim-M?

The use of Apriglim-M is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use it can also lead to Vitamin B12 deficiency.

Q. Can the use of Apriglim-M lead to Vitamin B12 deficiency?

Yes, the use of Apriglim-M can cause Vitamin B12 deficiency on long-term use. It interferes with the absorption of Vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can experience tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of Vitamin B12 from outside sources at least once every year.

Q. Can the use of Apriglim-M cause hypoglycemia?

Yes, the use of Apriglim-M can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of the blood sugar level is important. Always keep a quick source of sugar like glucose tablets, honey or fruit juice with you.

Q. Is it safe to take alcohol while I am also taking Apriglim-M?

No, it is not safe to take Apriglim-M along with alcohol, as it may lower your blood sugar levels and lead to hypoglycemia. It can also increase the chances of lactic acidosis.

Related Products

Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Glimepiride + Metformin. Karachi, Pakistan: Sanofi-Aventis Pakistan Ltd. [Accessed 23 Jan. 2019] (online) Available from:External Link
  2. Metformin Hydrochloride Prolonged Release & Glimepiride Tablets I.P. Ankleshwar: Sanofi India Limited; 2018. [Accessed 08 Apr. 2019] (online) Available from:External Link
  3. Glimepiride. Bridgewater, New Jersey: Sanofi-Aventis U.S. LLC.; 2009. [Accessed 08 Apr. 2019] (online) Available from:External Link
  4. Metformin hydrochloride. Princeton, New Jersey: Bristol-Myers Squibb Company. [Accessed 08 Apr. 2019] (online) Available from:External Link
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