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18 Feb 2020 | 05:25 PM (IST)
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Anticox II 450 mg/300 mg Tablet


Overview

Introduction

Anticox II 450 mg/300 mg Tablet is a combination medicine used in the treatment of tuberculosis. It prevents the growth of the microorganisms that cause the infection.

Anticox II 450 mg/300 mg Tablet is a prescription medicine and it is to be taken as suggested by the doctor. It should be taken in an empty stomach and take it at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine. The medicine may take some to show its effects on the symptoms. However, it is advised to consult the doctor if you feel an aggravation of the condition or if your condition does not improve.

Some common side effects of this medicine are nausea, vomiting, fever, dark-colored urine, sweating, increased saliva, etc. To cope up with the side effects, you should drink plenty of water. If any of the side effects get aggravated, you must consult your doctor immediately. Generally, serious side effects are rare. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.

Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Patients with liver and kidney ailments must take this medicine with proper consultation and caution. Pregnant or breastfeeding women should also consult with the doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. During the treatment, you must take adequate rest and eat a healthy diet for a faster recovery. While on the medication, your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.

Uses of Anticox II Tablet

Side effects of Anticox II Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Anticox II

  • Dark colored urine
  • Rash
  • Vomiting
  • Jaundice
  • Fever
  • Increased liver enzymes
  • Nausea
  • Peripheral neuropathy (tingling and numbness of feet and hand)

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Rash
    There are many treatments for a wide range of skin problems. Avoid hot showers or baths because hot water can irritate the skin. Make sure to pat dry your skin after a bath or shower. Do not rub or scratch the affected area. Leave the skin exposed to the air as much as possible. Do not use perfumed soaps or deodorants. Water containing chlorine can make most skin problems worse, so avoid swimming. Avoid spicy foods, alcohol, tobacco smoke and caffeine as it may also make itching worse. Avoid excessive sun exposure. Always use sunscreen and protective clothing when outdoors. Moisturizers can be used regularly to soothe and hydrate the affected area. If it does not get better within a week, speak to a pharmacist or doctor.
  • Coping with Vomiting
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Increased liver enzymes
    There may be no symptoms, so your doctor should carry out a blood test and give you advice. Some lifestyle changes can bring down levels of liver enzymes. In general, you will need to stop drinking alcohol or limit the amount you drink, lose weight and keep active. Drink plenty of fluids to avoid dehydration. Eat a healthy diet. Some particular foods like nuts, fatty fish, coffee, tea, olive oil, sprouts and bananas may be beneficial. Try to control stress as this can make your symptoms worse.
  • Coping with Nausea
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop from feeling sick. Speak to your doctor if your condition does not improve.

How to use Anticox II Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Anticox II 450 mg/300 mg Tablet is to be taken empty stomach.
Avoid Anticox II 450 mg/300 mg Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

How Anticox II Tablet works

Anticox II 450 mg/300 mg Tablet is a combination of two antibiotics: Rifampicin and Isoniazid, which treats tuberculosis (TB). Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce. Isoniazid prevents these bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.

Safety Advice

Alcohol
UNSAFE
Consuming alcohol while taking Anticox II 450 mg/300 mg Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Pregnancy
CONSULT YOUR DOCTOR
Anticox II 450 mg/300 mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
SAFE IF PRESCRIBED
Anticox II 450 mg/300 mg Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Driving
UNSAFE
Anticox II 450 mg/300 mg Tablet may cause side effects which could affect your ability to drive.
Anticox II 450 mg/300 mg Tablet can cause fits, mental health problems and optic neuritis (inflammation of the optic nerve that may cause loss of vision.) This may affect your driving ability.
Kidney
CAUTION
Anticox II 450 mg/300 mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Anticox II 450 mg/300 mg Tablet may be needed. Please consult your doctor.
Liver
CAUTION
Anticox II 450 mg/300 mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Anticox II 450 mg/300 mg Tablet may be needed. Please consult your doctor.
Use of Anticox II 450 mg/300 mg Tablet is not recommended in patients with severe liver disease.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
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Quick Tips

  • You have been prescribed Anticox II 450 mg/300 mg Tablet for the treatment of tuberculosis.
  • Finish the full course of the medication, even if you feel better. Stopping it early may make the infection come back.
  • Take it on an empty stomach, preferably at the same time everyday.
  • It may discolour your urine, sweat, saliva and tears a reddish-orange colour. This is normal and not harmful.
  • Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
  • Avoid drinking alcohol while taking Anticox II 450 mg/300 mg Tablet as this may increase the risk of side effects on the liver.
  • Use an alternative or additional contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Anticox II 450 mg/300 mg Tablet as it may make hormonal contraceptives such as the pill less effective.
  • Do not take indigestion remedies (antacids)  within at least two hours of taking Anticox II 450 mg/300 mg Tablet.

Fact Box

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Patient Concerns

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Is there any medicine to control Diabetes
Dr. Faran Siddiqui
Homeopathy
DM type I or II please b more elaborate on subject
My father 76 year old having type II diabetes. had given him forxiga 10 mg 1 tablet every day. Is it suitable to him
Dr. Ashwin Porwal
Internal Medicine
i need complete history and investigations
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User Feedback


FAQs

Q. What are the instructions for storage and disposal of Anticox II?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. What is Anticox II?

Anticox II is a combination of two medicines: Rifampicin and Isoniazid. It is used in the treatment of tuberculosis. Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by tuberculosis bacteria to make essential proteins and reproduce. Isoniazid prevents the tuberculosis causing bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.

Q. What is the most important information I should know about the Anticox II?

Take the proper course of drug that has been prescribed to you. Do not stop in between even if you begin to feel better. Avoid alcohol while taking this medicine as it increases the risk of damage to your liver during treatment. Tell your doctor immediately if you experience vision changes, loss of appetite, tiredness, stomach pain, nausea or vomiting, yellow skin or eyes or dark-colored urine.

Q. What is the best time to take Anticox II?

Take Anticox II exactly as directed by your doctor. It is best to take the medicine on an empty stomach one hour before or two hours after meals.

Q. Does Anticox II cause change in urine color/turn urine orange?

Yes, Anticox II can change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful.

Q. Does the use of Anticox II make birth control pills ineffective?

Yes, Anticox II can make birth control pills less effective. So, ask the doctor about using a birth control method which does not affect your hormone levels (such as a condom, diaphragm and spermicide).

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Isoniazid/rifampicin. Guildford Surrey: Aventis Pharma Limited; 1999 [revised 12 Mar. 2019]. [Accessed on 10 Apr. 2019] (online) Available from:External Link
  2. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Hilal-Dandan R, Brunton LL. Goodman and Gilman's Manual of Pharmacology and Therapeutics. 2nd ed. New York, New York: The McGraw-Hill Companies, Inc.; 2014. [Accessed 10 Apr. 2019] (online) Available from:External Link
  3. Isoniazid. Nottingham, Nottinghamshire: Boots Contract Manufacturing; 2015. [Accessed 10 Apr. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
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We do not facilitate sale of this product at present

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