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AMPHOMUL 50 MG INJECTION


Overview

Introduction

AMPHOMUL 50 MG INJECTION is an antifungal medication. It is used in the treatment of severe fungal infections and kala-azar. It kills the infection causing fungi and thus, treats the infection.

AMPHOMUL 50 MG INJECTION is administered as an injection by a healthcare professional. Kindly do not self administer. Before you take this medicine, inform your doctor if you suffer from diabetes, liver/kidney problems or are on dialysis or have low potassium level in blood.

It may lead to a few common side effects like headache, vomiting, nausea, stomach cramps and fever. You may also notice some injection site reactions like pain, swelling or redness. Inform your doctor if these side effects persist for a longer duration. Please consult your doctor if you are pregnant, planning to conceive or breastfeeding.

Uses of Amphomul Injection

Side effects of Amphomul Injection

Common
  • Headache
  • Vomiting
  • Nausea
  • Stomach cramp
  • Fever
  • Anemia (low number of red blood cells)
  • Heartburn
  • Hyperventilation (rapid breathing)

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Headache
    Make sure you rest and drink plenty of fluids. Rest in a quiet, dimly lit room. Do not sleep more than you normally would. Do not strain your eyes (for example by looking at a screen). Do not drink alcohol. Headaches are usually temporary and usually go away with time. But, if they last longer or get worse, ask your doctor to recommend a painkiller.
  • Coping with Vomiting
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Nausea
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop from feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Stomach cramp
    In most cases, this is mild enough to be treated at home. Try to rest and relax. Putting a heat pad or covered hot water bottle on your stomach may also help. Having a warm bath or shower can help you relax and relieve the pain. Drink plenty of clear fluids such as water and reduce your intake of coffee, tea, lemon juice or soda. Avoid alcohol and smoking as these can aggravate the pain. Eating slowly and having smaller and more frequent meals can also help. If the pain is severe, speak to your doctor. They may be able to guide you better.
  • Coping with Anemia (low number of red blood cells)
    Making some simple lifestyle changes can raise your red blood cell count. Reduce the amount of alcohol you drink, eat a well-balanced healthy diet and take regular exercise. Physical activities make your body need more oxygen and this stimulates the production of red blood cells. There are some vitamins which are important such as vitamin B-12, vitamin B-9, vitamin C and Vitamin A. Also, some minerals such as iron (especially) and copper. Aim for foods which contain higher quantities of these vitamins and minerals or ask your doctor for supplements. Make sure to consult your doctor for complete evaluation and treatment of anemia.
  • Coping with Heartburn
    Avoid foods that irritate the stomach such as alcohol, carbonated soft drinks, citrus, coffee, fatty foods or tomatoes. Eat or drink slowly. Eat smaller, more frequent meals. The reason being, large meals fill the stomach and put pressure, causing reflux. Quit smoking if you smoke, lose weight if you are overweight and avoid tight waistbands. Ask your doctor about medicines to treat this condition such as antacids. Do not lie down immediately after eating and wait for at least three hours before lying down after a meal. Raise the head of your bed. Talk to your doctor if your condition does not improve, they may be able to reduce the dosage or switch you to another medicine.

How to use Amphomul Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Amphomul Injection works

AMPHOMUL 50 MG INJECTION is an antifungal medication. It kills fungi by destroying the fungal cell membrane.

Safety Advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with AMPHOMUL 50 MG INJECTION. Please consult your doctor.
Pregnancy
SAFE IF PRESCRIBED
AMPHOMUL 50 MG INJECTION is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breastfeeding
CONSULT YOUR DOCTOR
AMPHOMUL 50 MG INJECTION is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
AMPHOMUL 50 MG INJECTION may cause side effects which could affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
AMPHOMUL 50 MG INJECTION is safe to use in patients with kidney disease. No dose adjustment of AMPHOMUL 50 MG INJECTION is recommended.
However, inform your doctor if you have any underlying kidney disease.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of AMPHOMUL 50 MG INJECTION in patients with liver disease. Please consult your doctor.

What if you forget to take Amphomul Injection?

If you miss a dose of AMPHOMUL 50 MG INJECTION, please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
AMPHOMUL 50 MG INJECTION
₹161.22/ml of Injection
₹29.51/ml of Injection
save 82%
Amphotret 50mg Injection
Bharat Serums & Vaccines Ltd
₹309.03/Injection
92% costlier
Amphonex 50mg Injection
Bharat Serums & Vaccines Ltd
₹4037.07/Injection
2404% costlier
₹4735/Injection
2837% costlier
₹4784.75/Injection
2868% costlier

Quick Tips

  • It is usually given as an injection over 1-2 hours under the supervision of a medical professional.
  • AMPHOMUL 50 MG INJECTION can cause rash, chills, headache, and tiredness during initial days of the treatment, but these may fade away with time.
  • Your doctor may ask you for regular blood tests to monitor your blood sugar, potassium, magnesium and kidney function.
  • Inform your doctor immediately if you notice pain or blood upon urination, swelling of the face and trouble breathing.
  • Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. 

Interaction with Drugs

Taking Amphomul with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Abamune, A-Bec, Virol
SERIOUS
Brand(s): Adesera, Adheb, Adfovir
SERIOUS
Brand(s): Mikasun, Vizocin, Amricin
SERIOUS
Brand(s): Densol
SERIOUS

Patient Concerns

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I have been experiencing fungal infections, I develop rings and rashes and they all itch like anything. I formed scars because of it. I have been taking Grisovin FP 250 mg however as long I take it I am relieved, even if I miss it for 1 day I start getting fungus back. On top of that Grisovin FP is difficult to find now, please suggest.
Dr. Atul Jain
Dermatology
You are having fungal infections severe, you need to change the medicine by skin specialistCan b prescribed under supervisionMeanwhile apply onabet cream twice a day
Fungal infections on face and body
Dr. Atula Gupta
Dermatology
Cap. Itraconazole (Itrasys/ Canditral) 100mg twice daily for 2 weeks. Sertacide Cream for application twice daily for 1 month.Tab. Fexova 180 mg (if required in case of itching)
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Do you have any questions related to AMPHOMUL 50 MG INJECTION ?

FAQs

Q. Is Amphomul fungistatic or fungicidal?

Amphomul is fungicidal in nature, it acts by killing the fungus

Q. Is Amphomul light sensitive?

Amphomul is not light sensitive

Q. What is Amphomul liposomal?

Liposomal Amphomul is a lipid-associated formulation. Liposomal encapsulation or incorporation into a lipid complex of Amphomul can substantially improves drug safety especially nephrotoxicity associated with the drug

Q. Is Amphomul an antibiotic?

Yes, Amphomul is an antifungal antibiotic for the treatment of serious infections caused by fungi like fungal infections of one or more deep organs of the body, suspected fungal infections in patients with a raised temperature and neutropenia (reduced number of white blood cells [neutrophils]) and Visceral leishmaniasis (disease caused by a parasite)

Q. Is Amphomul testing dose needed?

Yes, administration of Amphomul is associated with allergy (severe and serious allergic) reaction, therefore it is recommended to administer a test dose before starting the therapy to check for sensitivity

Q. How is Amphomul administered?

Amphomul is either administered as intravenous injection or infusion by a registered medical professional only

Q. How does Amphomul cause nephrotoxicity and hyperkalemia?

Amphomul can disrupt the lipid components of human kidney cells, thereby causing nephrotoxicity. The exact mechanism of hypokalemia is not known, but kidney damage may result in excessive loss of potassium in urine.

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Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Phillips MA, Stanley SL Jr. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1424.
  2. Bennett JE. Antifungal Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1571-75.
  3. Sheppard D, Lampiris HW. Antifungal Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 836-38.
  4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 68-69.
  5. Medsacpe. Amphotericin. [Accessed 29 Mar. 2019] (online) Available from:External Link
  6. Amphotericin B. San Dimas, California: Gilead Sciences, Inc.; 2000. [Accessed 04 Feb. 2019] (online) Available from:External Link
  7. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. Jornal de Pediatria. 2004; 80(5):4-6. [Accessed 29 Mar. 2019] (online) Available from:External Link
  8. Central Drugs Standard Control Organisation (CDSCO). [Accessed 29 Mar. 2019] (online) Available from:External Link
Manufacturer/Marketer Address
17th Floor, Hoechst House, Nariman Point, Mumbai – 400 021, Maharashtra, India.
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We do not facilitate sale of this product at present

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