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1 year ago
What causes neuropathy in diabetes patients? Is any of the nerve damage reversible?
1 Answer
1 year ago
The exact cause of Diabetic neuropathy is not clear. There are many factors that are known to contribute towards this condition, the most important being high blood sugar levels. Causes include: 1. Reduced blood flow: Diabetes causes reduced blood vessel relaxation leading to impaired flow to nerves 2. Damage to nerve proteins: Depletion of myelin proteins which are important for nerve conduction. Glycosylation of structural nerve proteins leading to decreased nerve conduction 3. Oxidative stress: Increased production of oxygen free radicals producing oxidative stress and damage 4. Accumulation of sorbitol and fructose in nerves. Risk factors include: 1. Poor blood sugar control 2. Alcohol intake 3. High blood pressure 4. Smoking 5. High cholesterol levels 6. Obesity 7. Older age 8. Family history 9. Duration of diabetes Depending on the extent of damage and the function that is impaired due to nerve damage, it is sometimes possible to reverse or slow down the damage by medications and lifestyle changes.
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