Apolipoprotein B/A1 Ratio

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Blood

This test is for

Male, Female

Understanding Apolipoprotein B/A1 Ratio

What is Apolipoprotein B/A1 Ratio?

An Apolipoprotein B/A1 Ratio test represents the balance between two lipoproteins in the blood, namely, apolipoprotein B (apo B) and apolipoprotein A1 (apoA1). This test provides valuable information about an individual's cardiovascular health and can help doctors make informed decisions regarding prevention and treatment strategies.

Apolipoprotein A1 and B are cardiac biomarkers that appear in the blood after your heart has been under severe stress or injury. These markers are valuable indicators that healthcare advisors can utilize for a more comprehensive assessment of cardiac risk factors and to tailor preventive measures and treatments.

These lipoproteins are involved in the transport of cholesterol and other lipid (fat) molecules in the blood. Apo B is a protein found in LDL (low-density lipoprotein) particles, commonly called bad cholesterol. Apo A1 is a protein found in HDL (high-density lipoprotein) particles, often termed good cholesterol. The ratio of these two lipoproteins helps analyze the cardiovascular risk for an individual. A higher ratio indicates a higher risk of cardiovascular disease, suggesting a higher proportion of LDL particles than HDL particles. Conversely, a lower ratio is associated with a lower risk.

While standard lipid profile tests measure cholesterol levels, an Apolipoprotein B/A1 Ratio test provides additional information about the quality and composition of lipoproteins in the blood. This ratio offers a more accurate assessment of cardiovascular risk beyond what is provided by total cholesterol, LDL cholesterol, and HDL cholesterol measurements alone.

Usually, overnight fasting is preferred for this test. Do not eat or drink anything except water before the test. It is important to inform your doctor about any heart medications or supplements you are taking, as some could impact the test results. Always seek your doctor’s advice before altering any medication routine.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results. The results of this test can guide your doctor to suggest lifestyle changes, medication management, and other interventions to reduce the risk of heart disease and improve heart health.

What is Apolipoprotein B/A1 Ratio used for?

An Apolipoprotein B/A1 Ratio test is done:

To identify individuals at risk for developing cardiovascular problems.
In individuals with risk factors like family history, obesity, diabetes, high blood pressure, and prior heart attack or stroke.
When an individual experiences symptoms suggestive of heart disease or cardiovascular problems such as chest pain, shortness of breath, palpitations, etc.
To help doctors formulate treatment plans according to individual patient needs.
To monitor the effectiveness of ongoing treatment in individuals already diagnosed with heart disease or to monitor the effect of lifestyle modifications in those identified as “high-risk” individuals for developing future heart-related ailments.

What does Apolipoprotein B/A1 Ratio measure?

An Apolipoprotein B/A1 Ratio test helps predict the risk of cardiovascular disease (CVD) in individuals at high risk, such as those who are obese, have a family history of heart disease, have high cholesterol, or have had similar health issues in the past. Apolipoprotein A1 is the primary protein associated with HDL cholesterol (good cholesterol), and its increased concentrations are associated with a reduced risk of cardiovascular disease. Apolipoprotein B is the primary protein associated with LDL cholesterol (bad cholesterol) and other lipid molecules. An increase in LDL cholesterol is associated with increased risk of cardiovascular disease. Therefore, an Apolipoprotein B/A1 Ratio test is a key marker of developing potential cardiovascular disease (CVD) or heart-related ailments.

References

Devaraj S, Semaan JR, Jialal I. Biochemistry, Apolipoprotein B. [Updated 2023 May 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538139/

Behbodikhah J, Ahmed S, Elyasi A, Kasselman LJ, De Leon J, Glass AD, Reiss AB. Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target. Metabolites. 2021 Oct 8;11(10):690. [Accessed 23 Apr. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8540246/#:~:text=A%20more%20recent%20discordance%20analysis,or%20non%2DHDL%2DC.

Apolipoprotein B-100 [Internet]. Healthdirect; [Accessed 23 Apr. 2024]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=apolipoprotein_b100

Thiriet M. Cardiovascular Risk Factors and Markers. Vasculopathies. 2019 Feb 19;8:91–198. [Accessed 23 Apr. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123062/#:~:text=The%20major%20independent%20cardiovascular%20risk,HDLCS%20concentration%20%5B226%5D

Cardiovascular Risk Factors and Markers. A literature review. Vasculopathies. 19 Jan. 2003. [Accessed 23 Apr. 2024]. Available from: https://link.springer.com/chapter/10.1007/978-3-319-89315-0_2

Ahmad M, Sniderman AD, Hegele RA. Apolipoprotein B in cardiovascular risk assessment. CMAJ. 2023 Aug 28;195(33):E1124. [Accessed 23 Apr. 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462411/#:~:text=Apolipoprotein%20B%20accurately%20predicts%20cardiovascular%20risk&text=Clinical%20trials%20of%20statins%2C%20ezetimibe,or%20non%2DHDL%2DC.